Advanced search
1 file | 562.73 KB Add to list

Elective nodal irradiation for oligorecurrent nodal prostate cancer : interobserver variability in the PEACE V-STORM randomized phase 2 trial

Author
Organization
Abstract
Purpose: Consistency in delineation of pelvic lymph node regions for prostate cancer elective nodal radiation therapy is still challenging despite current guidelines. The aim of this study was to evaluate the interobserver variability in elective lymph node delineation in the PEACE V -STORM randomized phase 2 trial for oligorecurrent nodal prostate cancer. Methods and Materials: Twenty-three centers were asked to delineate the elective pelvic nodal clinical target volume (CTV) of a postoperative oligorecurrent nodal prostate cancer benchmark case using a modified Radiation Therapy Oncology Group (RTOG) 2009 template (upper limit at the L4/L5 interspace). Overall, intersection and overflow volumes, Dice coefficient, Hausdorff distance, and count maps merged with computed tomography images were analyzed. Results: The mean volume including the 23 nodal CTVs was 430.4 & PLUSMN; 64.1 cm3, larger than the modified RTOG 2009 CTV reference volume (386.1 cm3). The intersection common volume between the modified reference RTOG 2009 and the 23 nodal CTVs was estimated at 83.9%, whereas the overflow volume was 23.4%, mainly located at the level of the presacral and the upper limit of the L4/ L5 interspace. The mean Dice coefficient was 0.79 & PLUSMN; 0.02, whereas the mean Hausdorff distance was 27 & PLUSMN; 4.4 mm. Conclusions: In salvage radiation therapy treatment of oligorecurrent nodal prostate cancer, variations in elective lymph node volume delineation were mainly observed in the presacral and common iliac areas. Routine implementation and diffusion of available contouring guidelines together with a constant evaluation and evidence-based updating are expected to further decrease the existing variability in pelvic node contouring. & COPY; 2023 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Downloads

  • 1-s2.0-S2452109423001197-main.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 562.73 KB

Citation

Please use this url to cite or link to this publication:

MLA
Lorton, Orane, et al. “Elective Nodal Irradiation for Oligorecurrent Nodal Prostate Cancer : Interobserver Variability in the PEACE V-STORM Randomized Phase 2 Trial.” ADVANCES IN RADIATION ONCOLOGY, vol. 8, no. 6, 2023, doi:10.1016/j.adro.2023.101290.
APA
Lorton, O., Achard, V., Koutsouvelis, N., Jaccard, M., Vanhoutte, F., Dipasquale, G., … Zilli, T. (2023). Elective nodal irradiation for oligorecurrent nodal prostate cancer : interobserver variability in the PEACE V-STORM randomized phase 2 trial. ADVANCES IN RADIATION ONCOLOGY, 8(6). https://doi.org/10.1016/j.adro.2023.101290
Chicago author-date
Lorton, Orane, Verane Achard, Nikolaos Koutsouvelis, Maud Jaccard, Frederik Vanhoutte, Giovanna Dipasquale, Piet Ost, and Thomas Zilli. 2023. “Elective Nodal Irradiation for Oligorecurrent Nodal Prostate Cancer : Interobserver Variability in the PEACE V-STORM Randomized Phase 2 Trial.” ADVANCES IN RADIATION ONCOLOGY 8 (6). https://doi.org/10.1016/j.adro.2023.101290.
Chicago author-date (all authors)
Lorton, Orane, Verane Achard, Nikolaos Koutsouvelis, Maud Jaccard, Frederik Vanhoutte, Giovanna Dipasquale, Piet Ost, and Thomas Zilli. 2023. “Elective Nodal Irradiation for Oligorecurrent Nodal Prostate Cancer : Interobserver Variability in the PEACE V-STORM Randomized Phase 2 Trial.” ADVANCES IN RADIATION ONCOLOGY 8 (6). doi:10.1016/j.adro.2023.101290.
Vancouver
1.
Lorton O, Achard V, Koutsouvelis N, Jaccard M, Vanhoutte F, Dipasquale G, et al. Elective nodal irradiation for oligorecurrent nodal prostate cancer : interobserver variability in the PEACE V-STORM randomized phase 2 trial. ADVANCES IN RADIATION ONCOLOGY. 2023;8(6).
IEEE
[1]
O. Lorton et al., “Elective nodal irradiation for oligorecurrent nodal prostate cancer : interobserver variability in the PEACE V-STORM randomized phase 2 trial,” ADVANCES IN RADIATION ONCOLOGY, vol. 8, no. 6, 2023.
@article{01HY0E616R1E7S7X3H98XMQMYH,
  abstract     = {{Purpose: Consistency in delineation of pelvic lymph node regions for prostate cancer elective nodal radiation therapy is still challenging despite current guidelines. The aim of this study was to evaluate the interobserver variability in elective lymph node delineation in the PEACE V -STORM randomized phase 2 trial for oligorecurrent nodal prostate cancer. Methods and Materials: Twenty-three centers were asked to delineate the elective pelvic nodal clinical target volume (CTV) of a postoperative oligorecurrent nodal prostate cancer benchmark case using a modified Radiation Therapy Oncology Group (RTOG) 2009 template (upper limit at the L4/L5 interspace). Overall, intersection and overflow volumes, Dice coefficient, Hausdorff distance, and count maps merged with computed tomography images were analyzed. Results: The mean volume including the 23 nodal CTVs was 430.4 & PLUSMN; 64.1 cm3, larger than the modified RTOG 2009 CTV reference volume (386.1 cm3). The intersection common volume between the modified reference RTOG 2009 and the 23 nodal CTVs was estimated at 83.9%, whereas the overflow volume was 23.4%, mainly located at the level of the presacral and the upper limit of the L4/ L5 interspace. The mean Dice coefficient was 0.79 & PLUSMN; 0.02, whereas the mean Hausdorff distance was 27 & PLUSMN; 4.4 mm. Conclusions: In salvage radiation therapy treatment of oligorecurrent nodal prostate cancer, variations in elective lymph node volume delineation were mainly observed in the presacral and common iliac areas. Routine implementation and diffusion of available contouring guidelines together with a constant evaluation and evidence-based updating are expected to further decrease the existing variability in pelvic node contouring. & COPY; 2023 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).}},
  articleno    = {{101290}},
  author       = {{Lorton, Orane and  Achard, Verane and  Koutsouvelis, Nikolaos and  Jaccard, Maud and Vanhoutte, Frederik and  Dipasquale, Giovanna and Ost, Piet and  Zilli, Thomas}},
  issn         = {{2452-1094}},
  journal      = {{ADVANCES IN RADIATION ONCOLOGY}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{7}},
  title        = {{Elective nodal irradiation for oligorecurrent nodal prostate cancer : interobserver variability in the PEACE V-STORM randomized phase 2 trial}},
  url          = {{http://doi.org/10.1016/j.adro.2023.101290}},
  volume       = {{8}},
  year         = {{2023}},
}

Altmetric
View in Altmetric