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Supramolecular dye nanoassemblies for advanced diagnostics and therapies

Pouria Ramezani (UGent) , Stefaan De Smedt (UGent) and Félix Sauvage (UGent)
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Abstract
Dyes have conventionally been used in medicine for staining cells, tissues, and organelles. Since these compounds are also known as photosensitizers (PSs) which exhibit photoresponsivity upon photon illumination, there is a high desire towards formulating these molecules into nanoparticles (NPs) to achieve improved delivery efficiency and enhanced stability for novel imaging and therapeutic applications. Furthermore, it has been shown that some of the photophysical properties of these molecules can be altered upon NP formation thereby playing a major role in the outcome of their application. In this review, we primarily focus on introducing dye categories, their formulation strategies and how these strategies affect their photophysical properties in the context of photothermal and non‐photothermal applications. More specifically, the most recent progress showing the potential of dye supramolecular assemblies in modalities such as photoacoustic and fluorescence imaging, photothermal and photodynamic therapies as well as their employment in photoablation as a novel modality will be outlined. Aside from their photophysical activity, we delve shortly into the emerging application of dyes as drug stabilizing agents where these molecules are used together with aggregator molecules to form stable nanoparticles.
Keywords
dyes, fluorescence imaging, nanoparticles, photoacoustic imaging, photodynamic therapy, photothermal therapy, photoablation, stabilizers, AGGREGATION-INDUCED EMISSION, IN-VIVO FLUORESCENCE, NEAR-INFRARED WINDOW, INDOCYANINE GREEN, PHOTODYNAMIC THERAPY, GOLD NANOPARTICLES, SQUARAINE DYE, CYANINE DYE, IRON-OXIDE, ABSORPTION

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MLA
Ramezani, Pouria, et al. “Supramolecular Dye Nanoassemblies for Advanced Diagnostics and Therapies.” BIOENGINEERING & TRANSLATIONAL MEDICINE, vol. 9, no. 4, 2024, doi:10.1002/btm2.10652.
APA
Ramezani, P., De Smedt, S., & Sauvage, F. (2024). Supramolecular dye nanoassemblies for advanced diagnostics and therapies. BIOENGINEERING & TRANSLATIONAL MEDICINE, 9(4). https://doi.org/10.1002/btm2.10652
Chicago author-date
Ramezani, Pouria, Stefaan De Smedt, and Félix Sauvage. 2024. “Supramolecular Dye Nanoassemblies for Advanced Diagnostics and Therapies.” BIOENGINEERING & TRANSLATIONAL MEDICINE 9 (4). https://doi.org/10.1002/btm2.10652.
Chicago author-date (all authors)
Ramezani, Pouria, Stefaan De Smedt, and Félix Sauvage. 2024. “Supramolecular Dye Nanoassemblies for Advanced Diagnostics and Therapies.” BIOENGINEERING & TRANSLATIONAL MEDICINE 9 (4). doi:10.1002/btm2.10652.
Vancouver
1.
Ramezani P, De Smedt S, Sauvage F. Supramolecular dye nanoassemblies for advanced diagnostics and therapies. BIOENGINEERING & TRANSLATIONAL MEDICINE. 2024;9(4).
IEEE
[1]
P. Ramezani, S. De Smedt, and F. Sauvage, “Supramolecular dye nanoassemblies for advanced diagnostics and therapies,” BIOENGINEERING & TRANSLATIONAL MEDICINE, vol. 9, no. 4, 2024.
@article{01J8TN273H58EA47KXBXYD9FRC,
  abstract     = {{Dyes have conventionally been used in medicine for staining cells, tissues, and organelles. Since these compounds are also known as photosensitizers (PSs) which exhibit photoresponsivity upon photon illumination, there is a high desire towards formulating these molecules into nanoparticles (NPs) to achieve improved delivery efficiency and enhanced stability for novel imaging and therapeutic applications. Furthermore, it has been shown that some of the photophysical properties of these molecules can be altered upon NP formation thereby playing a major role in the outcome of their application. In this review, we primarily focus on introducing dye categories, their formulation strategies and how these strategies affect their photophysical properties in the context of photothermal and non‐photothermal applications. More specifically, the most recent progress showing the potential of dye supramolecular assemblies in modalities such as photoacoustic and fluorescence imaging, photothermal and photodynamic therapies as well as their employment in photoablation as a novel modality will be outlined. Aside from their photophysical activity, we delve shortly into the emerging application of dyes as drug stabilizing agents where these molecules are used together with aggregator molecules to form stable nanoparticles.}},
  articleno    = {{e10652}},
  author       = {{Ramezani, Pouria and De Smedt, Stefaan and Sauvage, Félix}},
  issn         = {{2380-6761}},
  journal      = {{BIOENGINEERING & TRANSLATIONAL MEDICINE}},
  keywords     = {{dyes,fluorescence imaging,nanoparticles,photoacoustic imaging,photodynamic therapy,photothermal therapy,photoablation,stabilizers,AGGREGATION-INDUCED EMISSION,IN-VIVO FLUORESCENCE,NEAR-INFRARED WINDOW,INDOCYANINE GREEN,PHOTODYNAMIC THERAPY,GOLD NANOPARTICLES,SQUARAINE DYE,CYANINE DYE,IRON-OXIDE,ABSORPTION}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{25}},
  title        = {{Supramolecular dye nanoassemblies for advanced diagnostics and therapies}},
  url          = {{http://doi.org/10.1002/btm2.10652}},
  volume       = {{9}},
  year         = {{2024}},
}

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