@article{01HW86Z3F86C89EQYXVDWMV9WG,
  abstract     = {{Risk stratification using genetics and minimal residual disease (MRD) has allowed to increase the cure rates of pediatric acute myeloid leukemia (pedAML) up to 70% in contemporary protocols. Nevertheless, approximately 30% of patients still experience relapse, indicating a need to optimize stratification strategies. Recently, long non-coding RNA (lncRNA) expression has been shown to hold prognostic power in multiple cancer types. Here, we aimed at refining relapse prediction in pedAML using lncRNA expression. We built a relapse-related lncRNA prognostic signature, named AMLlnc69, using 871 pedAML patients transcriptomes obtained from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) repository. We identified a 69 lncRNA signature AMLlnc69 that is highly predictive of relapse-risk (c-index = 0.73), with area under the ROC curve (AUC) values for predicting the 1-, 2-, and 3-year relapse-free survival (RFS) of 0.78, 0.77, and 0.77, respectively. The internal validation using a bootstrap method (resampling times = 1000) resulted in a c-index of 0.72 and AUC values for predicting the 1-, 2-, and 3-year RFS of 0.77, 0.76, and 0.76, respectively. Through a Cox regression analysis, AMLlnc69, NPM mutation and WBC at diagnosis were identified as independent predictors of RFS. Finally, a nomogram was build using these two parameters, showing a c-index of 0.80 and 0.71 after bootstrapping (n =1000). In conclusion, the identified AMLlnc69 will, after prospective validation, add important information to guide management of pedAML patients. The nomogram is a promising tool for easy stratification of patients into a novel scheme of relapse-risk groups.}},
  author       = {{Ren, Zhiyao and Vanhooren, Jolien and Derpoorter, Charlotte and De Moerloose, Barbara and Lammens, Tim}},
  issn         = {{2473-9529}},
  journal      = {{BLOOD ADVANCES}},
  keywords     = {{ACUTE MYELOID-LEUKEMIA,FLOW-CYTOMETRY,EXPRESSION,ONCOLOGY,RESISTANCE,CHILDHOOD,CHILDREN,SURVIVAL,MODELS,RISK}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{3299--3310}},
  title        = {{A 69 long noncoding RNA signature predicts relapse and acts as independent prognostic factor in pediatric AML}},
  url          = {{http://doi.org/10.1182/bloodadvances.2024012667}},
  volume       = {{8}},
  year         = {{2024}},
}

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