@article{01HRRXMYRN8Z58WH3067QTZSP0,
  abstract     = {{Objective
Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.

Methods
In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.

Results
Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.

Conclusions
cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.

Significance
These findings highlight the importance of accounting for individual differences when examining TBS effects.}},
  author       = {{De Smet, Stefanie and Int-Veen, Isabell and Vanhollebeke, Gert and Pulópulos Tripiana, Matias Miguel and Barth, Beatrix and Pasche, Sarah and Baeken, Chris and Nuerk, Hans-Christoph and Plewnia, Christian and Nieratschker, Vanessa and Fallgatter, Andreas Jochen and Ehlis, Ann-Christine and Vanderhasselt, Marie-Anne and Rosenbaum, David}},
  issn         = {{1388-2457}},
  journal      = {{CLINICAL NEUROPHYSIOLOGY}},
  keywords     = {{Repetitive Transcranial Magnetic,Stimulation (rTMS),Theta Burst Stimulation (TBS),Prefrontal Cortex (PFC),Rumination,Trier Social Stress Test,Psychophysiology,Cortisol,TRANSCRANIAL MAGNETIC STIMULATION,DORSOLATERAL PREFRONTAL CORTEX,HF-RTMS SESSION,PERSEVERATIVE COGNITION,DEPRESSIVE RUMINATION,RESPONSES,ACTIVATION,SYMPTOMS,CORTISOL,VARIABILITY}},
  language     = {{eng}},
  pages        = {{235--247}},
  title        = {{Trait-dependent effects of theta burst stimulation after psychosocial stress : a sham-controlled study in healthy individuals}},
  url          = {{http://doi.org/10.1016/j.clinph.2024.03.016}},
  volume       = {{162}},
  year         = {{2024}},
}

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