@article{01J7FXHZTQDH2YK79963SYXDSW,
  abstract     = {{Background: Although psychological factors have been implicated in patients with functional dysphonia (FD), conventional voice therapy (CVT) typically targets the aberrant voice symptoms exclusively. Yet, CVT is not always successful, and in view of the significant adverse quality of life impact combined with the financial burden on the healthcare system and society, research is needed to elucidate the underlying psychophysiology of FD and improve treatment outcomes.

Objectives: The first objective of this research project is to compare the occurrence and frequency of symptoms and/or disorders related to autonomic nervous system (ANS) dysfunction in patients with FD with gender- and age-matched vocally healthy controls, using a case-control study. The second objective is to compare the effects of a novel therapy for FD based on ANS regulation (i.e., ANS therapy: heart rate variability (HRV) biofeedback) on both autonomic function and voice function versus CVT alone or in combination with ANS therapy (i.e., ANS therapy + CVT), using a randomized controlled trial (RCT).

Methods: Case-control study: Autonomic (dys)function of patients with FD will be compared with gender- and age-matched vocally healthy controls, using both physiological measures (e.g., HRV, skin conductance level) and psychological patient-reported outcome measures (PROMs, e.g., Neuroception of Psychological Safety Scale, Depression Anxiety and Stress Scale). RCT: The FD group will be randomly assigned to the innovative ANS therapy group, the CVT group or the ANS therapy + CVT group. All patients received 1 month of treatment with 20 min of daily practice. Both the autonomic assessment and the voice assessment will be performed pretherapy and immediately after therapy by assessors blinded to group allocation and study phase.

Expected results: Higher occurrences of symptoms and/or disorders related to autonomic dysfunction are expected in patients with FD compared with vocally healthy controls. Physiological outcomes: lower HRV, lower cardiac pre-ejection period, higher respiration rate and higher skin conductance level are hypothesized in patients with FD compared with vocally healthy controls. Psychological PROMs: higher self-report of feelings/symptoms related to autonomic dysfunction (e.g., perceived stress, anxiety) is expected in patients with FD compared with vocally healthy controls. The autonomic function is hypothesized to improve more after the ANS therapy and the ANS therapy + CVT compared with the CVT only. Voice function is expected to improve more after the ANS therapy + CVT compared with the ANS therapy and the CVT alone.}},
  author       = {{Meerschman, Iris and D'haeseleer, Evelien and Vanderhasselt, Marie-Anne and Claeys, Sofie and Vonck, Kristl and Vergauwe, Riet and Van Nuffelen, Gwen and Desuter, Gauthier and Roy, Nelson and Van Lierde, Kristiane}},
  issn         = {{1368-2822}},
  journal      = {{INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS}},
  keywords     = {{neuropsychology,speech and language therapy,voice,voice disorder,HEART-RATE-VARIABILITY,RESPIRATORY SINUS ARRHYTHMIA,POSTTRAUMATIC-STRESS-DISORDER,MUSCLE TENSION DYSPHONIA,VOICE DISORDERS,SELF-REGULATION,NEUROVISCERAL INTEGRATION,PSYCHOMETRIC ANALYSIS,PSYCHOLOGICAL STRESS,SHORT-TERM}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2723--2736}},
  title        = {{Exploring autonomic dysfunction in functional dysphonia : a protocol for a case-control study and a randomized controlled trial}},
  url          = {{http://doi.org/10.1111/1460-6984.13111}},
  volume       = {{59}},
  year         = {{2024}},
}

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