@article{01HZ6VP4AS5DS2XTFJFVGTHXC3,
  abstract     = {{Research on modulation of iodine uptake by thyroid cells could help
   improve radioiodine treatment of dogs with thyroid tumors. The aim of
   this study was to characterize the immunohistochemical expression of
   thyroid transcription factor-1 (TTF-1), thyroglobulin, thyrotropin
   receptor (TSHR), sodium iodide symporter (NIS), pendrin, thyroid
   peroxidase (TPO), vimentin, and Ki-67 in follicular cell thyroid
   carcinomas (FTCs) and medullary thyroid carcinomas (MTCs), and to
   compare protein expression between FTC causing hyperthyroidism and FTC
   of euthyroid dogs. Immunohistochemistry was performed in 25 FTCs (9
   follicular, 8 follicular-compact, and 8 compact) and 8 MTCs. FTCs and
   MTCs were positive for TTF-1, and expression was higher in FTCs of
   euthyroid dogs compared with FTCs of hyperthyroid dogs (P= .041).
   Immunolabeling for thyroglobulin was higher in follicular and
   follicular-compact FTCs compared with compact FTCs (P = .001), while
   vimentin expression was higher in follicular-compact FTCs compared with
   follicular FTCs (P = .011). The expression of TSHR, NIS, pendrin, and
   TPO was not significantly different among the different subtypes of FTCs
   or between FTCs causing hyperthyroidism and FTCs in euthyroid dogs.
   TSHR, NIS, pendrin, and TPO were also expressed in MTCs. Ki-67 labeling
   index was comparable between FTCs and MTCs, and between FTCs causing
   hyperthyroidism and FTCs in euthyroid dogs. Proteins of iodine transport
   were also expressed in canine MTCs, which could have implications for
   diagnosis and treatment. The different expression of thyroglobulin and
   vimentin between FTC histological subtypes could reflect variations in
   tumor differentiation.}},
  author       = {{Jankovic, Jana and Tieche, Eve and Dettwiler, Martina and Hahn, Kerstin and Scheemaeker, Stephanie and Kessler, Martin and Daminet, Sylvie and Rottenberg, Sven and Campos, Miguel}},
  issn         = {{0300-9858}},
  journal      = {{VETERINARY PATHOLOGY}},
  keywords     = {{dogs,follicular cell thyroid carcinoma,immunohistochemistry,iodine
   uptake,medullary thyroid carcinoma,pendrin,sodium iodide symporter,thyroid peroxidase,thyroid-stimulating hormone receptor,SODIUM-IODIDE SYMPORTER,RADIOACTIVE IODINE,EXPRESSION,DOGS,TUMORS,THYROGLOBULIN,PEROXIDASE,CANCER,CLASSIFICATION,CALCITONIN}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{524--533}},
  title        = {{Canine follicular cell and medullary thyroid carcinomas :  immunohistochemical characterization}},
  url          = {{http://doi.org/10.1177/03009858231217245}},
  volume       = {{61}},
  year         = {{2024}},
}

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