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The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots

Paul B. Larsen, Shiyang He, Taylor J. Meyer, Miriam Szurman‐Zubrzycka, Carolin Alfs, Jolanta Kwasniewska, Alexandra Pervis, Monika Gajecka, Aishwarya Veerabahu, Taylor R. Beaulieu, et al.
(2024) PLANT CELL AND ENVIRONMENT. 47(11). p.4432-4448
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Abstract
Aluminum-dependent stoppage of root growth requires the DNA damage response (DDR) pathway including the p53-like transcription factor SUPPRESSOR OF GAMMA RADIATION 1 (SOG1), which promotes terminal differentiation of the root tip in response to Al dependent cell death. Transcriptomic analyses identified Al-induced SOG1-regulated targets as candidate mediators of this growth arrest. Analysis of these factors either as loss-of-function mutants or by overexpression in the als3-1 background shows ERF115, which is a key transcription factor that in other scenarios is rate-limiting for damaged stem cell replenishment, instead participates in transition from an actively growing root to one that has terminally differentiated in response to Al toxicity. This is supported by a loss-of-function erf115 mutant raising the threshold of Al required to promote terminal differentiation of Al hypersensitive als3-1. Consistent with its key role in stoppage of root growth, a putative ERF115 barley ortholog is also upregulated following Al exposure, suggesting a conserved role for this ATR-dependent pathway in Al response. In contrast to other DNA damage agents, these results show that ERF115 and likely related family members are important determinants of terminal differentiation of the root tip following Al exposure and central outputs of the SOG1-mediated pathway in Al response.
Keywords
ATR, DNA damage, ERF115, SOG1, aluminium, aluminum, DNA-DAMAGE RESPONSE, PHOSPHATE DEFICIENCY, CYCLE CHECKPOINT, GROWTH INHIBITION, AL TOXICITY, TRANSPORTER, ENCODES, TOLERANCE, GENES

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Citation

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MLA
Larsen, Paul B., et al. “The Stem Cell Niche Transcription Factor ETHYLENE RESPONSE FACTOR 115 Participates in Aluminum‐induced Terminal Differentiation in Arabidopsis Roots.” PLANT CELL AND ENVIRONMENT, vol. 47, no. 11, 2024, pp. 4432–48, doi:10.1111/pce.15032.
APA
Larsen, P. B., He, S., Meyer, T. J., Szurman‐Zubrzycka, M., Alfs, C., Kwasniewska, J., … Murn, J. (2024). The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots. PLANT CELL AND ENVIRONMENT, 47(11), 4432–4448. https://doi.org/10.1111/pce.15032
Chicago author-date
Larsen, Paul B., Shiyang He, Taylor J. Meyer, Miriam Szurman‐Zubrzycka, Carolin Alfs, Jolanta Kwasniewska, Alexandra Pervis, et al. 2024. “The Stem Cell Niche Transcription Factor ETHYLENE RESPONSE FACTOR 115 Participates in Aluminum‐induced Terminal Differentiation in Arabidopsis Roots.” PLANT CELL AND ENVIRONMENT 47 (11): 4432–48. https://doi.org/10.1111/pce.15032.
Chicago author-date (all authors)
Larsen, Paul B., Shiyang He, Taylor J. Meyer, Miriam Szurman‐Zubrzycka, Carolin Alfs, Jolanta Kwasniewska, Alexandra Pervis, Monika Gajecka, Aishwarya Veerabahu, Taylor R. Beaulieu, Stephen C. Bolaris, Thomas Eekhout, Lieven De Veylder, Steffen Abel, Iwona Szarejko, and Jernej Murn. 2024. “The Stem Cell Niche Transcription Factor ETHYLENE RESPONSE FACTOR 115 Participates in Aluminum‐induced Terminal Differentiation in Arabidopsis Roots.” PLANT CELL AND ENVIRONMENT 47 (11): 4432–4448. doi:10.1111/pce.15032.
Vancouver
1.
Larsen PB, He S, Meyer TJ, Szurman‐Zubrzycka M, Alfs C, Kwasniewska J, et al. The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots. PLANT CELL AND ENVIRONMENT. 2024;47(11):4432–48.
IEEE
[1]
P. B. Larsen et al., “The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots,” PLANT CELL AND ENVIRONMENT, vol. 47, no. 11, pp. 4432–4448, 2024.
@article{01J2ZYQK3GCENX0NT7ZT0WPRYR,
  abstract     = {{Aluminum-dependent stoppage of root growth requires the DNA damage response (DDR) pathway including the p53-like transcription factor SUPPRESSOR OF GAMMA RADIATION 1 (SOG1), which promotes terminal differentiation of the root tip in response to Al dependent cell death. Transcriptomic analyses identified Al-induced SOG1-regulated targets as candidate mediators of this growth arrest. Analysis of these factors either as loss-of-function mutants or by overexpression in the als3-1 background shows ERF115, which is a key transcription factor that in other scenarios is rate-limiting for damaged stem cell replenishment, instead participates in transition from an actively growing root to one that has terminally differentiated in response to Al toxicity. This is supported by a loss-of-function erf115 mutant raising the threshold of Al required to promote terminal differentiation of Al hypersensitive als3-1. Consistent with its key role in stoppage of root growth, a putative ERF115 barley ortholog is also upregulated following Al exposure, suggesting a conserved role for this ATR-dependent pathway in Al response. In contrast to other DNA damage agents, these results show that ERF115 and likely related family members are important determinants of terminal differentiation of the root tip following Al exposure and central outputs of the SOG1-mediated pathway in Al response.}},
  author       = {{Larsen, Paul B. and He, Shiyang and Meyer, Taylor J. and Szurman‐Zubrzycka, Miriam and Alfs, Carolin and Kwasniewska, Jolanta and Pervis, Alexandra and Gajecka, Monika and Veerabahu, Aishwarya and Beaulieu, Taylor R. and Bolaris, Stephen C. and Eekhout, Thomas and De Veylder, Lieven and Abel, Steffen and Szarejko, Iwona and Murn, Jernej}},
  issn         = {{0140-7791}},
  journal      = {{PLANT CELL AND ENVIRONMENT}},
  keywords     = {{ATR,DNA damage,ERF115,SOG1,aluminium,aluminum,DNA-DAMAGE RESPONSE,PHOSPHATE DEFICIENCY,CYCLE CHECKPOINT,GROWTH INHIBITION,AL TOXICITY,TRANSPORTER,ENCODES,TOLERANCE,GENES}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{4432--4448}},
  title        = {{The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots}},
  url          = {{http://doi.org/10.1111/pce.15032}},
  volume       = {{47}},
  year         = {{2024}},
}
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