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Human biomonitoring of multiple mycotoxins in sera of Flemish adult population : results of the FLEXiGUT project

Elias Maris (UGent) , Roger Peró Gascón (UGent) , Hadiza Lawal Abdullahi, Arnau Vich Vila, Muriel Derrien, Jeroen Raes, Marthe De Boevre (UGent) and Sarah De Saeger (UGent)
(2024) International Society of Toxinology, 22nd World Congress, Abstracts.
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Abstract
Throughout life, almost everyone is exposed to mycotoxins through varying, low-dose diets, and the risk of chronic multiple mycotoxin exposure is not well understood. It has been demonstrated that certain mycotoxins affect the gut microbiome and are associated with detrimental consequences on delicate intestinal structures as well as a reduction in intestinal integrity. The correlation between the gut microbiome-inflammatory axis and chronic diseases is bolstered by the recent identification of the cross-disease Bacteroides2 enterotype, which has been linked to both systemic and gut inflammatory markers such as serum C-reactive protein and faecal calprotectin. Multiple mycotoxin exposure was investigated in serum samples from the Flemish adult population (n=385), participating in the Flemish Gut Flora Project (FGFP) cohort; using an analytical method we have developed for the identification and quantification of 41 mycotoxins and metabolites in human biospecimens by LC-MS/MS. Fourteen different mycotoxins and their metabolites were detected. All subjects were exposed to ochratoxin A and 27.3% of participants were exposed to two or more mycotoxins. Future research aims to investigate associations between multi-mycotoxin exposure and dietary patterns, alterations of the gut microbiota, chronic low-grade gut inflammation, and related biological diseases.

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Citation

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MLA
Maris, Elias, et al. “Human Biomonitoring of Multiple Mycotoxins in Sera of Flemish Adult Population : Results of the FLEXiGUT Project.” International Society of Toxinology, 22nd World Congress, Abstracts, 2024.
APA
Maris, E., Peró Gascón, R., Abdullahi, H. L., Vich Vila, A., Derrien, M., Raes, J., … De Saeger, S. (2024). Human biomonitoring of multiple mycotoxins in sera of Flemish adult population : results of the FLEXiGUT project. International Society of Toxinology, 22nd World Congress, Abstracts. Presented at the 22nd International Society of Toxinology World Congress, Singapore.
Chicago author-date
Maris, Elias, Roger Peró Gascón, Hadiza Lawal Abdullahi, Arnau Vich Vila, Muriel Derrien, Jeroen Raes, Marthe De Boevre, and Sarah De Saeger. 2024. “Human Biomonitoring of Multiple Mycotoxins in Sera of Flemish Adult Population : Results of the FLEXiGUT Project.” In International Society of Toxinology, 22nd World Congress, Abstracts.
Chicago author-date (all authors)
Maris, Elias, Roger Peró Gascón, Hadiza Lawal Abdullahi, Arnau Vich Vila, Muriel Derrien, Jeroen Raes, Marthe De Boevre, and Sarah De Saeger. 2024. “Human Biomonitoring of Multiple Mycotoxins in Sera of Flemish Adult Population : Results of the FLEXiGUT Project.” In International Society of Toxinology, 22nd World Congress, Abstracts.
Vancouver
1.
Maris E, Peró Gascón R, Abdullahi HL, Vich Vila A, Derrien M, Raes J, et al. Human biomonitoring of multiple mycotoxins in sera of Flemish adult population : results of the FLEXiGUT project. In: International Society of Toxinology, 22nd World Congress, Abstracts. 2024.
IEEE
[1]
E. Maris et al., “Human biomonitoring of multiple mycotoxins in sera of Flemish adult population : results of the FLEXiGUT project,” in International Society of Toxinology, 22nd World Congress, Abstracts, Singapore, 2024.
@inproceedings{01J3Z71NNKV4SBMSEHN5RG5T3F,
  abstract     = {{Throughout life, almost everyone is exposed to mycotoxins through varying, low-dose diets, and the 
risk of chronic multiple mycotoxin exposure is not well understood. It has been demonstrated that 
certain mycotoxins affect the gut microbiome and are associated with detrimental consequences on 
delicate intestinal structures as well as a reduction in intestinal integrity. The correlation between the 
gut microbiome-inflammatory axis and chronic diseases is bolstered by the recent identification of the 
cross-disease Bacteroides2 enterotype, which has been linked to both systemic and gut inflammatory 
markers such as serum C-reactive protein and faecal calprotectin. Multiple mycotoxin exposure was 
investigated in serum samples from the Flemish adult population (n=385), participating in the Flemish 
Gut Flora Project (FGFP) cohort; using an analytical method we have developed for the identification 
and quantification of 41 mycotoxins and metabolites in human biospecimens by LC-MS/MS. Fourteen 
different mycotoxins and their metabolites were detected. All subjects were exposed to ochratoxin A
and 27.3% of participants were exposed to two or more mycotoxins. Future research aims to investigate 
associations between multi-mycotoxin exposure and dietary patterns, alterations of the gut microbiota, 
chronic low-grade gut inflammation, and related biological diseases.}},
  author       = {{Maris, Elias and Peró Gascón, Roger and Abdullahi, Hadiza Lawal and Vich Vila, Arnau and Derrien, Muriel and Raes, Jeroen and De Boevre, Marthe and De Saeger, Sarah}},
  booktitle    = {{International Society of Toxinology, 22nd World Congress, Abstracts}},
  language     = {{eng}},
  location     = {{Singapore}},
  pages        = {{1}},
  title        = {{Human biomonitoring of multiple mycotoxins in sera of Flemish adult population : results of the FLEXiGUT project}},
  year         = {{2024}},
}