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Platinum deposition in the central nervous system : a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice

Angélica S. Reis, Jaini J. Paltian, William B. Domingues, Diogo L. R. Novo, Eduardo Bolea Fernandez (UGent) , Thibaut Van Acker (UGent) , Vinicius F. Campos, Cristiane Luchese, Frank Vanhaecke (UGent) , Marcia F. Mesko, et al.
(2025) MOLECULAR NEUROBIOLOGY. 62(3). p.3712-3729
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Abstract
Numerous factors can contribute to the incidence or exacerbation of peripheral neuropathy induced by oxaliplatin (OXA). Recently, platinum accumulation in the spinal cord of mice after OXA exposure, despite the efficient defenses of the central nervous system, has been demonstrated by our research group, expanding the knowledge about its toxicity. One hypothesis is platinum accumulation in the spinal cord causes oxidative damage to neurons and impairs mitochondrial function. Thus, the main aim of this study was to investigate the relationship between aging and OXA-induced neuropathic pain and its comorbidities, including anxious behavior and cognitive impairment. By using an OXA-induced peripheral neuropathy model, platinum and bioelement concentrations and their influence on oxidative damage, neuroprotection, and neuroplasticity pathways were evaluated in Swiss mice, and our findings showed that treatment with OXA exacerbated pain and anxious behavior, albeit not age-induced cognitive impairment. Platinum deposition in the spinal cord and, for the first time, in the brain of mice exposed to OXA, regardless of age, was identified. We found that alterations in bioelement concentration, oxidative damage, neuroprotection, and neuroplasticity pathways induced by aging contribute to OXA-induced peripheral neuropathy. Our results strive to supply a basis for therapeutic interventions for OXA-induced peripheral neuropathy considering age specificities.
Keywords
Neuropathy, Aging, Oxaliplatin, Platinum, Bioelements, Nrf2, OXIDATIVE STRESS, CHOLINERGIC NEUROTRANSMISSION, PAIN, PREVENTS, STRENGTH, PROTECTS, CALCIUM, BRAIN, MODEL, MASS

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MLA
Reis, Angélica S., et al. “Platinum Deposition in the Central Nervous System : A Novel Insight into Oxaliplatin-Induced Peripheral Neuropathy in Young and Old Mice.” MOLECULAR NEUROBIOLOGY, vol. 62, no. 3, 2025, pp. 3712–29, doi:10.1007/s12035-024-04430-y.
APA
Reis, A. S., Paltian, J. J., Domingues, W. B., Novo, D. L. R., Bolea Fernandez, E., Van Acker, T., … Wilhelm, E. A. (2025). Platinum deposition in the central nervous system : a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice. MOLECULAR NEUROBIOLOGY, 62(3), 3712–3729. https://doi.org/10.1007/s12035-024-04430-y
Chicago author-date
Reis, Angélica S., Jaini J. Paltian, William B. Domingues, Diogo L. R. Novo, Eduardo Bolea Fernandez, Thibaut Van Acker, Vinicius F. Campos, et al. 2025. “Platinum Deposition in the Central Nervous System : A Novel Insight into Oxaliplatin-Induced Peripheral Neuropathy in Young and Old Mice.” MOLECULAR NEUROBIOLOGY 62 (3): 3712–29. https://doi.org/10.1007/s12035-024-04430-y.
Chicago author-date (all authors)
Reis, Angélica S., Jaini J. Paltian, William B. Domingues, Diogo L. R. Novo, Eduardo Bolea Fernandez, Thibaut Van Acker, Vinicius F. Campos, Cristiane Luchese, Frank Vanhaecke, Marcia F. Mesko, and Ethel A. Wilhelm. 2025. “Platinum Deposition in the Central Nervous System : A Novel Insight into Oxaliplatin-Induced Peripheral Neuropathy in Young and Old Mice.” MOLECULAR NEUROBIOLOGY 62 (3): 3712–3729. doi:10.1007/s12035-024-04430-y.
Vancouver
1.
Reis AS, Paltian JJ, Domingues WB, Novo DLR, Bolea Fernandez E, Van Acker T, et al. Platinum deposition in the central nervous system : a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice. MOLECULAR NEUROBIOLOGY. 2025;62(3):3712–29.
IEEE
[1]
A. S. Reis et al., “Platinum deposition in the central nervous system : a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice,” MOLECULAR NEUROBIOLOGY, vol. 62, no. 3, pp. 3712–3729, 2025.
@article{01J8SYHZ4K6NTFAVGYZV51AEH4,
  abstract     = {{Numerous factors can contribute to the incidence or exacerbation of peripheral neuropathy induced by oxaliplatin (OXA). Recently, platinum accumulation in the spinal cord of mice after OXA exposure, despite the efficient defenses of the central nervous system, has been demonstrated by our research group, expanding the knowledge about its toxicity. One hypothesis is platinum accumulation in the spinal cord causes oxidative damage to neurons and impairs mitochondrial function. Thus, the main aim of this study was to investigate the relationship between aging and OXA-induced neuropathic pain and its comorbidities, including anxious behavior and cognitive impairment. By using an OXA-induced peripheral neuropathy model, platinum and bioelement concentrations and their influence on oxidative damage, neuroprotection, and neuroplasticity pathways were evaluated in Swiss mice, and our findings showed that treatment with OXA exacerbated pain and anxious behavior, albeit not age-induced cognitive impairment. Platinum deposition in the spinal cord and, for the first time, in the brain of mice exposed to OXA, regardless of age, was identified. We found that alterations in bioelement concentration, oxidative damage, neuroprotection, and neuroplasticity pathways induced by aging contribute to OXA-induced peripheral neuropathy. Our results strive to supply a basis for therapeutic interventions for OXA-induced peripheral neuropathy considering age specificities.}},
  author       = {{Reis, Angélica S. and Paltian, Jaini J. and Domingues, William B. and Novo, Diogo L. R. and Bolea Fernandez, Eduardo and Van Acker, Thibaut and Campos, Vinicius F. and Luchese, Cristiane and Vanhaecke, Frank and Mesko, Marcia F. and Wilhelm, Ethel A.}},
  issn         = {{0893-7648}},
  journal      = {{MOLECULAR NEUROBIOLOGY}},
  keywords     = {{Neuropathy,Aging,Oxaliplatin,Platinum,Bioelements,Nrf2,OXIDATIVE STRESS,CHOLINERGIC NEUROTRANSMISSION,PAIN,PREVENTS,STRENGTH,PROTECTS,CALCIUM,BRAIN,MODEL,MASS}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{3712--3729}},
  title        = {{Platinum deposition in the central nervous system : a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice}},
  url          = {{http://doi.org/10.1007/s12035-024-04430-y}},
  volume       = {{62}},
  year         = {{2025}},
}
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