Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches
- Author
- Niels Hilhorst (UGent) , Barbara Devocht (UGent) , Evelien Verhaeghe (UGent) , Lore Lapeire (UGent) , Linos Vandekerckhove (UGent) , Soetkin Desmet, Marie-Angélique De Scheerder (UGent) and Lieve Brochez (UGent)
- Organization
- Abstract
- Kaposi sarcoma (KS) is a tumor originating from endothelial cells, both vascular and lymphatic, and is associated with human herpesvirus 8 (HHV-8). Four distinct KS subtypes have been defined: Classic, endemic, iatrogenic, and epidemic or acquired immunodeficiency syndrome (AIDS)-related KS. A fifth subtype has more recently been recognized in men who have sex with men (MSM) in the absence HIV infection. We report here on three cases of KS in HIV-negative MSM and review the literature. Two patients were treated with topical propranolol, resulting in a partial response in one and no response in the other. The third patient was treated with pegylated liposomal doxorubicin (PLD), which led to regression/flattening of multiple lesions as well as symptom relief. To the best of our knowledge, this is the first case series that reports on the use of topical propranolol and PLD in this KS subtype. Further research into this fifth subtype of KS is warranted as the optimal management strategy remains unclear.
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J4M0BTZ1ZSAFCDVR3R8TPJPS
- MLA
- Hilhorst, Niels, et al. “Case Series of Kaposi Sarcoma in HIV-Negative Men Who Have Sex with Men : Potential Therapeutic Approaches.” JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY, vol. 10, no. 1, 2024, pp. 1–6, doi:10.23937/2469-5750/1510127.
- APA
- Hilhorst, N., Devocht, B., Verhaeghe, E., Lapeire, L., Vandekerckhove, L., Desmet, S., … Brochez, L. (2024). Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches. JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY, 10(1), 1–6. https://doi.org/10.23937/2469-5750/1510127
- Chicago author-date
- Hilhorst, Niels, Barbara Devocht, Evelien Verhaeghe, Lore Lapeire, Linos Vandekerckhove, Soetkin Desmet, Marie-Angélique De Scheerder, and Lieve Brochez. 2024. “Case Series of Kaposi Sarcoma in HIV-Negative Men Who Have Sex with Men : Potential Therapeutic Approaches.” JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY 10 (1): 1–6. https://doi.org/10.23937/2469-5750/1510127.
- Chicago author-date (all authors)
- Hilhorst, Niels, Barbara Devocht, Evelien Verhaeghe, Lore Lapeire, Linos Vandekerckhove, Soetkin Desmet, Marie-Angélique De Scheerder, and Lieve Brochez. 2024. “Case Series of Kaposi Sarcoma in HIV-Negative Men Who Have Sex with Men : Potential Therapeutic Approaches.” JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY 10 (1): 1–6. doi:10.23937/2469-5750/1510127.
- Vancouver
- 1.Hilhorst N, Devocht B, Verhaeghe E, Lapeire L, Vandekerckhove L, Desmet S, et al. Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches. JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY. 2024;10(1):1–6.
- IEEE
- [1]N. Hilhorst et al., “Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches,” JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY, vol. 10, no. 1, pp. 1–6, 2024.
@article{01J4M0BTZ1ZSAFCDVR3R8TPJPS,
abstract = {{Kaposi sarcoma (KS) is a tumor originating from endothelial cells, both vascular and lymphatic, and is associated with human herpesvirus 8 (HHV-8). Four distinct KS subtypes have been defined: Classic, endemic, iatrogenic, and epidemic or acquired immunodeficiency syndrome (AIDS)-related KS. A fifth subtype has more recently been recognized in men who have sex with men (MSM) in the absence HIV infection. We report here on three cases of KS in HIV-negative MSM and review the literature. Two patients were treated with topical propranolol, resulting in a partial response in one and no response in the other. The third patient was treated with pegylated liposomal doxorubicin (PLD), which led to regression/flattening of multiple lesions as well as symptom relief. To the best of our knowledge, this is the first case series that reports on the use of topical propranolol and PLD in this KS subtype. Further research into this fifth subtype of KS is warranted as the optimal management strategy remains unclear.}},
articleno = {{127}},
author = {{Hilhorst, Niels and Devocht, Barbara and Verhaeghe, Evelien and Lapeire, Lore and Vandekerckhove, Linos and Desmet, Soetkin and De Scheerder, Marie-Angélique and Brochez, Lieve}},
issn = {{2469-5750}},
journal = {{JOURNAL OF DERMATOLOGY RESEARCH AND THERAPY}},
language = {{eng}},
number = {{1}},
pages = {{127:1--127:6}},
title = {{Case series of kaposi sarcoma in HIV-negative men who have sex with men : potential therapeutic approaches}},
url = {{http://doi.org/10.23937/2469-5750/1510127}},
volume = {{10}},
year = {{2024}},
}
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