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Ultrastructural evidence of telocytes in the embryonic chick heart

Khan Junatas (UGent) , Liesbeth Couck (UGent) , Hanna Tay, Fred Sinowatz and Wim Van Den Broeck (UGent)
(2024) ANATOMIA HISTOLOGIA EMBRYOLOGIA. 53(1).
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Abstract
The cardiac telocyte (TC) is a novel interstitial cell type with a unique ultrastructure and great potential in therapy. The present study examined its presence in the heart of chicken embryos ageing 7-15 days old (Hamburger-Hamilton [HH] stages 31-41) using transmission electron microscopy. TCs were identified across all stages in the atrial and ventricular myocardium, close to maturing cardiomyocytes, blood vessels and lymphatics. Early-stage TCs have immature features resembling mesenchymal cells. Late-stage TCs were distinct, possessing the cytoplasmic prolongations termed telopodes (Tps), which are very long and thin, usually 1-3 in number, and display a moniliform appearance and have an average thickness below 0.2 & mu;m. TCs residing in the epicardium and endocardium were also detected. In the subepicardium near developing coronary vessels, they were localized in the cardiac stem cell niches, coexisting with cardiac stem cells and cardiomyocyte progenitors. Electron-dense structures and the release of extracellular vesicles were observed between embryonic TCs and surrounding structures, suggesting roles in intercellular communication, cardiomyocyte differentiation and maturation, angiogenesis, and stem cell nursing and guidance.
Keywords
chick, embryo, heart, morphogenesis, telocyte, telopode, CARDIAC TELOCYTES, CELLS ICLC, SUBEPICARDIAL MESENCHYME, MYOCARDIUM, TISSUE, IDENTIFICATION, CONTRIBUTE, PATTERNS, VESICLES, WALL

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MLA
Junatas, Khan, et al. “Ultrastructural Evidence of Telocytes in the Embryonic Chick Heart.” ANATOMIA HISTOLOGIA EMBRYOLOGIA, vol. 53, no. 1, Wiley, 2024, doi:10.1111/ahe.12970.
APA
Junatas, K., Couck, L., Tay, H., Sinowatz, F., & Van Den Broeck, W. (2024). Ultrastructural evidence of telocytes in the embryonic chick heart. ANATOMIA HISTOLOGIA EMBRYOLOGIA, 53(1). https://doi.org/10.1111/ahe.12970
Chicago author-date
Junatas, Khan, Liesbeth Couck, Hanna Tay, Fred Sinowatz, and Wim Van Den Broeck. 2024. “Ultrastructural Evidence of Telocytes in the Embryonic Chick Heart.” ANATOMIA HISTOLOGIA EMBRYOLOGIA 53 (1). https://doi.org/10.1111/ahe.12970.
Chicago author-date (all authors)
Junatas, Khan, Liesbeth Couck, Hanna Tay, Fred Sinowatz, and Wim Van Den Broeck. 2024. “Ultrastructural Evidence of Telocytes in the Embryonic Chick Heart.” ANATOMIA HISTOLOGIA EMBRYOLOGIA 53 (1). doi:10.1111/ahe.12970.
Vancouver
1.
Junatas K, Couck L, Tay H, Sinowatz F, Van Den Broeck W. Ultrastructural evidence of telocytes in the embryonic chick heart. ANATOMIA HISTOLOGIA EMBRYOLOGIA. 2024;53(1).
IEEE
[1]
K. Junatas, L. Couck, H. Tay, F. Sinowatz, and W. Van Den Broeck, “Ultrastructural evidence of telocytes in the embryonic chick heart,” ANATOMIA HISTOLOGIA EMBRYOLOGIA, vol. 53, no. 1, 2024.
@article{01J1CSCNPY9JYQ902FZ77Q0973,
  abstract     = {{The cardiac telocyte (TC) is a novel interstitial cell type with a unique ultrastructure and great potential in therapy. The present study examined its presence in the heart of chicken embryos ageing 7-15 days old (Hamburger-Hamilton [HH] stages 31-41) using transmission electron microscopy. TCs were identified across all stages in the atrial and ventricular myocardium, close to maturing cardiomyocytes, blood vessels and lymphatics. Early-stage TCs have immature features resembling mesenchymal cells. Late-stage TCs were distinct, possessing the cytoplasmic prolongations termed telopodes (Tps), which are very long and thin, usually 1-3 in number, and display a moniliform appearance and have an average thickness below 0.2 & mu;m. TCs residing in the epicardium and endocardium were also detected. In the subepicardium near developing coronary vessels, they were localized in the cardiac stem cell niches, coexisting with cardiac stem cells and cardiomyocyte progenitors. Electron-dense structures and the release of extracellular vesicles were observed between embryonic TCs and surrounding structures, suggesting roles in intercellular communication, cardiomyocyte differentiation and maturation, angiogenesis, and stem cell nursing and guidance.}},
  author       = {{Junatas, Khan and Couck, Liesbeth and Tay, Hanna and  Sinowatz, Fred and Van Den Broeck, Wim}},
  issn         = {{0340-2096}},
  journal      = {{ANATOMIA HISTOLOGIA EMBRYOLOGIA}},
  keywords     = {{chick,embryo,heart,morphogenesis,telocyte,telopode,CARDIAC TELOCYTES,CELLS ICLC,SUBEPICARDIAL MESENCHYME,MYOCARDIUM,TISSUE,IDENTIFICATION,CONTRIBUTE,PATTERNS,VESICLES,WALL}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{13}},
  publisher    = {{Wiley}},
  title        = {{Ultrastructural evidence of telocytes in the embryonic chick heart}},
  url          = {{http://doi.org/10.1111/ahe.12970}},
  volume       = {{53}},
  year         = {{2024}},
}
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