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Soft tissue tumor imaging in adults : whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects : guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR)

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Abstract
ObjectivesThe revised European Society of Musculoskeletal Radiology (ESSR) consensus guidelines on soft tissue tumor imaging represent an update of 2015 after technical advancements, further insights into specific entities, and revised World Health Organization (2020) and AJCC (2017) classifications. This second of three papers covers algorithms once histology is confirmed: (1) standardized whole-body staging, (2) special algorithms for non-malignant entities, and (3) multiplicity, genetic tumor syndromes, and pitfalls.Materials and methodsA validated Delphi method based on peer-reviewed literature was used to derive consensus among a panel of 46 specialized musculoskeletal radiologists from 12 European countries. Statements that had undergone interdisciplinary revision were scored online by the level of agreement (0 to 10) during two iterative rounds, that could result in 'group consensus', 'group agreement', or 'lack of agreement'.ResultsThe three sections contain 24 statements with comments. Group consensus was reached in 95.8% and group agreement in 4.2%. For whole-body staging, pulmonary MDCT should be performed in all high-grade sarcomas. Whole-body MRI is preferred for staging bone metastasis, with [18F]FDG-PET/CT as an alternative modality in PET-avid tumors. Patients with alveolar soft part sarcoma, clear cell sarcoma, and angiosarcoma should be screened for brain metastases. Special algorithms are recommended for entities such as rhabdomyosarcoma, extraskeletal Ewing sarcoma, myxoid liposarcoma, and neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors. Satisfaction of search should be avoided in potential multiplicity.ConclusionStandardized whole-body staging includes pulmonary MDCT in all high-grade sarcomas; entity-dependent modifications and specific algorithms are recommended for sarcomas and non-malignant soft tissue tumors.Clinical relevance statementThese updated ESSR soft tissue tumor imaging guidelines aim to provide support in decision-making, helping to avoid common pitfalls, by providing general and entity-specific algorithms, techniques, and reporting recommendations for whole-body staging in sarcoma and non-malignant soft tissue tumors.Key Points...
Keywords
Practice guideline, Consensus, Neoplasms, Connective and soft tissue, Diagnostic imaging, NERVE SHEATH TUMOR, LYMPH-NODE METASTASIS, MYXOID LIPOSARCOMA, DIAGNOSTIC-ACCURACY, PART SARCOMA, MRI, EXTREMITY, PET/CT, PATTERNS, FEATURES

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MLA
Noebauer-Huhmann, Iris-Melanie, et al. “Soft Tissue Tumor Imaging in Adults : Whole-Body Staging in Sarcoma, Non-Malignant Entities Requiring Special Algorithms, Pitfalls and Special Imaging Aspects : Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR).” EUROPEAN RADIOLOGY, 2024, doi:10.1007/s00330-024-10897-z.
APA
Noebauer-Huhmann, I.-M., Vanhoenacker, F., Vilanova, J. C., Tagliafico, A. S., Weber, M.-A., Lalam, R. K., … Bloem, J. L. (2024). Soft tissue tumor imaging in adults : whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects : guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR). EUROPEAN RADIOLOGY. https://doi.org/10.1007/s00330-024-10897-z
Chicago author-date
Noebauer-Huhmann, Iris-Melanie, Filip Vanhoenacker, Joan C. Vilanova, Alberto S. Tagliafico, Marc-André Weber, Radhesh K. Lalam, Thomas Grieser, et al. 2024. “Soft Tissue Tumor Imaging in Adults : Whole-Body Staging in Sarcoma, Non-Malignant Entities Requiring Special Algorithms, Pitfalls and Special Imaging Aspects : Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR).” EUROPEAN RADIOLOGY. https://doi.org/10.1007/s00330-024-10897-z.
Chicago author-date (all authors)
Noebauer-Huhmann, Iris-Melanie, Filip Vanhoenacker, Joan C. Vilanova, Alberto S. Tagliafico, Marc-André Weber, Radhesh K. Lalam, Thomas Grieser, Violeta Vasilevska Nikodinovska, Jacky W. J. de Rooy, Olympia Papakonstantinou, Catherine Mccarthy, Luca Maria Sconfienza, Koenraad Verstraete, José Martel-Villagrán, Pavol Szomolanyi, Frédéric E. Lecouvet, Diana Afonso, Omar M. Albtoush, Giacomo Aringhieri, Remide Arkun, Gunnar Aström, Alberto Bazzocchi, Rajesh Botchu, Martin Breitenseher, Snehansh Chaudhary, Danoob Dalili, Mark Davies, Milko C. de Jonge, Berna D. Mete, Jan Fritz, Jan L. M. A. Gielen, Geoff Hide, Amanda Isaac, Slavcho Ivanoski, Ramy M. Mansour, Lorenzo Muntaner-Gimbernat, Ana Navas, Paul O´Donnell, Şebnem Örgüç, Winston J. Rennie, Santiago Resano, Philip Robinson, Hatice T. Sanal, Simone A. J. Ter Horst, Kirsten van Langevelde, Klaus Wörtler, Marita Koelz, Joannis Panotopoulos, Reinhard Windhager, and Johan L. Bloem. 2024. “Soft Tissue Tumor Imaging in Adults : Whole-Body Staging in Sarcoma, Non-Malignant Entities Requiring Special Algorithms, Pitfalls and Special Imaging Aspects : Guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR).” EUROPEAN RADIOLOGY. doi:10.1007/s00330-024-10897-z.
Vancouver
1.
Noebauer-Huhmann I-M, Vanhoenacker F, Vilanova JC, Tagliafico AS, Weber M-A, Lalam RK, et al. Soft tissue tumor imaging in adults : whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects : guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR). EUROPEAN RADIOLOGY. 2024;
IEEE
[1]
I.-M. Noebauer-Huhmann et al., “Soft tissue tumor imaging in adults : whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects : guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR),” EUROPEAN RADIOLOGY, 2024.
@article{01J3R3WCA907X8P6R45E6ZRP85,
  abstract     = {{ObjectivesThe revised European Society of Musculoskeletal Radiology (ESSR) consensus guidelines on soft tissue tumor imaging represent an update of 2015 after technical advancements, further insights into specific entities, and revised World Health Organization (2020) and AJCC (2017) classifications. This second of three papers covers algorithms once histology is confirmed: (1) standardized whole-body staging, (2) special algorithms for non-malignant entities, and (3) multiplicity, genetic tumor syndromes, and pitfalls.Materials and methodsA validated Delphi method based on peer-reviewed literature was used to derive consensus among a panel of 46 specialized musculoskeletal radiologists from 12 European countries. Statements that had undergone interdisciplinary revision were scored online by the level of agreement (0 to 10) during two iterative rounds, that could result in 'group consensus', 'group agreement', or 'lack of agreement'.ResultsThe three sections contain 24 statements with comments. Group consensus was reached in 95.8% and group agreement in 4.2%. For whole-body staging, pulmonary MDCT should be performed in all high-grade sarcomas. Whole-body MRI is preferred for staging bone metastasis, with [18F]FDG-PET/CT as an alternative modality in PET-avid tumors. Patients with alveolar soft part sarcoma, clear cell sarcoma, and angiosarcoma should be screened for brain metastases. Special algorithms are recommended for entities such as rhabdomyosarcoma, extraskeletal Ewing sarcoma, myxoid liposarcoma, and neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors. Satisfaction of search should be avoided in potential multiplicity.ConclusionStandardized whole-body staging includes pulmonary MDCT in all high-grade sarcomas; entity-dependent modifications and specific algorithms are recommended for sarcomas and non-malignant soft tissue tumors.Clinical relevance statementThese updated ESSR soft tissue tumor imaging guidelines aim to provide support in decision-making, helping to avoid common pitfalls, by providing general and entity-specific algorithms, techniques, and reporting recommendations for whole-body staging in sarcoma and non-malignant soft tissue tumors.Key Points...}},
  author       = {{Noebauer-Huhmann, Iris-Melanie and Vanhoenacker, Filip and Vilanova, Joan C. and Tagliafico, Alberto S. and Weber, Marc-André and Lalam, Radhesh K. and Grieser, Thomas and Nikodinovska, Violeta Vasilevska and de Rooy, Jacky W. J. and Papakonstantinou, Olympia and Mccarthy, Catherine and Sconfienza, Luca Maria and Verstraete, Koenraad and Martel-Villagrán, José and Szomolanyi, Pavol and Lecouvet, Frédéric E. and Afonso, Diana and Albtoush, Omar M. and Aringhieri, Giacomo and Arkun, Remide and Aström, Gunnar and Bazzocchi, Alberto and Botchu, Rajesh and Breitenseher, Martin and Chaudhary, Snehansh and Dalili, Danoob and Davies, Mark and de Jonge, Milko C. and Mete, Berna D. and Fritz, Jan and Gielen, Jan L. M. A. and Hide, Geoff and Isaac, Amanda and Ivanoski, Slavcho and Mansour, Ramy M. and Muntaner-Gimbernat, Lorenzo and Navas, Ana and O´Donnell, Paul and Örgüç, Şebnem and Rennie, Winston J. and Resano, Santiago and Robinson, Philip and Sanal, Hatice T. and Ter Horst, Simone A. J. and van Langevelde, Kirsten and Wörtler, Klaus and Koelz, Marita and Panotopoulos, Joannis and Windhager, Reinhard and Bloem, Johan L.}},
  issn         = {{0938-7994}},
  journal      = {{EUROPEAN RADIOLOGY}},
  keywords     = {{Practice guideline,Consensus,Neoplasms,Connective and soft tissue,Diagnostic imaging,NERVE SHEATH TUMOR,LYMPH-NODE METASTASIS,MYXOID LIPOSARCOMA,DIAGNOSTIC-ACCURACY,PART SARCOMA,MRI,EXTREMITY,PET/CT,PATTERNS,FEATURES}},
  language     = {{eng}},
  pages        = {{9}},
  title        = {{Soft tissue tumor imaging in adults : whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects : guidelines 2024 from the European Society of Musculoskeletal Radiology (ESSR)}},
  url          = {{http://doi.org/10.1007/s00330-024-10897-z}},
  year         = {{2024}},
}

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