Epigenetics in personalized toxicity
- Author
- Laura Corveleyn (UGent) , Sigrid Verhelst (UGent) , Dieter Deforce (UGent) and Maarten Dhaenens (UGent)
- Organization
- Abstract
- The adverse effects of personalized toxicity are in an intricate balance with the intended efficacy of personalized medicine, but they are equally important in terms of other exposures like nutrition and environment. Intuitively, “personalized” refers to the unique genomic sequence of each individual. Yet, on top of that, the life history of each individual is equally unique and is imprinted onto the genome as epigenetic changes. Therefore, the early realization is establishing that epigenetics has a large effect on personalized toxicity. Here, rather than reviewing, we frame the evidence for pursuing this research avenue and highlight several cases and challenges for doing so. With sequencing technologies already well established, we end with a more detailed description of mass spectrometry (MS) as an important emerging tool in epigenetics, with a specific emphasis on the untargeted MS based analysis of the very dynamic histone code.
- Keywords
- Exposure, Adverse drug response, Toxicoepigenetics, Toxicology, Histones, Mass spectrometry, Environment, Personalized medicine, High throughput screening
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J3YPPTA5E1JZ6MM7RCR52SWR
- MLA
- Corveleyn, Laura, et al. “Epigenetics in Personalized Toxicity.” Personalized Epigenetics : A Volume in Translational Epigenetics, edited by Trygve Tollefsbol, Academic Press, 2024, pp. 229–48, doi:10.1016/b978-0-443-23802-4.00022-3.
- APA
- Corveleyn, L., Verhelst, S., Deforce, D., & Dhaenens, M. (2024). Epigenetics in personalized toxicity. In T. Tollefsbol (Ed.), Personalized epigenetics : a volume in translational epigenetics (pp. 229–248). https://doi.org/10.1016/b978-0-443-23802-4.00022-3
- Chicago author-date
- Corveleyn, Laura, Sigrid Verhelst, Dieter Deforce, and Maarten Dhaenens. 2024. “Epigenetics in Personalized Toxicity.” In Personalized Epigenetics : A Volume in Translational Epigenetics, edited by Trygve Tollefsbol, 229–48. Academic Press. https://doi.org/10.1016/b978-0-443-23802-4.00022-3.
- Chicago author-date (all authors)
- Corveleyn, Laura, Sigrid Verhelst, Dieter Deforce, and Maarten Dhaenens. 2024. “Epigenetics in Personalized Toxicity.” In Personalized Epigenetics : A Volume in Translational Epigenetics, ed by. Trygve Tollefsbol, 229–248. Academic Press. doi:10.1016/b978-0-443-23802-4.00022-3.
- Vancouver
- 1.Corveleyn L, Verhelst S, Deforce D, Dhaenens M. Epigenetics in personalized toxicity. In: Tollefsbol T, editor. Personalized epigenetics : a volume in translational epigenetics. Academic Press; 2024. p. 229–48.
- IEEE
- [1]L. Corveleyn, S. Verhelst, D. Deforce, and M. Dhaenens, “Epigenetics in personalized toxicity,” in Personalized epigenetics : a volume in translational epigenetics, T. Tollefsbol, Ed. Academic Press, 2024, pp. 229–248.
@incollection{01J3YPPTA5E1JZ6MM7RCR52SWR,
abstract = {{The adverse effects of personalized toxicity are in an intricate balance with the intended efficacy of personalized medicine, but they are equally important in terms of other exposures like nutrition and environment. Intuitively, “personalized” refers to the unique genomic sequence of each individual. Yet, on top of that, the life history of each individual is equally unique and is imprinted onto the genome as epigenetic changes. Therefore, the early realization is establishing that epigenetics has a large effect on personalized toxicity. Here, rather than reviewing, we frame the evidence for pursuing this research avenue and highlight several cases and challenges for doing so. With sequencing technologies already well established, we end with a more detailed description of mass spectrometry (MS) as an important emerging tool in epigenetics, with a specific emphasis on the untargeted MS based analysis of the very dynamic histone code.}},
author = {{Corveleyn, Laura and Verhelst, Sigrid and Deforce, Dieter and Dhaenens, Maarten}},
booktitle = {{Personalized epigenetics : a volume in translational epigenetics}},
editor = {{Tollefsbol, Trygve}},
isbn = {{9780443238024}},
keywords = {{Exposure,Adverse drug response,Toxicoepigenetics,Toxicology,Histones,Mass spectrometry,Environment,Personalized medicine,High throughput screening}},
language = {{eng}},
pages = {{229--248}},
publisher = {{Academic Press}},
title = {{Epigenetics in personalized toxicity}},
url = {{http://doi.org/10.1016/b978-0-443-23802-4.00022-3}},
year = {{2024}},
}
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