Immunogenicity of ferroptosis in cancer : a matter of context?
- Author
- Elena Catanzaro (UGent) , Robin Demuynck (UGent) , Faye Naessens (UGent) , Lorenzo Galluzzi and Dmitri Krysko (UGent)
- Organization
- Project
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- Harnessing tumor acidosis and immunogenic ferroptosis for an innovative treatment of peritoneal carcinomatosis with PUFA-loaded nanovesicles
- Generation of tumor neoantigens with photodynamic therapy: a new strategy for anticancer vaccines to fight head and neck cancer
- The impact of tumour vasculature on the immunogenicity of ferroptosis in tumour spheroids.
- Unravelling the role of immunogenic cell death and endothelial cells in the tumour microenvironment and immunity
- High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity
- Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapy
- Triple punch against melanoma: photodynamic therapy, immunogenic cell death and photothermal ablation
- Novel photosensitizers to push the limits of photodynamic cancer therapy
- IIMMUNO—FER—GUARD: Immunotherapy-based Modality Using Dendritic cells Loaded with FERroptotic cancer Lysates - Guarding against Glioblastoma and Melanoma
- Abstract
- Ferroptosis is a variant of regulated cell death (RCD) elicited by an imbalance of cellular redox homeostasis that culminates with extensive lipid peroxidation and rapid plasma membrane breakdown. Since other necrotic forms of RCD, such as necroptosis, are highly immunogenic, ferroptosis inducers have attracted considerable attention as potential tools to selectively kill malignant cells while eliciting therapeutically relevant tumor-targeting immune responses. However, rather than being consistently immunogenic, ferroptosis mediates context-dependent effects on anticancer immunity. The inability of ferroptotic cancer cells to elicit adaptive immune responses may arise from contextual deficiencies in intrinsic aspects of the process, such as adjuvanticity and antigenicity, or from microenvironmental defects imposed by ferroptotic cancer cells themselves or elicited by the induction of ferroptosis in immune cells. Copyright © 2024 Elsevier Inc. All rights reserved.
- Keywords
- DAMPs, GPX4, adjuvanticity, antigen-presenting cells, antigenicity, cytotoxic T lymphocytes, ferroptosis, immune checkpoint inhibitors, immunogenic cell death, tumor-associated macrophages
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01J06B1DDFTANP51GBDEWGRTHZ
- MLA
- Catanzaro, Elena, et al. “Immunogenicity of Ferroptosis in Cancer : A Matter of Context?” TRENDS IN CANCER, vol. 10, no. 5, 2024, pp. 407–16, doi:10.1016/j.trecan.2024.01.013.
- APA
- Catanzaro, E., Demuynck, R., Naessens, F., Galluzzi, L., & Krysko, D. (2024). Immunogenicity of ferroptosis in cancer : a matter of context? TRENDS IN CANCER, 10(5), 407–416. https://doi.org/10.1016/j.trecan.2024.01.013
- Chicago author-date
- Catanzaro, Elena, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, and Dmitri Krysko. 2024. “Immunogenicity of Ferroptosis in Cancer : A Matter of Context?” TRENDS IN CANCER 10 (5): 407–16. https://doi.org/10.1016/j.trecan.2024.01.013.
- Chicago author-date (all authors)
- Catanzaro, Elena, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, and Dmitri Krysko. 2024. “Immunogenicity of Ferroptosis in Cancer : A Matter of Context?” TRENDS IN CANCER 10 (5): 407–416. doi:10.1016/j.trecan.2024.01.013.
- Vancouver
- 1.Catanzaro E, Demuynck R, Naessens F, Galluzzi L, Krysko D. Immunogenicity of ferroptosis in cancer : a matter of context? TRENDS IN CANCER. 2024;10(5):407–16.
- IEEE
- [1]E. Catanzaro, R. Demuynck, F. Naessens, L. Galluzzi, and D. Krysko, “Immunogenicity of ferroptosis in cancer : a matter of context?,” TRENDS IN CANCER, vol. 10, no. 5, pp. 407–416, 2024.
@article{01J06B1DDFTANP51GBDEWGRTHZ,
abstract = {{Ferroptosis is a variant of regulated cell death (RCD) elicited by an imbalance of cellular redox homeostasis that culminates with extensive lipid peroxidation and rapid plasma membrane breakdown. Since other necrotic forms of RCD, such as necroptosis, are highly immunogenic, ferroptosis inducers have attracted considerable attention as potential tools to selectively kill malignant cells while eliciting therapeutically relevant tumor-targeting immune responses. However, rather than being consistently immunogenic, ferroptosis mediates context-dependent effects on anticancer immunity. The inability of ferroptotic cancer cells to elicit adaptive immune responses may arise from contextual deficiencies in intrinsic aspects of the process, such as adjuvanticity and antigenicity, or from microenvironmental defects imposed by ferroptotic cancer cells themselves or elicited by the induction of ferroptosis in immune cells. Copyright © 2024 Elsevier Inc. All rights reserved.}},
author = {{Catanzaro, Elena and Demuynck, Robin and Naessens, Faye and Galluzzi, Lorenzo and Krysko, Dmitri}},
issn = {{2405-8033}},
journal = {{TRENDS IN CANCER}},
keywords = {{DAMPs,GPX4,adjuvanticity,antigen-presenting cells,antigenicity,cytotoxic T lymphocytes,ferroptosis,immune checkpoint inhibitors,immunogenic cell death,tumor-associated macrophages}},
language = {{eng}},
number = {{5}},
pages = {{407--416}},
title = {{Immunogenicity of ferroptosis in cancer : a matter of context?}},
url = {{http://doi.org/10.1016/j.trecan.2024.01.013}},
volume = {{10}},
year = {{2024}},
}
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