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The role of hidden hearing loss in tinnitus : insights from early markers of peripheral hearing damage

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Abstract
Since the presence of tinnitus is not always associated with audiometric hearing loss, it has been hypothesized that hidden hearing loss may act as a potential trigger for increased central gain along the neural pathway leading to tinnitus perception. In recent years, the study of hidden hearing loss has improved with the discovery of cochlear synaptopathy and several objective diagnostic markers. This study investigated three potential markers of peripheral hidden hearing loss in subjects with tinnitus: extended high-frequency audiometric thresholds, the auditory brainstem response, and the envelope following response. In addition, speech intelligibility was measured as a functional outcome measurement of hidden hearing loss. To account for age-related hidden hearing loss, participants were grouped according to age, presence of tinnitus, and audiometric thresholds. Group comparisons were conducted to differentiate between age- and tinnitus-related effects of hidden hearing loss. All three markers revealed age-related differences, whereas no differences were observed between the tinnitus and non-tinnitus groups. However, the older tinnitus group showed improved performance on low-pass filtered speech in noise tests compared to the older non-tinnitus group. These low-pass speech in noise scores were significantly correlated with tinnitus distress, as indicated using questionnaires, and could be related to the presence of hyperacusis. Based on our observations, cochlear synaptopathy does not appear to be the underlying cause of tinnitus. The improvement in low-pass speech-in-noise could be explained by enhanced temporal fine structure encoding or hyperacusis. Therefore, we recommend that future tinnitus research takes into account age-related factors, explores low-frequency encoding, and thoroughly assesses hyperacusis.
Keywords
Tinnitus, Hidden hearing loss, Cochlear synaptopathy, Speech perception, Hyperacusis, NOISE EXPOSURE, COCHLEAR NEUROPATHY, AUDITORY-PERCEPTION, EVOKED-POTENTIALS, SPEECH-PERCEPTION, HYPERACUSIS, PREVALENCE, NERVE, SYNAPTOPATHY, DISORDERS

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Citation

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MLA
Devolder, Pauline, et al. “The Role of Hidden Hearing Loss in Tinnitus : Insights from Early Markers of Peripheral Hearing Damage.” HEARING RESEARCH, vol. 450, 2024, doi:10.1016/j.heares.2024.109050.
APA
Devolder, P., Keppler, H., Keshishzadeh, S., Taghon, B., Dhooge, I., & Verhulst, S. (2024). The role of hidden hearing loss in tinnitus : insights from early markers of peripheral hearing damage. HEARING RESEARCH, 450. https://doi.org/10.1016/j.heares.2024.109050
Chicago author-date
Devolder, Pauline, Hannah Keppler, Sarineh Keshishzadeh, Baziel Taghon, Ingeborg Dhooge, and Sarah Verhulst. 2024. “The Role of Hidden Hearing Loss in Tinnitus : Insights from Early Markers of Peripheral Hearing Damage.” HEARING RESEARCH 450. https://doi.org/10.1016/j.heares.2024.109050.
Chicago author-date (all authors)
Devolder, Pauline, Hannah Keppler, Sarineh Keshishzadeh, Baziel Taghon, Ingeborg Dhooge, and Sarah Verhulst. 2024. “The Role of Hidden Hearing Loss in Tinnitus : Insights from Early Markers of Peripheral Hearing Damage.” HEARING RESEARCH 450. doi:10.1016/j.heares.2024.109050.
Vancouver
1.
Devolder P, Keppler H, Keshishzadeh S, Taghon B, Dhooge I, Verhulst S. The role of hidden hearing loss in tinnitus : insights from early markers of peripheral hearing damage. HEARING RESEARCH. 2024;450.
IEEE
[1]
P. Devolder, H. Keppler, S. Keshishzadeh, B. Taghon, I. Dhooge, and S. Verhulst, “The role of hidden hearing loss in tinnitus : insights from early markers of peripheral hearing damage,” HEARING RESEARCH, vol. 450, 2024.
@article{01HZHPEG9D9X8SCJ5XGK67WDRN,
  abstract     = {{Since the presence of tinnitus is not always associated with audiometric hearing loss, it has been hypothesized that hidden hearing loss may act as a potential trigger for increased central gain along the neural pathway leading to tinnitus perception. In recent years, the study of hidden hearing loss has improved with the discovery of cochlear synaptopathy and several objective diagnostic markers. This study investigated three potential markers of peripheral hidden hearing loss in subjects with tinnitus: extended high-frequency audiometric thresholds, the auditory brainstem response, and the envelope following response. In addition, speech intelligibility was measured as a functional outcome measurement of hidden hearing loss. To account for age-related hidden hearing loss, participants were grouped according to age, presence of tinnitus, and audiometric thresholds. Group comparisons were conducted to differentiate between age- and tinnitus-related effects of hidden hearing loss. All three markers revealed age-related differences, whereas no differences were observed between the tinnitus and non-tinnitus groups. However, the older tinnitus group showed improved performance on low-pass filtered speech in noise tests compared to the older non-tinnitus group. These low-pass speech in noise scores were significantly correlated with tinnitus distress, as indicated using questionnaires, and could be related to the presence of hyperacusis. Based on our observations, cochlear synaptopathy does not appear to be the underlying cause of tinnitus. The improvement in low-pass speech-in-noise could be explained by enhanced temporal fine structure encoding or hyperacusis. Therefore, we recommend that future tinnitus research takes into account age-related factors, explores low-frequency encoding, and thoroughly assesses hyperacusis.}},
  articleno    = {{109050}},
  author       = {{Devolder, Pauline and Keppler, Hannah and Keshishzadeh, Sarineh and Taghon, Baziel and Dhooge, Ingeborg and Verhulst, Sarah}},
  issn         = {{0378-5955}},
  journal      = {{HEARING RESEARCH}},
  keywords     = {{Tinnitus,Hidden hearing loss,Cochlear synaptopathy,Speech perception,Hyperacusis,NOISE EXPOSURE,COCHLEAR NEUROPATHY,AUDITORY-PERCEPTION,EVOKED-POTENTIALS,SPEECH-PERCEPTION,HYPERACUSIS,PREVALENCE,NERVE,SYNAPTOPATHY,DISORDERS}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{The role of hidden hearing loss in tinnitus : insights from early markers of peripheral hearing damage}},
  url          = {{http://doi.org/10.1016/j.heares.2024.109050}},
  volume       = {{450}},
  year         = {{2024}},
}

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