Experimental infection models and their usefulness for White Spot Syndrome Virus (WSSV) research in shrimp
- Author
- Natasja Cox (UGent) , Evelien De Swaef (UGent) , Mathias Corteel (UGent) , Wim Van Den Broeck (UGent) , Peter Bossier (UGent) , Hans Nauwynck (UGent) and João José Pereira Dantas Da Rocha Lima (UGent)
- Organization
- Project
- Abstract
- White spot syndrome virus (WSSV) is marked as one of the most economically devastating pathogens in shrimp aquaculture worldwide. Infection of cultured shrimp can lead to mass mortality (up to 100%). Although progress has been made, our understanding of WSSV’s infection process and the virus–host–environment interaction is far from complete. This in turn hinders the development of effective mitigation strategies against WSSV. Infection models occupy a crucial first step in the research flow that tries to elucidate the infectious disease process to develop new antiviral treatments. Moreover, since the establishment of continuous shrimp cell lines is a work in progress, the development and use of standardized in vivo infection models that reflect the host–pathogen interaction in shrimp is a necessity. This review critically examines key aspects of in vivo WSSV infection model development that are often overlooked, such as standardization, (post)larval quality, inoculum type and choice of inoculation procedure, housing conditions, and shrimp welfare considerations. Furthermore, the usefulness of experimental infection models for different lines of WSSV research will be discussed with the aim to aid researchers when choosing a suitable model for their research needs.
- Keywords
- white spot syndrome virus, infection models, virulence, pathogenesis, transmission, epidemiology, antivirals, immunomodulators, genetic selection, HEMATOPOIETIC NECROSIS VIRUS, PENAEUS-MONODON FABRICIUS, FRESH-WATER CRAYFISH, CELL-CULTURE-SYSTEM, SYNDROME-ASSOCIATED BACULOVIRUS, INNATE IMMUNE-SYSTEM, BLACK TIGER SHRIMP, YELLOW-HEAD VIRUS, SALINITY STRESS TEST, DOUBLE-STRANDED-RNA
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HYD1FEX4ZT552ZSF5MDPDCVR
- MLA
- Cox, Natasja, et al. “Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.” VIRUSES-BASEL, vol. 16, no. 5, 2024, doi:10.3390/v16050813.
- APA
- Cox, N., De Swaef, E., Corteel, M., Van Den Broeck, W., Bossier, P., Nauwynck, H., & Pereira Dantas Da Rocha Lima, J. J. (2024). Experimental infection models and their usefulness for White Spot Syndrome Virus (WSSV) research in shrimp. VIRUSES-BASEL, 16(5). https://doi.org/10.3390/v16050813
- Chicago author-date
- Cox, Natasja, Evelien De Swaef, Mathias Corteel, Wim Van Den Broeck, Peter Bossier, Hans Nauwynck, and João José Pereira Dantas Da Rocha Lima. 2024. “Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.” VIRUSES-BASEL 16 (5). https://doi.org/10.3390/v16050813.
- Chicago author-date (all authors)
- Cox, Natasja, Evelien De Swaef, Mathias Corteel, Wim Van Den Broeck, Peter Bossier, Hans Nauwynck, and João José Pereira Dantas Da Rocha Lima. 2024. “Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.” VIRUSES-BASEL 16 (5). doi:10.3390/v16050813.
- Vancouver
- 1.Cox N, De Swaef E, Corteel M, Van Den Broeck W, Bossier P, Nauwynck H, et al. Experimental infection models and their usefulness for White Spot Syndrome Virus (WSSV) research in shrimp. VIRUSES-BASEL. 2024;16(5).
- IEEE
- [1]N. Cox et al., “Experimental infection models and their usefulness for White Spot Syndrome Virus (WSSV) research in shrimp,” VIRUSES-BASEL, vol. 16, no. 5, 2024.
@article{01HYD1FEX4ZT552ZSF5MDPDCVR,
abstract = {{White spot syndrome virus (WSSV) is marked as one of the most economically devastating pathogens in shrimp aquaculture worldwide. Infection of cultured shrimp can lead to mass mortality (up to 100%). Although progress has been made, our understanding of WSSV’s infection process and the virus–host–environment interaction is far from complete. This in turn hinders the development of effective mitigation strategies against WSSV. Infection models occupy a crucial first step in the research flow that tries to elucidate the infectious disease process to develop new antiviral treatments. Moreover, since the establishment of continuous shrimp cell lines is a work in progress, the development and use of standardized in vivo infection models that reflect the host–pathogen interaction in shrimp is a necessity. This review critically examines key aspects of in vivo WSSV infection model development that are often overlooked, such as standardization, (post)larval quality, inoculum type and choice of inoculation procedure, housing conditions, and shrimp welfare considerations. Furthermore, the usefulness of experimental infection models for different lines of WSSV research will be discussed with the aim to aid researchers when choosing a suitable model for their research needs.}},
articleno = {{813}},
author = {{Cox, Natasja and De Swaef, Evelien and Corteel, Mathias and Van Den Broeck, Wim and Bossier, Peter and Nauwynck, Hans and Pereira Dantas Da Rocha Lima, João José}},
issn = {{1999-4915}},
journal = {{VIRUSES-BASEL}},
keywords = {{white spot syndrome virus,infection models,virulence,pathogenesis,transmission,epidemiology,antivirals,immunomodulators,genetic selection,HEMATOPOIETIC NECROSIS VIRUS,PENAEUS-MONODON FABRICIUS,FRESH-WATER CRAYFISH,CELL-CULTURE-SYSTEM,SYNDROME-ASSOCIATED BACULOVIRUS,INNATE IMMUNE-SYSTEM,BLACK TIGER SHRIMP,YELLOW-HEAD VIRUS,SALINITY STRESS TEST,DOUBLE-STRANDED-RNA}},
language = {{eng}},
number = {{5}},
pages = {{39}},
title = {{Experimental infection models and their usefulness for White Spot Syndrome Virus (WSSV) research in shrimp}},
url = {{http://doi.org/10.3390/v16050813}},
volume = {{16}},
year = {{2024}},
}
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