Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury.
- Author
- Christopher Anderson (UGent) , Laura Boeckaerts (UGent) , Priscilla Chin, Javier Burgoa (UGent) , Wei Xie (UGent) , Amanda Gonçalves (UGent) , Gillian Blancke (UGent) , Sam Benson, Sebastian Rogatti, Mariska S. Simpson, Anna Davey, Sze Men Choi (UGent) , Sandrien Desmet (UGent) , Summer D. Bushman, Geert Goeminne (UGent) , Peter Vandenabeele (UGent) , Mahesh S. Desai, Lars Vereecke (UGent) and Kodi Ravichandran (UGent)
- Organization
- Project
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- Death induced nutrient release fuels bacterial growth
- Clearance of dying cells and their relevance to health an disease
- MIMICRY - Modulating Immunity and the Microbiome for effective CRC Immunotherapy
- Microbes-4-Immunity: single-cell based sorting and investigation of the functional microbiome in intestinal and extra-intestinal immune homeostasis.
- Host-microbe interaction in intestinal homeostasis: unravelling the mechanisms involved in the onset of multiple inflammation-related diseases
- Studying the microbiota-immune-tumor axis in colorectal cancer using germfree and gnotobiotic mouse technology
- Cell death activity regulation in inflammation and cancer
- Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy
- Cell death modality regulation during immunotherapy (CREDIT): molecular mechanisms and experimental therapy.
- Improving cancer therapy by modulating cell death and the microbiome in the gut
- Abstract
- Cytotoxic chemotherapies have devastating side effects, particularly within the gastrointestinal tract. Gastrointestinal toxicity includes the death and damage of the epithelium and an imbalance in the intestinal microbiota, otherwise known as dysbiosis. Whether dysbiosis is a direct contributor to tissue toxicity is a key area of focus. Here, from both mammalian and bacterial perspectives, we uncover an intestinal epithelial cell death-Enterobacteriaceae signaling axis that fuels dysbiosis. Specifically, our data demonstrate that chemotherapy-induced epithelial cell apoptosis and the purine-containing metabolites released from dying cells drive the inter-kingdom transcriptional re-wiring of the Enterobacteriaceae, including fundamental shifts in bacterial respiration and promotion of purine utilization-dependent expansion, which in turn delays the recovery of the intestinal tract. Inhibition of epithelial cell death or restriction of the Enterobacteriaceae to homeostatic levels reverses dysbiosis and improves intestinal recovery. These findings suggest that supportive therapies that maintain homeostatic levels of Enterobacteriaceae may be useful in resolving intestinal disease.
- Keywords
- ESCHERICHIA-COLI K-12, GUT MICROBIOTA, GENE-EXPRESSION, PANETH CELLS, RESPIRATION, TOXICITY, DIARRHEA, GROWTH, RESISTANCE, DYSBIOSIS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J7GPXX48KQK5RTR5CP2MGTX4
- MLA
- Anderson, Christopher, et al. “Metabolite-Based Inter-Kingdom Communication Controls Intestinal Tissue Recovery Following Chemotherapeutic Injury.” CELL HOST & MICROBE, vol. 32, no. 9, 2024, pp. 1469–87, doi:10.1016/j.chom.2024.07.026.
- APA
- Anderson, C., Boeckaerts, L., Chin, P., Burgoa, J., Xie, W., Gonçalves, A., … Ravichandran, K. (2024). Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury. CELL HOST & MICROBE, 32(9), 1469–1487. https://doi.org/10.1016/j.chom.2024.07.026
- Chicago author-date
- Anderson, Christopher, Laura Boeckaerts, Priscilla Chin, Javier Burgoa, Wei Xie, Amanda Gonçalves, Gillian Blancke, et al. 2024. “Metabolite-Based Inter-Kingdom Communication Controls Intestinal Tissue Recovery Following Chemotherapeutic Injury.” CELL HOST & MICROBE 32 (9): 1469–87. https://doi.org/10.1016/j.chom.2024.07.026.
- Chicago author-date (all authors)
- Anderson, Christopher, Laura Boeckaerts, Priscilla Chin, Javier Burgoa, Wei Xie, Amanda Gonçalves, Gillian Blancke, Sam Benson, Sebastian Rogatti, Mariska S. Simpson, Anna Davey, Sze Men Choi, Sandrien Desmet, Summer D. Bushman, Geert Goeminne, Peter Vandenabeele, Mahesh S. Desai, Lars Vereecke, and Kodi Ravichandran. 2024. “Metabolite-Based Inter-Kingdom Communication Controls Intestinal Tissue Recovery Following Chemotherapeutic Injury.” CELL HOST & MICROBE 32 (9): 1469–1487. doi:10.1016/j.chom.2024.07.026.
- Vancouver
- 1.Anderson C, Boeckaerts L, Chin P, Burgoa J, Xie W, Gonçalves A, et al. Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury. CELL HOST & MICROBE. 2024;32(9):1469–87.
- IEEE
- [1]C. Anderson et al., “Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury.,” CELL HOST & MICROBE, vol. 32, no. 9, pp. 1469–1487, 2024.
@article{01J7GPXX48KQK5RTR5CP2MGTX4,
abstract = {{Cytotoxic chemotherapies have devastating side effects, particularly within the gastrointestinal tract. Gastrointestinal toxicity includes the death and damage of the epithelium and an imbalance in the intestinal microbiota, otherwise known as dysbiosis. Whether dysbiosis is a direct contributor to tissue toxicity is a key area of focus. Here, from both mammalian and bacterial perspectives, we uncover an intestinal epithelial cell death-Enterobacteriaceae signaling axis that fuels dysbiosis. Specifically, our data demonstrate that chemotherapy-induced epithelial cell apoptosis and the purine-containing metabolites released from dying cells drive the inter-kingdom transcriptional re-wiring of the Enterobacteriaceae, including fundamental shifts in bacterial respiration and promotion of purine utilization-dependent expansion, which in turn delays the recovery of the intestinal tract. Inhibition of epithelial cell death or restriction of the Enterobacteriaceae to homeostatic levels reverses dysbiosis and improves intestinal recovery. These findings suggest that supportive therapies that maintain homeostatic levels of Enterobacteriaceae may be useful in resolving intestinal disease.}},
author = {{Anderson, Christopher and Boeckaerts, Laura and Chin, Priscilla and Burgoa, Javier and Xie, Wei and Gonçalves, Amanda and Blancke, Gillian and Benson, Sam and Rogatti, Sebastian and Simpson, Mariska S. and Davey, Anna and Choi, Sze Men and Desmet, Sandrien and Bushman, Summer D. and Goeminne, Geert and Vandenabeele, Peter and Desai, Mahesh S. and Vereecke, Lars and Ravichandran, Kodi}},
issn = {{1931-3128}},
journal = {{CELL HOST & MICROBE}},
keywords = {{ESCHERICHIA-COLI K-12,GUT MICROBIOTA,GENE-EXPRESSION,PANETH CELLS,RESPIRATION,TOXICITY,DIARRHEA,GROWTH,RESISTANCE,DYSBIOSIS}},
language = {{eng}},
number = {{9}},
pages = {{1469--1487}},
title = {{Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury.}},
url = {{http://doi.org/10.1016/j.chom.2024.07.026}},
volume = {{32}},
year = {{2024}},
}
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