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Performance of MRI for detection of ≥pT1b disease in local staging of endometrial cancer

Leonie Van Vynckt, Philippe Tummers (UGent) , Hannelore Denys (UGent) , Menekse GOKER (UGent) , Sifrid Hendrickx (UGent) , Eline Naert (UGent) , Rawand Salihi (UGent) , Koen Van de Vijver (UGent) , Gabriëlle van Ramshorst (UGent) , Donatienne Van Weehaeghe (UGent) , et al.
(2024) CANCERS. 16(6).
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Abstract
Simple Summary Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The purpose of this study was to assess the performance of MRI for the detection of >= pT1b disease (i.e., tumor invasion in >= 50% of the myometrium, into the cervical stroma or spread outside the uterus) and to evaluate whether tumor size measured via MRI was predictive for >= pT1b disease, independent of imaging signs of invasion. We found that MRI had good performance for the detection of >= pT1b disease and that a tumor diameter of >= 40 mm and a tumor volume of >= 20 mL were highly predictive for the presence of >= pT1b disease. Our results support the use of MRI in the preoperative staging of EC and suggest including size criteria in EC staging guidelines.Abstract Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The presence of >= pT1b disease (i.e., tumor invasion in >= 50% of the myometrium, into the cervical stroma or spread outside the uterus) has important prognostic value and implications for the decision to perform lymphadenectomy. The purpose of this study was to assess the performance of MRI for the detection of >= pT1b disease and to evaluate whether tumor size measured via MRI was predictive for >= pT1b disease, independent of imaging signs of deep invasion. MRI T-staging and tumor diameter and volume were correlated with histopathology of the hysterectomy specimen in 126 patients. MRI had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 70.0%, 83.3%, 79.2%, 75.3% and 77.0%, respectively, for the detection of >= pT1b disease. A tumor diameter of >= 40 mm and volume of >= 20 mL measured via MRI were predictive for >= pT1b disease at rates of 78.3% and 87.1%, respectively. An EC size of at least 5 mm upon MRI was predictive for >= pT1b disease in more than 50% of cases. Our results support the use of MRI in the preoperative staging of EC and suggest including size criteria in EC staging guidelines.
Keywords
Cancer Research, Oncology, staging, MRI, magnetic resonance imaging, endometrial cancer

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MLA
Van Vynckt, Leonie, et al. “Performance of MRI for Detection of ≥pT1b Disease in Local Staging of Endometrial Cancer.” CANCERS, vol. 16, no. 6, 2024, doi:10.3390/cancers16061142.
APA
Van Vynckt, L., Tummers, P., Denys, H., GOKER, M., Hendrickx, S., Naert, E., … De Visschere, P. (2024). Performance of MRI for detection of ≥pT1b disease in local staging of endometrial cancer. CANCERS, 16(6). https://doi.org/10.3390/cancers16061142
Chicago author-date
Van Vynckt, Leonie, Philippe Tummers, Hannelore Denys, Menekse GOKER, Sifrid Hendrickx, Eline Naert, Rawand Salihi, et al. 2024. “Performance of MRI for Detection of ≥pT1b Disease in Local Staging of Endometrial Cancer.” CANCERS 16 (6). https://doi.org/10.3390/cancers16061142.
Chicago author-date (all authors)
Van Vynckt, Leonie, Philippe Tummers, Hannelore Denys, Menekse GOKER, Sifrid Hendrickx, Eline Naert, Rawand Salihi, Koen Van de Vijver, Gabriëlle van Ramshorst, Donatienne Van Weehaeghe, Katrien Vandecasteele, Geert Villeirs, and Pieter De Visschere. 2024. “Performance of MRI for Detection of ≥pT1b Disease in Local Staging of Endometrial Cancer.” CANCERS 16 (6). doi:10.3390/cancers16061142.
Vancouver
1.
Van Vynckt L, Tummers P, Denys H, GOKER M, Hendrickx S, Naert E, et al. Performance of MRI for detection of ≥pT1b disease in local staging of endometrial cancer. CANCERS. 2024;16(6).
IEEE
[1]
L. Van Vynckt et al., “Performance of MRI for detection of ≥pT1b disease in local staging of endometrial cancer,” CANCERS, vol. 16, no. 6, 2024.
@article{01HT2QZ9Z3760JG3J8P0VR9V9H,
  abstract     = {{Simple Summary Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The purpose of this study was to assess the performance of MRI for the detection of >= pT1b disease (i.e., tumor invasion in >= 50% of the myometrium, into the cervical stroma or spread outside the uterus) and to evaluate whether tumor size measured via MRI was predictive for >= pT1b disease, independent of imaging signs of invasion. We found that MRI had good performance for the detection of >= pT1b disease and that a tumor diameter of >= 40 mm and a tumor volume of >= 20 mL were highly predictive for the presence of >= pT1b disease. Our results support the use of MRI in the preoperative staging of EC and suggest including size criteria in EC staging guidelines.Abstract Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The presence of >= pT1b disease (i.e., tumor invasion in >= 50% of the myometrium, into the cervical stroma or spread outside the uterus) has important prognostic value and implications for the decision to perform lymphadenectomy. The purpose of this study was to assess the performance of MRI for the detection of >= pT1b disease and to evaluate whether tumor size measured via MRI was predictive for >= pT1b disease, independent of imaging signs of deep invasion. MRI T-staging and tumor diameter and volume were correlated with histopathology of the hysterectomy specimen in 126 patients. MRI had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 70.0%, 83.3%, 79.2%, 75.3% and 77.0%, respectively, for the detection of >= pT1b disease. A tumor diameter of >= 40 mm and volume of >= 20 mL measured via MRI were predictive for >= pT1b disease at rates of 78.3% and 87.1%, respectively. An EC size of at least 5 mm upon MRI was predictive for >= pT1b disease in more than 50% of cases. Our results support the use of MRI in the preoperative staging of EC and suggest including size criteria in EC staging guidelines.}},
  articleno    = {{1142}},
  author       = {{Van Vynckt, Leonie and Tummers, Philippe and Denys, Hannelore and GOKER, Menekse and Hendrickx, Sifrid and Naert, Eline and Salihi, Rawand and Van de Vijver, Koen and van Ramshorst, Gabriëlle and Van Weehaeghe, Donatienne and Vandecasteele, Katrien and Villeirs, Geert and De Visschere, Pieter}},
  issn         = {{2072-6694}},
  journal      = {{CANCERS}},
  keywords     = {{Cancer Research,Oncology,staging,MRI,magnetic resonance imaging,endometrial cancer}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{13}},
  title        = {{Performance of MRI for detection of ≥pT1b disease in local staging of endometrial cancer}},
  url          = {{http://doi.org/10.3390/cancers16061142}},
  volume       = {{16}},
  year         = {{2024}},
}
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