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Mechanistic insights into DNA damage recognition and checkpoint control in plants

Josephine Herbst (UGent) , Qian-Qian Li (UGent) and Lieven De Veylder (UGent)
(2024) NATURE PLANTS. 10(4). p.539-550
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Abstract
The plant DNA damage response (DDR) pathway safeguards genomic integrity by rapid recognition and repair of DNA lesions that, if unrepaired, may cause genome instability. Most frequently, DNA repair goes hand in hand with a transient cell cycle arrest, which allows cells to repair the DNA lesions before engaging in a mitotic event, but consequently also affects plant growth and yield. Through the identification of DDR proteins and cell cycle regulators that react to DNA double-strand breaks or replication defects, it has become clear that these proteins and regulators form highly interconnected networks. These networks operate at both the transcriptional and post-transcriptional levels and include liquid-liquid phase separation and epigenetic mechanisms. Strikingly, whereas the upstream DDR sensors and signalling components are well conserved across eukaryotes, some of the more downstream effectors are diverged in plants, probably to suit unique lifestyle features. Additionally, DDR components display functional diversity across ancient plant species, dicots and monocots. The observed resistance of DDR mutants towards aluminium toxicity, phosphate limitation and seed ageing indicates that gaining knowledge about the plant DDR may offer solutions to combat the effects of climate change and the associated risk for food security.
Keywords
Plant Science, CELL-CYCLE CHECKPOINT, DOUBLE-STRAND BREAKS, ARABIDOPSIS-THALIANA, HOMOLOGOUS RECOMBINATION, STRUCTURAL MAINTENANCE, GENOME STABILITY, ROOT-GROWTH, REPLICATION, PROTEIN, KINASE

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Citation

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MLA
Herbst, Josephine, et al. “Mechanistic Insights into DNA Damage Recognition and Checkpoint Control in Plants.” NATURE PLANTS, vol. 10, no. 4, 2024, pp. 539–50, doi:10.1038/s41477-024-01652-9.
APA
Herbst, J., Li, Q.-Q., & De Veylder, L. (2024). Mechanistic insights into DNA damage recognition and checkpoint control in plants. NATURE PLANTS, 10(4), 539–550. https://doi.org/10.1038/s41477-024-01652-9
Chicago author-date
Herbst, Josephine, Qian-Qian Li, and Lieven De Veylder. 2024. “Mechanistic Insights into DNA Damage Recognition and Checkpoint Control in Plants.” NATURE PLANTS 10 (4): 539–50. https://doi.org/10.1038/s41477-024-01652-9.
Chicago author-date (all authors)
Herbst, Josephine, Qian-Qian Li, and Lieven De Veylder. 2024. “Mechanistic Insights into DNA Damage Recognition and Checkpoint Control in Plants.” NATURE PLANTS 10 (4): 539–550. doi:10.1038/s41477-024-01652-9.
Vancouver
1.
Herbst J, Li Q-Q, De Veylder L. Mechanistic insights into DNA damage recognition and checkpoint control in plants. NATURE PLANTS. 2024;10(4):539–50.
IEEE
[1]
J. Herbst, Q.-Q. Li, and L. De Veylder, “Mechanistic insights into DNA damage recognition and checkpoint control in plants,” NATURE PLANTS, vol. 10, no. 4, pp. 539–550, 2024.
@article{01HTPR7XEKPP68N7H9VXYYSMHF,
  abstract     = {{The plant DNA damage response (DDR) pathway safeguards genomic integrity by rapid recognition and repair of DNA lesions that, if unrepaired, may cause genome instability. Most frequently, DNA repair goes hand in hand with a transient cell cycle arrest, which allows cells to repair the DNA lesions before engaging in a mitotic event, but consequently also affects plant growth and yield. Through the identification of DDR proteins and cell cycle regulators that react to DNA double-strand breaks or replication defects, it has become clear that these proteins and regulators form highly interconnected networks. These networks operate at both the transcriptional and post-transcriptional levels and include liquid-liquid phase separation and epigenetic mechanisms. Strikingly, whereas the upstream DDR sensors and signalling components are well conserved across eukaryotes, some of the more downstream effectors are diverged in plants, probably to suit unique lifestyle features. Additionally, DDR components display functional diversity across ancient plant species, dicots and monocots. The observed resistance of DDR mutants towards aluminium toxicity, phosphate limitation and seed ageing indicates that gaining knowledge about the plant DDR may offer solutions to combat the effects of climate change and the associated risk for food security.}},
  author       = {{Herbst, Josephine and Li, Qian-Qian and De Veylder, Lieven}},
  issn         = {{2055-026X}},
  journal      = {{NATURE PLANTS}},
  keywords     = {{Plant Science,CELL-CYCLE CHECKPOINT,DOUBLE-STRAND BREAKS,ARABIDOPSIS-THALIANA,HOMOLOGOUS RECOMBINATION,STRUCTURAL MAINTENANCE,GENOME STABILITY,ROOT-GROWTH,REPLICATION,PROTEIN,KINASE}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{539--550}},
  title        = {{Mechanistic insights into DNA damage recognition and checkpoint control in plants}},
  url          = {{http://doi.org/10.1038/s41477-024-01652-9}},
  volume       = {{10}},
  year         = {{2024}},
}
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