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Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees

Regis Lefebre (UGent) , Bart Broeckx (UGent) , Lina De Smet (UGent) , Luc Peelman (UGent) and Dirk de Graaf (UGent)
(2024) SCIENTIFIC REPORTS. 14(1).
Author
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Abstract
In 2019, a joint eight-variant model was published in which eight single nucleotide polymorphisms (SNPs) in seven Apis mellifera genes were associated with Varroa destructor drone brood resistance (DBR, i.e. mite non-reproduction in drone brood). As this model was derived from only one Darwinian Black Bee Box colony, it could not directly be applied on a population-overarching scale in the northern part of Belgium (Flanders), where beekeepers prefer the carnica subspecies. To determine whether these eight SNPs remained associated with the DBR trait on a Flemish colony-broad scope, we performed population-wide modelling through sampling of various A. mellifera carnica colonies, DBR scoring of Varroa-infested drone brood and variant genotyping. Novel eight-variant modelling was performed and the classification performance of the eight SNPs was evaluated. Besides, we built a reduced three-variant model retaining only three genetic variants and found that this model classified 76% of the phenotyped drones correctly. To examine the spread of beneficial alleles and predict the DBR probability distribution in Flanders, we determined the allelic frequencies of the three variants in 292 A. mellifera carnica queens. As such, this research reveals prospects of marker-assisted selection for Varroa drone brood resistance in honeybees.
Keywords
Multidisciplinary, VARROA-JACOBSONI OUD, DRONE BROOD CELLS, MITOCHONDRIAL-DNA VARIATION, APIS-MELLIFERA-IBERIENSIS, WORKER BROOD, REPRODUCTIVE ABILITY, DEFENSE BEHAVIOR, DESTRUCTOR, TOLERANCE, INFESTATION

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Citation

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MLA
Lefebre, Regis, et al. “Population-Wide Modelling Reveals Prospects of Marker-Assisted Selection for Parasitic Mite Resistance in Honey Bees.” SCIENTIFIC REPORTS, vol. 14, no. 1, 2024, doi:10.1038/s41598-024-58596-5.
APA
Lefebre, R., Broeckx, B., De Smet, L., Peelman, L., & de Graaf, D. (2024). Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees. SCIENTIFIC REPORTS, 14(1). https://doi.org/10.1038/s41598-024-58596-5
Chicago author-date
Lefebre, Regis, Bart Broeckx, Lina De Smet, Luc Peelman, and Dirk de Graaf. 2024. “Population-Wide Modelling Reveals Prospects of Marker-Assisted Selection for Parasitic Mite Resistance in Honey Bees.” SCIENTIFIC REPORTS 14 (1). https://doi.org/10.1038/s41598-024-58596-5.
Chicago author-date (all authors)
Lefebre, Regis, Bart Broeckx, Lina De Smet, Luc Peelman, and Dirk de Graaf. 2024. “Population-Wide Modelling Reveals Prospects of Marker-Assisted Selection for Parasitic Mite Resistance in Honey Bees.” SCIENTIFIC REPORTS 14 (1). doi:10.1038/s41598-024-58596-5.
Vancouver
1.
Lefebre R, Broeckx B, De Smet L, Peelman L, de Graaf D. Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees. SCIENTIFIC REPORTS. 2024;14(1).
IEEE
[1]
R. Lefebre, B. Broeckx, L. De Smet, L. Peelman, and D. de Graaf, “Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees,” SCIENTIFIC REPORTS, vol. 14, no. 1, 2024.
@article{01HTM3G3TFA3ZD386EWVPPQ14R,
  abstract     = {{In 2019, a joint eight-variant model was published in which eight single nucleotide polymorphisms (SNPs) in seven Apis mellifera genes were associated with Varroa destructor drone brood resistance (DBR, i.e. mite non-reproduction in drone brood). As this model was derived from only one Darwinian Black Bee Box colony, it could not directly be applied on a population-overarching scale in the northern part of Belgium (Flanders), where beekeepers prefer the carnica subspecies. To determine whether these eight SNPs remained associated with the DBR trait on a Flemish colony-broad scope, we performed population-wide modelling through sampling of various A. mellifera carnica colonies, DBR scoring of Varroa-infested drone brood and variant genotyping. Novel eight-variant modelling was performed and the classification performance of the eight SNPs was evaluated. Besides, we built a reduced three-variant model retaining only three genetic variants and found that this model classified 76% of the phenotyped drones correctly. To examine the spread of beneficial alleles and predict the DBR probability distribution in Flanders, we determined the allelic frequencies of the three variants in 292 A. mellifera carnica queens. As such, this research reveals prospects of marker-assisted selection for Varroa drone brood resistance in honeybees.}},
  articleno    = {{7866}},
  author       = {{Lefebre, Regis and Broeckx, Bart and De Smet, Lina and Peelman, Luc and de Graaf, Dirk}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Multidisciplinary,VARROA-JACOBSONI OUD,DRONE BROOD CELLS,MITOCHONDRIAL-DNA VARIATION,APIS-MELLIFERA-IBERIENSIS,WORKER BROOD,REPRODUCTIVE ABILITY,DEFENSE BEHAVIOR,DESTRUCTOR,TOLERANCE,INFESTATION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{13}},
  title        = {{Population-wide modelling reveals prospects of marker-assisted selection for parasitic mite resistance in honey bees}},
  url          = {{http://doi.org/10.1038/s41598-024-58596-5}},
  volume       = {{14}},
  year         = {{2024}},
}
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