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Investigating the cost-effectiveness of telemonitoring patients with cardiac implantable electronic devices : systematic review

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Abstract
Background: Telemonitoring patients with cardiac implantable electronic devices (CIEDs) can improve their care management. However, the results of cost-effectiveness studies are heterogeneous. Therefore, it is still a matter of debate whether telemonitoring is worth the investment. Objective: This systematic review aims to investigate the cost-effectiveness of telemonitoring patients with CIEDs, focusing on its key drivers, and the impact of the varying perspectives. Methods: A systematic review was performed in PubMed, Web of Science, Embase, and EconLit. The search was completed on July 7, 2022. Studies were included if they fulfilled the following criteria: patients had a CIED, comparison with standard care, and inclusion of health economic evaluations (eg, cost-effectiveness analyses and cost-utility analyses). Only complete and peer-reviewed studies were included, and no year limits were applied. The exclusion criteria included studies with partial economic evaluations, systematic reviews or reports, and studies without standard care as a control group. Besides general study characteristics, the following outcome measures were extracted: impact on total cost or income, cost or income drivers, cost or income drivers per patient, cost or income drivers as a percentage of the total cost impact, incremental cost-effectiveness ratios, or cost-utility ratios. Quality was assessed using the Consensus Health Economic Criteria checklist. Results: Overall, 15 cost-effectiveness analyses were included. All studies were performed in Western countries, mainly Europe, and had primarily a male participant population. Of the 15 studies, 3 (20%) calculated the incremental cost-effectiveness ratio, 1 (7%) the cost-utility ratio, and 11 (73%) the health and cost impact of telemonitoring. In total, 73% (11/15) of the studies indicated that telemonitoring of patients with implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy ICDs was cost-effective and cost-saving, both from a health care and patient perspective. Cost-effectiveness results for telemonitoring of patients with pacemakers were inconclusive. The key drivers for cost reduction from a health care perspective were hospitalizations and scheduled in-office visits. Hospitalization costs were reduced by up to US $912 per patient per year. Scheduled in-office visits included up to 61% of the total cost reduction. Key drivers for cost reduction from a patient perspective were loss of income, cost for scheduled in-office visits and transport. Finally, of the 15 studies, 8 (52%) reported improved quality of life, with statistically significance in only 1 (13%) study (P=.03). Conclusion: From a health care and patient perspective, telemonitoring of patients with an ICD or a cardiac resynchronization therapy ICD is a cost-effective and cost-saving alternative to standard care. Inconclusive results were found for patients with pacemakers. However, telemonitoring can lead to a decrease in providers' income, mainly due to a lack of reimbursement. Introducing appropriate reimbursement could make telemonitoring sustainable for providers while still being cost-effective from a health care payer perspective. PROSPERO CRD42022322334; https://tinyurl.com/puunapdr.
Keywords
systematic review, cost-effectiveness, telemonitoring, cardiac device, implantable cardioverter-defibrillator, ICD, pacemaker, monitoring, patient management, effectiveness, cost, quality of life, cardiac implantable electronic device, cardiac

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MLA
Raes, Sarah, et al. “Investigating the Cost-Effectiveness of Telemonitoring Patients with Cardiac Implantable Electronic Devices : Systematic Review.” JOURNAL OF MEDICAL INTERNET RESEARCH, vol. 26, 2024, doi:10.2196/47616.
APA
Raes, S., Prezzi, A., Willems, R., Heidbuchel, H., & Annemans, L. (2024). Investigating the cost-effectiveness of telemonitoring patients with cardiac implantable electronic devices : systematic review. JOURNAL OF MEDICAL INTERNET RESEARCH, 26. https://doi.org/10.2196/47616
Chicago author-date
Raes, Sarah, Andrea Prezzi, Rik Willems, Hein Heidbuchel, and Lieven Annemans. 2024. “Investigating the Cost-Effectiveness of Telemonitoring Patients with Cardiac Implantable Electronic Devices : Systematic Review.” JOURNAL OF MEDICAL INTERNET RESEARCH 26. https://doi.org/10.2196/47616.
Chicago author-date (all authors)
Raes, Sarah, Andrea Prezzi, Rik Willems, Hein Heidbuchel, and Lieven Annemans. 2024. “Investigating the Cost-Effectiveness of Telemonitoring Patients with Cardiac Implantable Electronic Devices : Systematic Review.” JOURNAL OF MEDICAL INTERNET RESEARCH 26. doi:10.2196/47616.
Vancouver
1.
Raes S, Prezzi A, Willems R, Heidbuchel H, Annemans L. Investigating the cost-effectiveness of telemonitoring patients with cardiac implantable electronic devices : systematic review. JOURNAL OF MEDICAL INTERNET RESEARCH. 2024;26.
IEEE
[1]
S. Raes, A. Prezzi, R. Willems, H. Heidbuchel, and L. Annemans, “Investigating the cost-effectiveness of telemonitoring patients with cardiac implantable electronic devices : systematic review,” JOURNAL OF MEDICAL INTERNET RESEARCH, vol. 26, 2024.
@article{01HW2DXYTMARR530WBN6A9H5BT,
  abstract     = {{Background: Telemonitoring patients with cardiac implantable electronic devices (CIEDs) can improve their care management. However, the results of cost-effectiveness studies are heterogeneous. Therefore, it is still a matter of debate whether telemonitoring is worth the investment. 

Objective: This systematic review aims to investigate the cost-effectiveness of telemonitoring patients with CIEDs, focusing on its key drivers, and the impact of the varying perspectives. 

Methods: A systematic review was performed in PubMed, Web of Science, Embase, and EconLit. The search was completed on July 7, 2022. Studies were included if they fulfilled the following criteria: patients had a CIED, comparison with standard care, and inclusion of health economic evaluations (eg, cost-effectiveness analyses and cost-utility analyses). Only complete and peer-reviewed studies were included, and no year limits were applied. The exclusion criteria included studies with partial economic evaluations, systematic reviews or reports, and studies without standard care as a control group. Besides general study characteristics, the following outcome measures were extracted: impact on total cost or income, cost or income drivers, cost or income drivers per patient, cost or income drivers as a percentage of the total cost impact, incremental cost-effectiveness ratios, or cost-utility ratios. Quality was assessed using the Consensus Health Economic Criteria checklist. 

Results: Overall, 15 cost-effectiveness analyses were included. All studies were performed in Western countries, mainly Europe, and had primarily a male participant population. Of the 15 studies, 3 (20%) calculated the incremental cost-effectiveness ratio, 1 (7%) the cost-utility ratio, and 11 (73%) the health and cost impact of telemonitoring. In total, 73% (11/15) of the studies indicated that telemonitoring of patients with implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy ICDs was cost-effective and cost-saving, both from a health care and patient perspective. Cost-effectiveness results for telemonitoring of patients with pacemakers were inconclusive. The key drivers for cost reduction from a health care perspective were hospitalizations and scheduled in-office visits. Hospitalization costs were reduced by up to US $912 per patient per year. Scheduled in-office visits included up to 61% of the total cost reduction. Key drivers for cost reduction from a patient perspective were loss of income, cost for scheduled in-office visits and transport. Finally, of the 15 studies, 8 (52%) reported improved quality of life, with statistically significance in only 1 (13%) study (P=.03). 

Conclusion: From a health care and patient perspective, telemonitoring of patients with an ICD or a cardiac resynchronization therapy ICD is a cost-effective and cost-saving alternative to standard care. Inconclusive results were found for patients with pacemakers. However, telemonitoring can lead to a decrease in providers' income, mainly due to a lack of reimbursement. Introducing appropriate reimbursement could make telemonitoring sustainable for providers while still being cost-effective from a health care payer perspective. 

PROSPERO CRD42022322334; https://tinyurl.com/puunapdr.}},
  articleno    = {{e47616}},
  author       = {{Raes, Sarah and Prezzi, Andrea and Willems, Rik and Heidbuchel, Hein and Annemans, Lieven}},
  issn         = {{1439-4456}},
  journal      = {{JOURNAL OF MEDICAL INTERNET RESEARCH}},
  keywords     = {{systematic review,cost-effectiveness,telemonitoring,cardiac device,implantable cardioverter-defibrillator,ICD,pacemaker,monitoring,patient management,effectiveness,cost,quality of life,cardiac implantable electronic device,cardiac}},
  language     = {{eng}},
  pages        = {{22}},
  title        = {{Investigating the cost-effectiveness of telemonitoring patients with cardiac implantable electronic devices : systematic review}},
  url          = {{http://doi.org/10.2196/47616}},
  volume       = {{26}},
  year         = {{2024}},
}

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