@article{01J41B71QEY6MNJWSZZSPVTJQR,
  abstract     = {{Approximately 60% of the genes and gene products in the model species Arabidopsis thaliana have been functionally characterized. In non-model plant species, the functional annotation of the gene space is largely based on homology, with the assumption that genes with shared common ancestry have conserved functions. However, the wide variety in possible morphological, physiological, and ecological differences between plant species gives rise to many species- and clade-specific genes, for which this transfer of knowledge is not possible. Other complications, such as difficulties with genetic transformation, the absence of large-scale mutagenesis methods, and long generation times, further lead to the slow characterization of genes in non-model species. Here, we discuss different resources that integrate plant gene function information. Different approaches that support the functional annotation of gene products, based on orthology or network biology, are described. While sequence-based tools to characterize the functional landscape in non-model species are maturing and becoming more readily available, easy-to-use network-based methods inferring plant gene functions are not as prevalent and have limited functionality.}},
  articleno    = {{e14441}},
  author       = {{Vandepoele, Klaas and Thierens, Sander and Van Bel, Michiel}},
  issn         = {{0031-9317}},
  journal      = {{PHYSIOLOGIA PLANTARUM}},
  keywords     = {{RESOURCE,COMPLETENESS,EVOLUTION,DATABASE,REVEALS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{9}},
  title        = {{Application of orthology and network biology to infer gene functions in non‐model plants}},
  url          = {{http://doi.org/10.1111/ppl.14441}},
  volume       = {{176}},
  year         = {{2024}},
}

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