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Abstract
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B*15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Keywords
HEPATITIS-C, EFFICIENT

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MLA
Marchal, Astrid, et al. “Lack of Association between Classical HLA Genes and Asymptomatic SARS-CoV-2 Infection.” HUMAN GENETICS AND GENOMICS ADVANCES, vol. 5, no. 3, 2024, doi:10.1016/j.xhgg.2024.100300.
APA
Marchal, A., Cirulli, E. T., Neveux, I., Bellos, E., Thwaites, R. S., Barrett, K. M. S., … COVID Study Grp, [missing]. (2024). Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection. HUMAN GENETICS AND GENOMICS ADVANCES, 5(3). https://doi.org/10.1016/j.xhgg.2024.100300
Chicago author-date
Marchal, Astrid, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, et al. 2024. “Lack of Association between Classical HLA Genes and Asymptomatic SARS-CoV-2 Infection.” HUMAN GENETICS AND GENOMICS ADVANCES 5 (3). https://doi.org/10.1016/j.xhgg.2024.100300.
Chicago author-date (all authors)
Marchal, Astrid, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, Andras N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L. Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J. Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurelie Cobat, Alexandre Bolze, Filomeen Haerynck, Simon Tavernier, Jens Van Praet, Bart Lambrecht, Eva Van Braeckel, Cedric Bosteels, Levi Hoste, Eric Hoste, Fre Bauters, Jozefien Declercq, Leslie Naesens, [missing] COVIDeF Study Grp, [missing] French COVID Cohort Study Grp, [missing] CoV-Contact Cohort, [missing] COVID-STORM Clinicians, [missing] COVID Clinicians, [missing] Orchestra Working Grp, [missing] Amsterdam UMC COVID-19 Biobank, [missing] AID-USUHSCOVID Study Grp, and [missing] COVID Study Grp. 2024. “Lack of Association between Classical HLA Genes and Asymptomatic SARS-CoV-2 Infection.” HUMAN GENETICS AND GENOMICS ADVANCES 5 (3). doi:10.1016/j.xhgg.2024.100300.
Vancouver
1.
Marchal A, Cirulli ET, Neveux I, Bellos E, Thwaites RS, Barrett KMS, et al. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection. HUMAN GENETICS AND GENOMICS ADVANCES. 2024;5(3).
IEEE
[1]
A. Marchal et al., “Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection,” HUMAN GENETICS AND GENOMICS ADVANCES, vol. 5, no. 3, 2024.
@article{01J55NN49PD0XP8899TJQQXYFH,
  abstract     = {{Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B*15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.}},
  articleno    = {{100300}},
  author       = {{Marchal, Astrid and  Cirulli, Elizabeth T. and  Neveux, Iva and  Bellos, Evangelos and  Thwaites, Ryan S. and  Barrett, Kelly M. Schiabor and  Zhang, Yu and  Nemes-Bokun, Ivana and  Kalinova, Mariya and  Catchpole, Andrew and  Tangye, Stuart G. and  Spaan, Andras N. and  Lack, Justin B. and  Ghosn, Jade and  Burdet, Charles and  Gorochov, Guy and  Tubach, Florence and  Hausfater, Pierre and  Dalgard, Clifton L. and  Zhang, Shen-Ying and  Zhang, Qian and  Chiu, Christopher and  Fellay, Jacques and  Grzymski, Joseph J. and  Sancho-Shimizu, Vanessa and  Abel, Laurent and  Casanova, Jean-Laurent and  Cobat, Aurelie and Bolze, Alexandre and Haerynck, Filomeen and Tavernier, Simon and Van Praet, Jens and Lambrecht, Bart and Van Braeckel, Eva and Bosteels, Cedric and Hoste, Levi and Hoste, Eric and Bauters, Fre and Declercq, Jozefien and Naesens, Leslie and COVIDeF Study Grp, [missing] and French COVID Cohort Study Grp, [missing] and CoV-Contact Cohort, [missing] and COVID-STORM Clinicians, [missing] and COVID Clinicians, [missing] and Orchestra Working Grp, [missing] and Amsterdam UMC COVID-19 Biobank, [missing] and AID-USUHSCOVID Study Grp, [missing] and COVID Study Grp, [missing]}},
  issn         = {{2666-2477}},
  journal      = {{HUMAN GENETICS AND GENOMICS ADVANCES}},
  keywords     = {{HEPATITIS-C,EFFICIENT}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{12}},
  title        = {{Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection}},
  url          = {{http://doi.org/10.1016/j.xhgg.2024.100300}},
  volume       = {{5}},
  year         = {{2024}},
}

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