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Modulation of broiler intestinal changes induced by Clostridium perfringens and deoxynivalenol through probiotic, paraprobiotic, and postbiotic supplementation

Marielen de Souza (UGent) , Ana Angelita Sampaio Baptista, Maísa Fabiana Menck-Costa, Larissa Justino, Eduardo Micotti da Glória, Gabriel Danilo Shimizu, Camila Rodrigues Ferraz, Waldiceu A. Verri, Filip Van Immerseel (UGent) and Ana Paula Frederico Rodrigues Loureiro Bracarense
(2024) TOXINS. 16(1).
Author
Organization
Abstract
Deoxynivalenol (DON) is a predisposing factor for necrotic enteritis. This study aimed to investigate the effects of a DON and Clostridium perfringens (CP) challenge on the intestinal morphology, morphometry, oxidative stress, and immune response of broilers. Additionally, we evaluated the potential of a Lactobacillus spp. mixture as an approach to mitigate the damage induced by the challenge. One-day-old broiler chickens (n = 252) were divided into seven treatment groups: Control, DON, CP, CP + DON, VL (DON + CP + viable Lactobacillus spp. mixture), HIL (DON + CP + heat-inactivated Lactobacillus spp. mixture), and LCS (DON + CP + Lactobacillus spp. mixture culture supernatant). Macroscopic evaluation of the intestines revealed that the CP + DON group exhibited the highest lesion score, while the VL and HIL groups showed the lowest scores. Microscopically, all Lactobacillus spp. treatments mitigated the morphological changes induced by the challenge. DON increased levels of reactive oxygen species (ROS) in the jejunum, and CP increased ROS levels in the jejunum and ileum. Notably, the Lactobacillus spp. treatments did not improve the antioxidant defense against CP-induced oxidative stress. In summary, a Lactobacillus spp. mixture, whether used as a probiotic, paraprobiotic, or postbiotic, exerted a partially protective effect in mitigating most of the intestinal damage induced by DON and CP challenges.
Keywords
necrotic enteritis, immunity, detoxification, mycotoxins, intestinal health

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MLA
de Souza, Marielen, et al. “Modulation of Broiler Intestinal Changes Induced by Clostridium Perfringens and Deoxynivalenol through Probiotic, Paraprobiotic, and Postbiotic Supplementation.” TOXINS, vol. 16, no. 1, 2024, doi:10.3390/toxins16010046.
APA
de Souza, M., Baptista, A. A. S., Menck-Costa, M. F., Justino, L., da Glória, E. M., Shimizu, G. D., … Bracarense, A. P. F. R. L. (2024). Modulation of broiler intestinal changes induced by Clostridium perfringens and deoxynivalenol through probiotic, paraprobiotic, and postbiotic supplementation. TOXINS, 16(1). https://doi.org/10.3390/toxins16010046
Chicago author-date
Souza, Marielen de, Ana Angelita Sampaio Baptista, Maísa Fabiana Menck-Costa, Larissa Justino, Eduardo Micotti da Glória, Gabriel Danilo Shimizu, Camila Rodrigues Ferraz, Waldiceu A. Verri, Filip Van Immerseel, and Ana Paula Frederico Rodrigues Loureiro Bracarense. 2024. “Modulation of Broiler Intestinal Changes Induced by Clostridium Perfringens and Deoxynivalenol through Probiotic, Paraprobiotic, and Postbiotic Supplementation.” TOXINS 16 (1). https://doi.org/10.3390/toxins16010046.
Chicago author-date (all authors)
de Souza, Marielen, Ana Angelita Sampaio Baptista, Maísa Fabiana Menck-Costa, Larissa Justino, Eduardo Micotti da Glória, Gabriel Danilo Shimizu, Camila Rodrigues Ferraz, Waldiceu A. Verri, Filip Van Immerseel, and Ana Paula Frederico Rodrigues Loureiro Bracarense. 2024. “Modulation of Broiler Intestinal Changes Induced by Clostridium Perfringens and Deoxynivalenol through Probiotic, Paraprobiotic, and Postbiotic Supplementation.” TOXINS 16 (1). doi:10.3390/toxins16010046.
Vancouver
1.
de Souza M, Baptista AAS, Menck-Costa MF, Justino L, da Glória EM, Shimizu GD, et al. Modulation of broiler intestinal changes induced by Clostridium perfringens and deoxynivalenol through probiotic, paraprobiotic, and postbiotic supplementation. TOXINS. 2024;16(1).
IEEE
[1]
M. de Souza et al., “Modulation of broiler intestinal changes induced by Clostridium perfringens and deoxynivalenol through probiotic, paraprobiotic, and postbiotic supplementation,” TOXINS, vol. 16, no. 1, 2024.
@article{01HWJP4DNSZ2QPCPRMGVHVK9MN,
  abstract     = {{Deoxynivalenol (DON) is a predisposing factor for necrotic enteritis. This study aimed to investigate the effects of a DON and Clostridium perfringens (CP) challenge on the intestinal morphology, morphometry, oxidative stress, and immune response of broilers. Additionally, we evaluated the potential of a Lactobacillus spp. mixture as an approach to mitigate the damage induced by the challenge. One-day-old broiler chickens (n = 252) were divided into seven treatment groups: Control, DON, CP, CP + DON, VL (DON + CP + viable Lactobacillus spp. mixture), HIL (DON + CP + heat-inactivated Lactobacillus spp. mixture), and LCS (DON + CP + Lactobacillus spp. mixture culture supernatant). Macroscopic evaluation of the intestines revealed that the CP + DON group exhibited the highest lesion score, while the VL and HIL groups showed the lowest scores. Microscopically, all Lactobacillus spp. treatments mitigated the morphological changes induced by the challenge. DON increased levels of reactive oxygen species (ROS) in the jejunum, and CP increased ROS levels in the jejunum and ileum. Notably, the Lactobacillus spp. treatments did not improve the antioxidant defense against CP-induced oxidative stress. In summary, a Lactobacillus spp. mixture, whether used as a probiotic, paraprobiotic, or postbiotic, exerted a partially protective effect in mitigating most of the intestinal damage induced by DON and CP challenges.}},
  articleno    = {{46}},
  author       = {{de Souza, Marielen and Baptista, Ana Angelita Sampaio and Menck-Costa, Maísa Fabiana and Justino, Larissa and da Glória, Eduardo Micotti and Shimizu, Gabriel Danilo and Ferraz, Camila Rodrigues and Verri, Waldiceu A. and Van Immerseel, Filip and Bracarense, Ana Paula Frederico Rodrigues Loureiro}},
  issn         = {{2072-6651}},
  journal      = {{TOXINS}},
  keywords     = {{necrotic enteritis,immunity,detoxification,mycotoxins,intestinal health}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{16}},
  title        = {{Modulation of broiler intestinal changes induced by Clostridium perfringens and deoxynivalenol through probiotic, paraprobiotic, and postbiotic supplementation}},
  url          = {{http://doi.org/10.3390/toxins16010046}},
  volume       = {{16}},
  year         = {{2024}},
}
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