Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
- Author
- Joline Ingels (UGent) , Laurenz De Cock (UGent) , Dieter Stevens (UGent) , Rupert Mayer (UGent) , Fabien Henri Thery (UGent) , Guillem Sanchez Sanchez, David Vermijlen, Karin Weening (UGent) , Saskia De Smet (UGent) , Nele Lootens (UGent) , Marieke Brusseel (UGent) , Tasja Verstraete (UGent) , Jolien Buyle (UGent) , Eva Van Houtte (UGent) , Pam Devreker, Kelly Heyns (UGent) , Stijn De Munter (UGent) , Sandra Van Lint (UGent) , Glenn Goetgeluk (UGent) , Sarah Bonte, Lore Billiet (UGent) , Melissa Pille (UGent) , Hanne Jansen, Eva Pascal (UGent) , Lucas Deseins (UGent) , Lies Vantomme (UGent) , Maarten Verdonckt, Ria Roelandt (UGent) , Thomas Eekhout (UGent) , Niels Vandamme (UGent) , Georges Leclercq (UGent) , Tom Taghon (UGent) , Tessa Kerre (UGent) , Floris Vanommeslaeghe, Annemieke Dhondt (UGent) , Liesbeth Ferdinande (UGent) , Jo Van Dorpe (UGent) , Liesbeth Desender (UGent) , Frederic De Ryck (UGent) , Frank Vermassen (UGent) , Veerle Surmont (UGent) , Francis Impens (UGent) , Björn Menten (UGent) , Karim Vermaelen (UGent) and Bart Vandekerckhove (UGent)
- Organization
- Project
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- Patient-friendly tumor sampling for the design, and reduction of the production time of a neoepitope dendritic cell vaccine for patients presenting with inoperable non small cell lung carcinoma (NEO4LUNG)
- Proteomics-derived epitopes for dramatically improved anticancer and antibacterial vaccine development
- Improving Neo-epitope Identification in lung cancer patients using Mass spectrometry and next generation sequencing (INI-M&N)
- Proteomics-based characterization of the protein interplay between pathogenic bacteria and their host.
- Immunomonitoring of patients with non-small cell lung carcinoma treated with a tumor mutanome-targeted dendritic cell vaccine
- In-depth comparison and feasibility assessment of an integrated pipeline for neoantigen identification and HLA ligandome sequencing in a clinical setting
- Characterization of a novel innate CD8 PD1 positive thymic T cell population and its progeny in cord blood
- Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumors
- Development and functional validation of a gene editing approach in hematopoietic precursor cells for Wiskott-Aldrich Syndrome
- Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumors
- Optimisation of CD70-targeted adoptive cell therapy
- 3L000209
- Abstract
- Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell (DC) vaccine targeting patient-individual neoantigens is evaluated in patients with resected NSCLC. Vaccine manufacturing is feasible in six of 10 enrolled patients. Toxicity is limited to grade 1–2 adverse events. Systemic T cell responses are observed in five out of six vaccinated patients, with T cell responses remaining detectable up to 19 months post vaccination. Single-cell analysis indicates that the responsive T cell population is polyclonal and exhibits the near-entire spectrum of T cell differentiation states, including a naive-like state, but excluding exhausted cell states. Three of six vaccinated patients experience disease recurrence during the follow-up period of 2 years. Collectively, these data support the feasibility, safety, and immunogenicity of this treatment in resected NSCLC.
- Keywords
- CD8 T-CELLS, LUNG-CANCER, PD-1 BLOCKADE, MEMORY, MUTATIONS, DIVERSITY, MELANOMA, ENABLES, HEALTH, IDENTIFICATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J4K7A99BTHNT3Y3QMPW6SM81
- MLA
- Ingels, Joline, et al. “Neoantigen-Targeted Dendritic Cell Vaccination in Lung Cancer Patients Induces Long-Lived T Cells Exhibiting the Full Differentiation Spectrum.” CELL REPORTS MEDICINE, vol. 5, no. 5, 2024, doi:10.1016/j.xcrm.2024.101516.
- APA
- Ingels, J., De Cock, L., Stevens, D., Mayer, R., Thery, F. H., Sanchez, G. S., … Vandekerckhove, B. (2024). Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum. CELL REPORTS MEDICINE, 5(5). https://doi.org/10.1016/j.xcrm.2024.101516
- Chicago author-date
- Ingels, Joline, Laurenz De Cock, Dieter Stevens, Rupert Mayer, Fabien Henri Thery, Guillem Sanchez Sanchez, David Vermijlen, et al. 2024. “Neoantigen-Targeted Dendritic Cell Vaccination in Lung Cancer Patients Induces Long-Lived T Cells Exhibiting the Full Differentiation Spectrum.” CELL REPORTS MEDICINE 5 (5). https://doi.org/10.1016/j.xcrm.2024.101516.
- Chicago author-date (all authors)
- Ingels, Joline, Laurenz De Cock, Dieter Stevens, Rupert Mayer, Fabien Henri Thery, Guillem Sanchez Sanchez, David Vermijlen, Karin Weening, Saskia De Smet, Nele Lootens, Marieke Brusseel, Tasja Verstraete, Jolien Buyle, Eva Van Houtte, Pam Devreker, Kelly Heyns, Stijn De Munter, Sandra Van Lint, Glenn Goetgeluk, Sarah Bonte, Lore Billiet, Melissa Pille, Hanne Jansen, Eva Pascal, Lucas Deseins, Lies Vantomme, Maarten Verdonckt, Ria Roelandt, Thomas Eekhout, Niels Vandamme, Georges Leclercq, Tom Taghon, Tessa Kerre, Floris Vanommeslaeghe, Annemieke Dhondt, Liesbeth Ferdinande, Jo Van Dorpe, Liesbeth Desender, Frederic De Ryck, Frank Vermassen, Veerle Surmont, Francis Impens, Björn Menten, Karim Vermaelen, and Bart Vandekerckhove. 2024. “Neoantigen-Targeted Dendritic Cell Vaccination in Lung Cancer Patients Induces Long-Lived T Cells Exhibiting the Full Differentiation Spectrum.” CELL REPORTS MEDICINE 5 (5). doi:10.1016/j.xcrm.2024.101516.
- Vancouver
- 1.Ingels J, De Cock L, Stevens D, Mayer R, Thery FH, Sanchez GS, et al. Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum. CELL REPORTS MEDICINE. 2024;5(5).
- IEEE
- [1]J. Ingels et al., “Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum,” CELL REPORTS MEDICINE, vol. 5, no. 5, 2024.
@article{01J4K7A99BTHNT3Y3QMPW6SM81,
abstract = {{Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial in which a dendritic cell (DC) vaccine targeting patient-individual neoantigens is evaluated in patients with resected NSCLC. Vaccine manufacturing is feasible in six of 10 enrolled patients. Toxicity is limited to grade 1–2 adverse events. Systemic T cell responses are observed in five out of six vaccinated patients, with T cell responses remaining detectable up to 19 months post vaccination. Single-cell analysis indicates that the responsive T cell population is polyclonal and exhibits the near-entire spectrum of T cell differentiation states, including a naive-like state, but excluding exhausted cell states. Three of six vaccinated patients experience disease recurrence during the follow-up period of 2 years. Collectively, these data support the feasibility, safety, and immunogenicity of this treatment in resected NSCLC.}},
articleno = {{101516}},
author = {{Ingels, Joline and De Cock, Laurenz and Stevens, Dieter and Mayer, Rupert and Thery, Fabien Henri and Sanchez, Guillem Sanchez and Vermijlen, David and Weening, Karin and De Smet, Saskia and Lootens, Nele and Brusseel, Marieke and Verstraete, Tasja and Buyle, Jolien and Van Houtte, Eva and Devreker, Pam and Heyns, Kelly and De Munter, Stijn and Van Lint, Sandra and Goetgeluk, Glenn and Bonte, Sarah and Billiet, Lore and Pille, Melissa and Jansen, Hanne and Pascal, Eva and Deseins, Lucas and Vantomme, Lies and Verdonckt, Maarten and Roelandt, Ria and Eekhout, Thomas and Vandamme, Niels and Leclercq, Georges and Taghon, Tom and Kerre, Tessa and Vanommeslaeghe, Floris and Dhondt, Annemieke and Ferdinande, Liesbeth and Van Dorpe, Jo and Desender, Liesbeth and De Ryck, Frederic and Vermassen, Frank and Surmont, Veerle and Impens, Francis and Menten, Björn and Vermaelen, Karim and Vandekerckhove, Bart}},
issn = {{2666-3791}},
journal = {{CELL REPORTS MEDICINE}},
keywords = {{CD8 T-CELLS,LUNG-CANCER,PD-1 BLOCKADE,MEMORY,MUTATIONS,DIVERSITY,MELANOMA,ENABLES,HEALTH,IDENTIFICATION}},
language = {{eng}},
number = {{5}},
pages = {{31}},
title = {{Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum}},
url = {{http://doi.org/10.1016/j.xcrm.2024.101516}},
volume = {{5}},
year = {{2024}},
}
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