- Author
- Tingting Ye (UGent)
- Promoter
- Bruno De Geest (UGent)
- Organization
- Abstract
- This thesis contributes to cancer immunotherapy by developing innovative cancer vaccine platforms using lipid nanoparticles (LNPs) and potent adjuvants to boost immunogenicity and efficacy. It begins with a review of vaccine technologies developed during the COVID-19 pandemic, focusing on LNPs for mRNA delivery and immune adjuvants. The research introduces ionizable biscarbamate lipids (IBLs), identifying S-Ac7-DOG as a top candidate for mRNA expression. A method for formulating peptide antigens and a TLR7/8 agonist into LNPs is presented, showing a strong CD8+ T cell response and protective tumor immunity. The study also finds that LNP formulations, particularly LNP(poly(I:C)), outperform soluble forms in stimulating immune responses. Additionally, a universal peptide encapsulation technology is developed, significantly enhancing CD8+ T cell responses when co-delivering peptides with TLR agonists. The work highlights its relevance to advancing personalized neoantigen vaccines, which offer tumor specificity and fewer off-target effects.
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J82GX9WR6CFTTQWRWS5F156Y
- MLA
- Ye, Tingting. Lipid Nanoparticle Formulation Strategies for Peptide-Based Cancer Vaccines. Ghent University. Faculty of Pharmaceutical Sciences, 2024.
- APA
- Ye, T. (2024). Lipid nanoparticle formulation strategies for peptide-based cancer vaccines. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
- Chicago author-date
- Ye, Tingting. 2024. “Lipid Nanoparticle Formulation Strategies for Peptide-Based Cancer Vaccines.” Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
- Chicago author-date (all authors)
- Ye, Tingting. 2024. “Lipid Nanoparticle Formulation Strategies for Peptide-Based Cancer Vaccines.” Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
- Vancouver
- 1.Ye T. Lipid nanoparticle formulation strategies for peptide-based cancer vaccines. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2024.
- IEEE
- [1]T. Ye, “Lipid nanoparticle formulation strategies for peptide-based cancer vaccines,” Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium, 2024.
@phdthesis{01J82GX9WR6CFTTQWRWS5F156Y,
abstract = {{This thesis contributes to cancer immunotherapy by developing innovative cancer vaccine platforms using lipid nanoparticles (LNPs) and potent adjuvants to boost immunogenicity and efficacy. It begins with a review of vaccine technologies developed during the COVID-19 pandemic, focusing on LNPs for mRNA delivery and immune adjuvants. The research introduces ionizable biscarbamate lipids (IBLs), identifying S-Ac7-DOG as a top candidate for mRNA expression. A method for formulating peptide antigens and a TLR7/8 agonist into LNPs is presented, showing a strong CD8+ T cell response and protective tumor immunity. The study also finds that LNP formulations, particularly LNP(poly(I:C)), outperform soluble forms in stimulating immune responses. Additionally, a universal peptide encapsulation technology is developed, significantly enhancing CD8+ T cell responses when co-delivering peptides with TLR agonists. The work highlights its relevance to advancing personalized neoantigen vaccines, which offer tumor specificity and fewer off-target effects.}},
author = {{Ye, Tingting}},
language = {{eng}},
pages = {{X, 208}},
publisher = {{Ghent University. Faculty of Pharmaceutical Sciences}},
school = {{Ghent University}},
title = {{Lipid nanoparticle formulation strategies for peptide-based cancer vaccines}},
year = {{2024}},
}