Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 3.84 MB
Add to list
  1. Search results
  2. Streptococcal quorum sensing peptide ...

Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting

Anton De Spiegeleer (UGent) , Amélie Descamps (UGent) , Evelien Wynendaele (UGent) , Petar Naumovski (UGent) , Liesbeth Crombez (UGent) , Marta Planas, Lidia Feliu, Daniel Knappe, Vincent Mouly, Anne Bigot, et al.
(2024) BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1870(4).
Author
Organization
Project
Abstract
Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms is currently limited, which has significantly hindered the development of targeted therapies. In this study, we explored the possibility that the streptococcal quorum sensing peptide Competence Stimulating Peptide 7 (CSP-7) might be a previously unidentified contributor to clinical muscle wasting. We found that CSP-7 selectively triggers muscle cell inflammation in vitro, specifically the release of IL-6. Furthermore, we demonstrated that CSP-7 can traverse the gastrointestinal barrier in vitro and is present in the systemic circulation in humans in vivo. Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights into the pathophysiology of muscle inflammation and wasting.
Keywords
Muscle wasting, CSP-7, Competence stimulating peptide, Quorum sensing peptide, Microbiota, Sarcopenia, LC-MS, Human plasma, Peptide, cachexia

Downloads

  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.84 MB

Citation

Please use this url to cite or link to this publication:

MLA
De Spiegeleer, Anton, et al. “Streptococcal Quorum Sensing Peptide CSP-7 Contributes to Muscle Inflammation and Wasting.” BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, vol. 1870, no. 4, 2024, doi:10.1016/j.bbadis.2024.167094.
APA
De Spiegeleer, A., Descamps, A., Wynendaele, E., Naumovski, P., Crombez, L., Planas, M., … De Spiegeleer, B. (2024). Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1870(4). https://doi.org/10.1016/j.bbadis.2024.167094
Chicago author-date
De Spiegeleer, Anton, Amélie Descamps, Evelien Wynendaele, Petar Naumovski, Liesbeth Crombez, Marta Planas, Lidia Feliu, et al. 2024. “Streptococcal Quorum Sensing Peptide CSP-7 Contributes to Muscle Inflammation and Wasting.” BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1870 (4). https://doi.org/10.1016/j.bbadis.2024.167094.
Chicago author-date (all authors)
De Spiegeleer, Anton, Amélie Descamps, Evelien Wynendaele, Petar Naumovski, Liesbeth Crombez, Marta Planas, Lidia Feliu, Daniel Knappe, Vincent Mouly, Anne Bigot, Rafael Bielza, Ralf Hoffmann, Nele Van Den Noortgate, Dirk Elewaut, and Bart De Spiegeleer. 2024. “Streptococcal Quorum Sensing Peptide CSP-7 Contributes to Muscle Inflammation and Wasting.” BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1870 (4). doi:10.1016/j.bbadis.2024.167094.
Vancouver
1.
De Spiegeleer A, Descamps A, Wynendaele E, Naumovski P, Crombez L, Planas M, et al. Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(4).
IEEE
[1]
A. De Spiegeleer et al., “Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting,” BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, vol. 1870, no. 4, 2024.
@article{01HS0MJ9VJ980MAD6TCJ93V6GA,
  abstract     = {{Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms is currently limited, which has significantly hindered the development of targeted therapies. In this study, we explored the possibility that the streptococcal quorum sensing peptide Competence Stimulating Peptide 7 (CSP-7) might be a previously unidentified contributor to clinical muscle wasting. We found that CSP-7 selectively triggers muscle cell inflammation in vitro, specifically the release of IL-6. Furthermore, we demonstrated that CSP-7 can traverse the gastrointestinal barrier in vitro and is present in the systemic circulation in humans in vivo. Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights into the pathophysiology of muscle inflammation and wasting.}},
  articleno    = {{167094}},
  author       = {{De Spiegeleer, Anton and Descamps, Amélie and Wynendaele, Evelien and Naumovski, Petar and Crombez, Liesbeth and Planas, Marta and Feliu, Lidia and Knappe, Daniel and Mouly, Vincent and Bigot, Anne and Bielza, Rafael and Hoffmann, Ralf and Van Den Noortgate, Nele and Elewaut, Dirk and De Spiegeleer, Bart}},
  issn         = {{0925-4439}},
  journal      = {{BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE}},
  keywords     = {{Muscle wasting,CSP-7,Competence stimulating peptide,Quorum sensing peptide,Microbiota,Sarcopenia,LC-MS,Human plasma,Peptide,cachexia}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{11}},
  title        = {{Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting}},
  url          = {{http://doi.org/10.1016/j.bbadis.2024.167094}},
  volume       = {{1870}},
  year         = {{2024}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: