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Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond

Marthe Vandevelde (UGent) , Andreas Simoens (UGent) , Bavo Vandekerckhove (UGent) and Christian Stevens (UGent)
(2024) RSC MEDICINAL CHEMISTRY. 15(3). p.998-1002
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Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT2AR and 5-HT2BR and one compound showed a higher selectivity towards 5-HT2AR than psilocin. Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor.
Keywords
DISCOVERY, DRUG

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Citation

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MLA
Vandevelde, Marthe, et al. “Synthesis and Bioactivity of Psilocybin Analogues Containing a Stable Carbon-Phosphorus Bond.” RSC MEDICINAL CHEMISTRY, vol. 15, no. 3, 2024, pp. 998–1002, doi:10.1039/d4md00043a.
APA
Vandevelde, M., Simoens, A., Vandekerckhove, B., & Stevens, C. (2024). Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond. RSC MEDICINAL CHEMISTRY, 15(3), 998–1002. https://doi.org/10.1039/d4md00043a
Chicago author-date
Vandevelde, Marthe, Andreas Simoens, Bavo Vandekerckhove, and Christian Stevens. 2024. “Synthesis and Bioactivity of Psilocybin Analogues Containing a Stable Carbon-Phosphorus Bond.” RSC MEDICINAL CHEMISTRY 15 (3): 998–1002. https://doi.org/10.1039/d4md00043a.
Chicago author-date (all authors)
Vandevelde, Marthe, Andreas Simoens, Bavo Vandekerckhove, and Christian Stevens. 2024. “Synthesis and Bioactivity of Psilocybin Analogues Containing a Stable Carbon-Phosphorus Bond.” RSC MEDICINAL CHEMISTRY 15 (3): 998–1002. doi:10.1039/d4md00043a.
Vancouver
1.
Vandevelde M, Simoens A, Vandekerckhove B, Stevens C. Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond. RSC MEDICINAL CHEMISTRY. 2024;15(3):998–1002.
IEEE
[1]
M. Vandevelde, A. Simoens, B. Vandekerckhove, and C. Stevens, “Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond,” RSC MEDICINAL CHEMISTRY, vol. 15, no. 3, pp. 998–1002, 2024.
@article{01HT56905BE7WH75WQE7DDW4E3,
  abstract     = {{Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT2AR and 5-HT2BR and one compound showed a higher selectivity towards 5-HT2AR than psilocin.

 Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor.}},
  author       = {{Vandevelde, Marthe and Simoens, Andreas and Vandekerckhove, Bavo and Stevens, Christian}},
  issn         = {{2632-8682}},
  journal      = {{RSC MEDICINAL CHEMISTRY}},
  keywords     = {{DISCOVERY,DRUG}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{998--1002}},
  title        = {{Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond}},
  url          = {{http://doi.org/10.1039/d4md00043a}},
  volume       = {{15}},
  year         = {{2024}},
}
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