Evolutionary origin of Hoxc13-dependent skin appendages in amphibians
- Author
- Marjolein Carron (UGent) , Attila Placido Sachslehner, Münevver Burcu Cicekdal (UGent) , Inge Bruggeman (UGent) , Suzan Demuynck (UGent) , Bahar Golabi, Elfride De Baere (UGent) , Wim Declercq (UGent) , Erwin Tschachler, Kris Vleminckx (UGent) and Leopold Eckhart
- Organization
- Project
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- A novel CRISPR/Cas9-based workflow in Xenopus tropicalis to test the pathogenicity of human missense variants implicated in inherited blindness
- Precision medicine in inherited blindness using integrated omics in human and animal models
- Personalized functional genomics in Mendelian diseases: from DNA variants to clinical and bioethical implications
- Abstract
- Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of special intermediate filament proteins, known as hair keratins, which are expressed under the control of the transcription factor Hoxc13. Here, we show that the cornified claws of Xenopus frogs contain homologs of hair keratins and the genes encoding these keratins are flanked by promoters in which binding sites of Hoxc13 are conserved. Furthermore, these keratins and Hoxc13 are co-expressed in the claw-forming epithelium of frog toe tips. Upon deletion of hoxc13, the expression of hair keratin homologs is abolished and the development of cornified claws is abrogated in X. tropicalis. These results indicate that Hoxc13-dependent expression of hair keratin homologs evolved already in stem tetrapods, presumably as a mechanism for protecting toe tips, and that this ancestral genetic program was coopted to the growth of hair in mammals.
- Keywords
- BEST-FIT MODELS, PURE HAIR, HOXC13, EXPRESSION, GENES, DIVERSIFICATION, SELECTION, PROTEINS, PROTTEST, KERATINS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HTY9BTC9XVN1565PWAGWS44F
- MLA
- Carron, Marjolein, et al. “Evolutionary Origin of Hoxc13-Dependent Skin Appendages in Amphibians.” NATURE COMMUNICATIONS, vol. 15, no. 1, 2024, doi:10.1038/s41467-024-46373-x.
- APA
- Carron, M., Sachslehner, A. P., Cicekdal, M. B., Bruggeman, I., Demuynck, S., Golabi, B., … Eckhart, L. (2024). Evolutionary origin of Hoxc13-dependent skin appendages in amphibians. NATURE COMMUNICATIONS, 15(1). https://doi.org/10.1038/s41467-024-46373-x
- Chicago author-date
- Carron, Marjolein, Attila Placido Sachslehner, Münevver Burcu Cicekdal, Inge Bruggeman, Suzan Demuynck, Bahar Golabi, Elfride De Baere, et al. 2024. “Evolutionary Origin of Hoxc13-Dependent Skin Appendages in Amphibians.” NATURE COMMUNICATIONS 15 (1). https://doi.org/10.1038/s41467-024-46373-x.
- Chicago author-date (all authors)
- Carron, Marjolein, Attila Placido Sachslehner, Münevver Burcu Cicekdal, Inge Bruggeman, Suzan Demuynck, Bahar Golabi, Elfride De Baere, Wim Declercq, Erwin Tschachler, Kris Vleminckx, and Leopold Eckhart. 2024. “Evolutionary Origin of Hoxc13-Dependent Skin Appendages in Amphibians.” NATURE COMMUNICATIONS 15 (1). doi:10.1038/s41467-024-46373-x.
- Vancouver
- 1.Carron M, Sachslehner AP, Cicekdal MB, Bruggeman I, Demuynck S, Golabi B, et al. Evolutionary origin of Hoxc13-dependent skin appendages in amphibians. NATURE COMMUNICATIONS. 2024;15(1).
- IEEE
- [1]M. Carron et al., “Evolutionary origin of Hoxc13-dependent skin appendages in amphibians,” NATURE COMMUNICATIONS, vol. 15, no. 1, 2024.
@article{01HTY9BTC9XVN1565PWAGWS44F,
abstract = {{Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of special intermediate filament proteins, known as hair keratins, which are expressed under the control of the transcription factor Hoxc13. Here, we show that the cornified claws of Xenopus frogs contain homologs of hair keratins and the genes encoding these keratins are flanked by promoters in which binding sites of Hoxc13 are conserved. Furthermore, these keratins and Hoxc13 are co-expressed in the claw-forming epithelium of frog toe tips. Upon deletion of hoxc13, the expression of hair keratin homologs is abolished and the development of cornified claws is abrogated in X. tropicalis. These results indicate that Hoxc13-dependent expression of hair keratin homologs evolved already in stem tetrapods, presumably as a mechanism for protecting toe tips, and that this ancestral genetic program was coopted to the growth of hair in mammals.}},
articleno = {{2328}},
author = {{Carron, Marjolein and Sachslehner, Attila Placido and Cicekdal, Münevver Burcu and Bruggeman, Inge and Demuynck, Suzan and Golabi, Bahar and De Baere, Elfride and Declercq, Wim and Tschachler, Erwin and Vleminckx, Kris and Eckhart, Leopold}},
issn = {{2041-1723}},
journal = {{NATURE COMMUNICATIONS}},
keywords = {{BEST-FIT MODELS,PURE HAIR,HOXC13,EXPRESSION,GENES,DIVERSIFICATION,SELECTION,PROTEINS,PROTTEST,KERATINS}},
language = {{eng}},
number = {{1}},
pages = {{12}},
title = {{Evolutionary origin of Hoxc13-dependent skin appendages in amphibians}},
url = {{http://doi.org/10.1038/s41467-024-46373-x}},
volume = {{15}},
year = {{2024}},
}
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