@article{01J3AMXTGN44Q5ZPW8CJJ3Z44W,
  abstract     = {{Introduction Dynamic contrast-enhanced (DCE) MRI and arterial spin labeling (ASL) MRI enable non-invasive measurement of renal blood flow (RBF), whereas blood oxygenation level-dependent (BOLD) MRI enables non-invasive measurement of the apparent relaxation rate (R2*), an indicator of oxygenation. This study was conducted to evaluate the potential role of these MRI modalities in assessing RBF and oxygenation in dogs. The correlation between contrast-enhanced ultrasound (CEUS) and the MRI modalities was examined and also the ability of the MRI modalities to detect pharmacologically induced changes.Methods RBF, using CEUS, ASL- and DCE-MRI, as well as renal oxygenation, using BOLD-MRI of eight adult beagles were assessed at two time-points, 2-3 weeks apart. During each time point, the anesthetized dogs received either a control (0.9% sodium chloride) or a dopamine treatment. For each time point, measurements were carried out over 2 days. An MRI scan at 3 T was performed on day one, followed by CEUS on day two.Results Using the model-free model with caudal placement of the arterial input function (AIF) region of interest (ROI) in the aorta, the DCE results showed a significant correlation with ASL measured RBF and detected significant changes in blood flow during dopamine infusion. Additionally, R2* negatively correlated with ASL measured RBF at the cortex and medulla, as well as with medullary wash-in rate (WiR) and peak intensity (PI). ASL measured RBF, in its turn, showed a positive correlation with cortical WiR, PI, area under the curve (AUC) and fall time (FT), and with medullary WiR and PI, but a negative correlation with medullary rise time (RT). During dopamine infusion, BOLD-MRI observed a significant decrease in R2* at the medulla and entire kidney, while ASL-MRI demonstrated a significant increase in RBF at the cortex, medulla and the entire kidney.Conclusion ASL- and BOLD-MRI can measure pharmacologically induced changes in renal blood flow and renal oxygenation in dogs and might allow detection of changes that cannot be observed with CEUS. However, further research is needed to confirm the potential of ASL- and BOLD-MRI in dogs and to clarify which analysis method is most suitable for DCE-MRI in dogs.}},
  articleno    = {{1406343}},
  author       = {{Hillaert, Amber and Sanmiguel Serpa, Luis Carlos and Bogaert, Stephanie and Broeckx, Bart and Hesta, Myriam and Vandermeulen, Eva and Germonpré, Jolien and Stock, Emmelie and Pullens, Pim and Vanderperren, Katrien}},
  editor       = {{Banzato, Tommaso}},
  issn         = {{2297-1769}},
  journal      = {{FRONTIERS IN VETERINARY SCIENCE}},
  keywords     = {{kidney,perfusion,oxygenation,ASL-MRI,BOLD-MRI,DCE-MRI,CEUS,dog,GLOMERULAR-FILTRATION-RATE,RENAL PERFUSION,BOLD-MRI,BLOOD-FLOW,PLASMA-CLEARANCE,RAT-KIDNEY,DOPAMINE,QUANTIFICATION,OXYGENATION,AGENT}},
  language     = {{eng}},
  pages        = {{16}},
  title        = {{Assessment of pharmacologically induced changes in canine kidney function by multiparametric magnetic resonance imaging and contrast enhanced ultrasound}},
  url          = {{http://doi.org/10.3389/fvets.2024.1406343}},
  volume       = {{11}},
  year         = {{2024}},
}

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