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Compact sub-nanosecond time-gated camera based on a new 128x128 Current-Assisted Photonic Sampler (CAPS) for pre-clinical macroscale fluorescence lifetime imaging

Thomas Van den Dries, Thomas Lapauw, Simone Janssen (UGent) , Sevada Sahakian, Maarten Kuijk and Hans Ingelberts
(2024) Silicon Photonics XIX. In Proceedings of SPIE 12891.
Author
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Abstract
Time-gated image sensors with (sub-) nanosecond gating times enable applications in multiple domains. Commercial Intensified CCD cameras or the more recent time-gated SPAD image sensors suffer from low Quantum Efficiency. We present an imaging system based on the tauCAM, a compact time-gated camera with our new 128x128-pixel CAPS sensor. The higher resolution is achieved with a new pixel architecture, yielding an improved fill factor. The capabilities of the new imaging system are demonstrated in a pre-clinical experimental setup. In vivo imaging in subcutaneous mice tumor models reveal that FLT imaging with the tauCAM provides additional contrast between tumor and healthy tissue, in particular for tracers sensitive to their physiological environment.

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MLA
Van den Dries, Thomas, et al. “Compact Sub-Nanosecond Time-Gated Camera Based on a New 128x128 Current-Assisted Photonic Sampler (CAPS) for Pre-Clinical Macroscale Fluorescence Lifetime Imaging.” Silicon Photonics XIX, edited by Graham T. Reed and Andrew P. Knights, vol. 12891, SPIE, 2024, doi:10.1117/12.3001047.5e7c8897-be24-ee11-a999-00505691c5e1.
APA
Van den Dries, T., Lapauw, T., Janssen, S., Sahakian, S., Kuijk, M., & Ingelberts, H. (2024). Compact sub-nanosecond time-gated camera based on a new 128x128 Current-Assisted Photonic Sampler (CAPS) for pre-clinical macroscale fluorescence lifetime imaging. In G. T. Reed & A. P. Knights (Eds.), Silicon Photonics XIX (Vol. 12891). https://doi.org/10.1117/12.3001047.5e7c8897-be24-ee11-a999-00505691c5e1
Chicago author-date
Van den Dries, Thomas, Thomas Lapauw, Simone Janssen, Sevada Sahakian, Maarten Kuijk, and Hans Ingelberts. 2024. “Compact Sub-Nanosecond Time-Gated Camera Based on a New 128x128 Current-Assisted Photonic Sampler (CAPS) for Pre-Clinical Macroscale Fluorescence Lifetime Imaging.” In Silicon Photonics XIX, edited by Graham T. Reed and Andrew P. Knights. Vol. 12891. SPIE. https://doi.org/10.1117/12.3001047.5e7c8897-be24-ee11-a999-00505691c5e1.
Chicago author-date (all authors)
Van den Dries, Thomas, Thomas Lapauw, Simone Janssen, Sevada Sahakian, Maarten Kuijk, and Hans Ingelberts. 2024. “Compact Sub-Nanosecond Time-Gated Camera Based on a New 128x128 Current-Assisted Photonic Sampler (CAPS) for Pre-Clinical Macroscale Fluorescence Lifetime Imaging.” In Silicon Photonics XIX, ed by. Graham T. Reed and Andrew P. Knights. Vol. 12891. SPIE. doi:10.1117/12.3001047.5e7c8897-be24-ee11-a999-00505691c5e1.
Vancouver
1.
Van den Dries T, Lapauw T, Janssen S, Sahakian S, Kuijk M, Ingelberts H. Compact sub-nanosecond time-gated camera based on a new 128x128 Current-Assisted Photonic Sampler (CAPS) for pre-clinical macroscale fluorescence lifetime imaging. In: Reed GT, Knights AP, editors. Silicon Photonics XIX. SPIE; 2024.
IEEE
[1]
T. Van den Dries, T. Lapauw, S. Janssen, S. Sahakian, M. Kuijk, and H. Ingelberts, “Compact sub-nanosecond time-gated camera based on a new 128x128 Current-Assisted Photonic Sampler (CAPS) for pre-clinical macroscale fluorescence lifetime imaging,” in Silicon Photonics XIX, San Francisco, California, United States, 2024, vol. 12891.
@inproceedings{01HTDNZRVCZ7X21HMQR0SZT28W,
  abstract     = {{Time-gated image sensors with (sub-) nanosecond gating times enable applications in multiple domains. Commercial Intensified CCD cameras or the more recent time-gated SPAD image sensors suffer from low Quantum Efficiency. We present an imaging system based on the tauCAM, a compact time-gated camera with our new 128x128-pixel CAPS sensor. The higher resolution is achieved with a new pixel architecture, yielding an improved fill factor. The capabilities of the new imaging system are demonstrated in a pre-clinical experimental setup. In vivo imaging in subcutaneous mice tumor models reveal that FLT imaging with the tauCAM provides additional contrast between tumor and healthy tissue, in particular for tracers sensitive to their physiological environment.}},
  articleno    = {{PC128910G}},
  author       = {{Van den Dries, Thomas and Lapauw, Thomas and Janssen, Simone and Sahakian, Sevada and Kuijk, Maarten and Ingelberts, Hans}},
  booktitle    = {{Silicon Photonics XIX}},
  editor       = {{Reed, Graham T. and Knights, Andrew P.}},
  issn         = {{0277-786X}},
  language     = {{eng}},
  location     = {{San Francisco, California, United States}},
  pages        = {{1}},
  publisher    = {{SPIE}},
  title        = {{Compact sub-nanosecond time-gated camera based on a new 128x128 Current-Assisted Photonic Sampler (CAPS) for pre-clinical macroscale fluorescence lifetime imaging}},
  url          = {{http://doi.org/10.1117/12.3001047.5e7c8897-be24-ee11-a999-00505691c5e1}},
  volume       = {{12891}},
  year         = {{2024}},
}
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