Advanced search
1 file | 3.16 MB Add to list

A pilot study on the impact of parenteral vaccination of free-roaming dogs within the rabies control framework in Ukraine

Author
Organization
Abstract
This pioneering study is prompted by the imperative to enhance our understanding of a constituent with-in Ukraine's rabies control strategy, specifically focusing on the vaccination of free-roaming canines against rabies with a local vaccine in certain endemic rabies areas. The cross-sectional study encompassed the cap-ture, sterilization, deworming, and rabies vaccination processes in 160 free-roaming dogs, followed by the collection of blood samples to examine RABV-specific neutralising antibodies in 16 dogs (10% of the vac-cinated population), captured from sectors (territories) with a higher density of population and with higher density of previously vaccinated free-roaming dogs. Half of the targeted samples comprised males (n = 8), while the remaining half consisted of females (n = 8). The median of virus-neutralising antibody level was 0.58 IU/mL, with a minimum protective threshold of 0.5 IU/mL. Antibody titers below the 0.5 IU/mL thre-shold were detected in 25.0% (2/8) of the male group, and in 62.5% (5/8) of the female group. Notably, male dogs exhibited a higher median antibody level of 0.66 IU/mL, compared to females, who presented a median level of 0.26 IU/mL. However, no statistically significant difference was found between the male and femalegroups (P = 0.36). In general, more than half of the tested population (56.3%) exceeded the 0.5 IU/mL pro-tective threshold 4 months post-vaccination. The inadequate levels of antibodies neutralizing the rabies virus are likely a result of a confluence of factors, including stressors such as nutritional and temperature-related challenges, along with variations in the responses of individual immune systems. Considering the endemic rabies situation and large population of free-roaming dogs in Ukraine, we suggest repeated vaccination for free-roaming dogs against rabies one year after the previous vaccination. In perspective, we suggest conduct-ing large-scale epidemiological studies to assess the impact of animal-related, vaccine-related, and environ-ment-related parameters on the efficacy of rabies vaccines used in Ukraine
Keywords
FAVN, immunity response, neutralising antibody, One Health\, rabies epidemic, stray dogs', vaccination campaigns

Downloads

  • A pilot study JDW RMB 2024.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 3.16 MB

Citation

Please use this url to cite or link to this publication:

MLA
Makovska, Iryna, et al. “A Pilot Study on the Impact of Parenteral Vaccination of Free-Roaming Dogs within the Rabies Control Framework in Ukraine.” REGULATORY MECHANISMS IN BIOSYSTEMS, vol. 15, no. 1, Oles Honchar Dnipropetrovsk Natl Univ, 2024, pp. 177–82, doi:10.15421/022426.
APA
Makovska, I., Tsarenko, T. M., Cliquet, F., Dhaka, P., Korniienko, L. Y., Tabakovski, B., … Dewulf, J. (2024). A pilot study on the impact of parenteral vaccination of free-roaming dogs within the rabies control framework in Ukraine. REGULATORY MECHANISMS IN BIOSYSTEMS, 15(1), 177–182. https://doi.org/10.15421/022426
Chicago author-date
Makovska, Iryna, T. M. Tsarenko, F. Cliquet, P. Dhaka, L. Y. Korniienko, B. Tabakovski, Ilias Chantziaras, and Jeroen Dewulf. 2024. “A Pilot Study on the Impact of Parenteral Vaccination of Free-Roaming Dogs within the Rabies Control Framework in Ukraine.” REGULATORY MECHANISMS IN BIOSYSTEMS 15 (1): 177–82. https://doi.org/10.15421/022426.
Chicago author-date (all authors)
Makovska, Iryna, T. M. Tsarenko, F. Cliquet, P. Dhaka, L. Y. Korniienko, B. Tabakovski, Ilias Chantziaras, and Jeroen Dewulf. 2024. “A Pilot Study on the Impact of Parenteral Vaccination of Free-Roaming Dogs within the Rabies Control Framework in Ukraine.” REGULATORY MECHANISMS IN BIOSYSTEMS 15 (1): 177–182. doi:10.15421/022426.
Vancouver
1.
Makovska I, Tsarenko TM, Cliquet F, Dhaka P, Korniienko LY, Tabakovski B, et al. A pilot study on the impact of parenteral vaccination of free-roaming dogs within the rabies control framework in Ukraine. REGULATORY MECHANISMS IN BIOSYSTEMS. 2024;15(1):177–82.
IEEE
[1]
I. Makovska et al., “A pilot study on the impact of parenteral vaccination of free-roaming dogs within the rabies control framework in Ukraine,” REGULATORY MECHANISMS IN BIOSYSTEMS, vol. 15, no. 1, pp. 177–182, 2024.
@article{01J2BY257XEHF0Y3TBAD96ZZPF,
  abstract     = {{This pioneering study is prompted by the imperative to enhance our understanding of a constituent with-in Ukraine's rabies control strategy, specifically focusing on the vaccination of free-roaming canines against rabies with a local vaccine in certain endemic rabies areas. The cross-sectional study encompassed the cap-ture, sterilization, deworming, and rabies vaccination processes in 160 free-roaming dogs, followed by the collection of blood samples to examine RABV-specific neutralising antibodies in 16 dogs (10% of the vac-cinated population), captured from sectors (territories) with a higher density of population and with higher density of previously vaccinated free-roaming dogs. Half of the targeted samples comprised males (n = 8), while the remaining half consisted of females (n = 8). The median of virus-neutralising antibody level was 0.58 IU/mL, with a minimum protective threshold of 0.5 IU/mL. Antibody titers below the 0.5 IU/mL thre-shold were detected in 25.0% (2/8) of the male group, and in 62.5% (5/8) of the female group. Notably, male dogs exhibited a higher median antibody level of 0.66 IU/mL, compared to females, who presented a median level of 0.26 IU/mL. However, no statistically significant difference was found between the male and femalegroups (P = 0.36). In general, more than half of the tested population (56.3%) exceeded the 0.5 IU/mL pro-tective threshold 4 months post-vaccination. The inadequate levels of antibodies neutralizing the rabies virus are likely a result of a confluence of factors, including stressors such as nutritional and temperature-related challenges, along with variations in the responses of individual immune systems. Considering the endemic rabies situation and large population of free-roaming dogs in Ukraine, we suggest repeated vaccination for free-roaming dogs against rabies one year after the previous vaccination. In perspective, we suggest conduct-ing large-scale epidemiological studies to assess the impact of animal-related, vaccine-related, and environ-ment-related parameters on the efficacy of rabies vaccines used in Ukraine}},
  author       = {{Makovska, Iryna and  Tsarenko, T. M. and  Cliquet, F. and  Dhaka, P. and  Korniienko, L. Y. and  Tabakovski, B. and Chantziaras, Ilias and Dewulf, Jeroen}},
  issn         = {{2519-8521}},
  journal      = {{REGULATORY MECHANISMS IN BIOSYSTEMS}},
  keywords     = {{FAVN,immunity response,neutralising antibody,One Health\,rabies epidemic,stray dogs',vaccination campaigns}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{177--182}},
  publisher    = {{Oles Honchar Dnipropetrovsk Natl Univ}},
  title        = {{A pilot study on the impact of parenteral vaccination of free-roaming dogs within the rabies control framework in Ukraine}},
  url          = {{http://doi.org/10.15421/022426}},
  volume       = {{15}},
  year         = {{2024}},
}

Altmetric
View in Altmetric