Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile
- Author
- Inmaculada Sánchez-Vicente, Pablo Albertos, Carlos Sanz, Brecht Wybouw, Bert De Rybel (UGent) , Juan C Begara-Morales, Mounira Chaki, Capilla Mata-Pérez, Juan B Barroso and Oscar Lorenzo
- Organization
- Project
- Abstract
- Nitric oxide (NO) is a gasotransmitter required in a broad range of mechanisms controlling plant development and stress conditions. However, little is known about the specific role of this signaling molecule during lipid storage in the seeds. Here, we show that NO is accumulated in developing embryos and regulates the fatty acid profile through the stabilization of the basic/leucine zipper transcription factor bZIP67. NO and nitro-linolenic acid target and accumulate bZIP67 to induce the downstream expression of FAD3 desaturase, which is misregulated in a non-nitrosylable version of the protein. Moreover, the post-translational modification of bZIP67 is reversible by the trans-denitrosylation activity of peroxiredoxin IIE and defines a feedback mechanism for bZIP67 redox regulation. These findings provide a molecular framework to control the seed fatty acid profile caused by NO, and evidence of the in vivo functionality of nitro-fatty acids during plant developmental signaling.
- Keywords
- alkenal reductase, bZIP, fatty acid, gasotransmitter, nitric oxide, post-translational modification, redoxin, seed, transcription factor, ABSCISIC-ACID, SEED DORMANCY, TRANSCRIPTION FACTORS, ARABIDOPSIS-THALIANA, MOLECULAR-MECHANISM, SIGNALING PATHWAYS, GROWTH-INHIBITION, LINOLENIC ACID, GENE ACTIVITY, OXIDE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HWJCFC2Q8S55J88BDVQV3HJ5
- MLA
- Sánchez-Vicente, Inmaculada, et al. “Reversible S-Nitrosylation of BZIP67 by Peroxiredoxin IIE Activity and Nitro-Fatty Acids Regulates the Plant Lipid Profile.” CELL REPORTS, vol. 43, no. 4, 2024, doi:10.1016/j.celrep.2024.114091.
- APA
- Sánchez-Vicente, I., Albertos, P., Sanz, C., Wybouw, B., De Rybel, B., Begara-Morales, J. C., … Lorenzo, O. (2024). Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile. CELL REPORTS, 43(4). https://doi.org/10.1016/j.celrep.2024.114091
- Chicago author-date
- Sánchez-Vicente, Inmaculada, Pablo Albertos, Carlos Sanz, Brecht Wybouw, Bert De Rybel, Juan C Begara-Morales, Mounira Chaki, Capilla Mata-Pérez, Juan B Barroso, and Oscar Lorenzo. 2024. “Reversible S-Nitrosylation of BZIP67 by Peroxiredoxin IIE Activity and Nitro-Fatty Acids Regulates the Plant Lipid Profile.” CELL REPORTS 43 (4). https://doi.org/10.1016/j.celrep.2024.114091.
- Chicago author-date (all authors)
- Sánchez-Vicente, Inmaculada, Pablo Albertos, Carlos Sanz, Brecht Wybouw, Bert De Rybel, Juan C Begara-Morales, Mounira Chaki, Capilla Mata-Pérez, Juan B Barroso, and Oscar Lorenzo. 2024. “Reversible S-Nitrosylation of BZIP67 by Peroxiredoxin IIE Activity and Nitro-Fatty Acids Regulates the Plant Lipid Profile.” CELL REPORTS 43 (4). doi:10.1016/j.celrep.2024.114091.
- Vancouver
- 1.Sánchez-Vicente I, Albertos P, Sanz C, Wybouw B, De Rybel B, Begara-Morales JC, et al. Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile. CELL REPORTS. 2024;43(4).
- IEEE
- [1]I. Sánchez-Vicente et al., “Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile,” CELL REPORTS, vol. 43, no. 4, 2024.
@article{01HWJCFC2Q8S55J88BDVQV3HJ5,
abstract = {{Nitric oxide (NO) is a gasotransmitter required in a broad range of mechanisms controlling plant development and stress conditions. However, little is known about the specific role of this signaling molecule during lipid storage in the seeds. Here, we show that NO is accumulated in developing embryos and regulates the fatty acid profile through the stabilization of the basic/leucine zipper transcription factor bZIP67. NO and nitro-linolenic acid target and accumulate bZIP67 to induce the downstream expression of FAD3 desaturase, which is misregulated in a non-nitrosylable version of the protein. Moreover, the post-translational modification of bZIP67 is reversible by the trans-denitrosylation activity of peroxiredoxin IIE and defines a feedback mechanism for bZIP67 redox regulation. These findings provide a molecular framework to control the seed fatty acid profile caused by NO, and evidence of the in vivo functionality of nitro-fatty acids during plant developmental signaling.}},
articleno = {{114091}},
author = {{Sánchez-Vicente, Inmaculada and Albertos, Pablo and Sanz, Carlos and Wybouw, Brecht and De Rybel, Bert and Begara-Morales, Juan C and Chaki, Mounira and Mata-Pérez, Capilla and Barroso, Juan B and Lorenzo, Oscar}},
issn = {{2639-1856}},
journal = {{CELL REPORTS}},
keywords = {{alkenal reductase,bZIP,fatty acid,gasotransmitter,nitric oxide,post-translational modification,redoxin,seed,transcription factor,ABSCISIC-ACID,SEED DORMANCY,TRANSCRIPTION FACTORS,ARABIDOPSIS-THALIANA,MOLECULAR-MECHANISM,SIGNALING PATHWAYS,GROWTH-INHIBITION,LINOLENIC ACID,GENE ACTIVITY,OXIDE}},
language = {{eng}},
number = {{4}},
pages = {{21}},
title = {{Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile}},
url = {{http://doi.org/10.1016/j.celrep.2024.114091}},
volume = {{43}},
year = {{2024}},
}
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