Reactive extraction technologies for organic acids in industrial fermentation processes : a review
- Author
- Sinah Tönjes (UGent) , Evelien Uitterhaegen, Karel De Winter and Wim Soetaert (UGent)
- Organization
- Abstract
- Reactive liquid-liquid extraction is an attractive, innovative technique to intensify the fermentative production and downstream processing of biobased organic acids through a selective partitioning to an organic phase. In an in situ product recovery (ISPR) approach, fermentation performance can be enhanced by alleviating product inhibition, yielding a relatively concentrated product stream. While reactive extraction has been widely studied for different organic acids in dilute aqueous solutions, its application to complex product streams from fermentation brings important added challenges. This review addresses these challenges and offers perspectives for future research and scale-up studies towards industrialisation. The complex interplay of solvent systems, extraction behaviour of different organic acids, and fermentation-dependent parameters is critically reviewed. Additionally, challenges faced upon implementation in industrial set-ups are discussed with a specific focus on ISPR technologies, discussing back extraction and resource recycling, as well as techno-economic considerations. To that end, potential process strategies and future research directions are proposed to overcome remaining limitations to bring this technology to an industrial level.
- Keywords
- Reactive extraction, Fermentation, Organic acids, In situ product recovery, Scale-up, SITU PRODUCT RECOVERY, TRI-N-OCTYLAMINE, L-PHENYLALANINE SEPARATION, LIQUID-LIQUID-EXTRACTION, FED-BATCH PROCESS, LACTIC-ACID, CARBOXYLIC-ACIDS, IN-SITU, 3-HYDROXYPROPIONIC ACID, AQUEOUS-SOLUTIONS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J9DXRJXVCQB6A07424686GP3
- MLA
- Tönjes, Sinah, et al. “Reactive Extraction Technologies for Organic Acids in Industrial Fermentation Processes : A Review.” SEPARATION AND PURIFICATION TECHNOLOGY, vol. 356, 2025, doi:10.1016/j.seppur.2024.129881.
- APA
- Tönjes, S., Uitterhaegen, E., De Winter, K., & Soetaert, W. (2025). Reactive extraction technologies for organic acids in industrial fermentation processes : a review. SEPARATION AND PURIFICATION TECHNOLOGY, 356. https://doi.org/10.1016/j.seppur.2024.129881
- Chicago author-date
- Tönjes, Sinah, Evelien Uitterhaegen, Karel De Winter, and Wim Soetaert. 2025. “Reactive Extraction Technologies for Organic Acids in Industrial Fermentation Processes : A Review.” SEPARATION AND PURIFICATION TECHNOLOGY 356. https://doi.org/10.1016/j.seppur.2024.129881.
- Chicago author-date (all authors)
- Tönjes, Sinah, Evelien Uitterhaegen, Karel De Winter, and Wim Soetaert. 2025. “Reactive Extraction Technologies for Organic Acids in Industrial Fermentation Processes : A Review.” SEPARATION AND PURIFICATION TECHNOLOGY 356. doi:10.1016/j.seppur.2024.129881.
- Vancouver
- 1.Tönjes S, Uitterhaegen E, De Winter K, Soetaert W. Reactive extraction technologies for organic acids in industrial fermentation processes : a review. SEPARATION AND PURIFICATION TECHNOLOGY. 2025;356.
- IEEE
- [1]S. Tönjes, E. Uitterhaegen, K. De Winter, and W. Soetaert, “Reactive extraction technologies for organic acids in industrial fermentation processes : a review,” SEPARATION AND PURIFICATION TECHNOLOGY, vol. 356, 2025.
@article{01J9DXRJXVCQB6A07424686GP3,
abstract = {{Reactive liquid-liquid extraction is an attractive, innovative technique to intensify the fermentative production and downstream processing of biobased organic acids through a selective partitioning to an organic phase. In an in situ product recovery (ISPR) approach, fermentation performance can be enhanced by alleviating product inhibition, yielding a relatively concentrated product stream. While reactive extraction has been widely studied for different organic acids in dilute aqueous solutions, its application to complex product streams from fermentation brings important added challenges. This review addresses these challenges and offers perspectives for future research and scale-up studies towards industrialisation. The complex interplay of solvent systems, extraction behaviour of different organic acids, and fermentation-dependent parameters is critically reviewed. Additionally, challenges faced upon implementation in industrial set-ups are discussed with a specific focus on ISPR technologies, discussing back extraction and resource recycling, as well as techno-economic considerations. To that end, potential process strategies and future research directions are proposed to overcome remaining limitations to bring this technology to an industrial level.}},
articleno = {{129881}},
author = {{Tönjes, Sinah and Uitterhaegen, Evelien and De Winter, Karel and Soetaert, Wim}},
issn = {{1383-5866}},
journal = {{SEPARATION AND PURIFICATION TECHNOLOGY}},
keywords = {{Reactive extraction,Fermentation,Organic acids,In situ product recovery,Scale-up,SITU PRODUCT RECOVERY,TRI-N-OCTYLAMINE,L-PHENYLALANINE SEPARATION,LIQUID-LIQUID-EXTRACTION,FED-BATCH PROCESS,LACTIC-ACID,CARBOXYLIC-ACIDS,IN-SITU,3-HYDROXYPROPIONIC ACID,AQUEOUS-SOLUTIONS}},
language = {{eng}},
pages = {{16}},
title = {{Reactive extraction technologies for organic acids in industrial fermentation processes : a review}},
url = {{http://doi.org/10.1016/j.seppur.2024.129881}},
volume = {{356}},
year = {{2025}},
}
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