@article{01HR9ZK815XYFGREH8JSWKB7TW,
  abstract     = {{Background Post-weaned piglets suffer from F18+Escherichia coli (E. coli) infections resulting in post-weaning diarrhoea or oedema disease. Frequently used management strategies, including colistin and zinc oxide, have contributed to the emergence and spread of antimicrobial resistance. Novel antimicrobials capable of directly interacting with pathogens and modulating the host immune responses are being investigated. Lactoferrin has shown promising results against porcine enterotoxigenic E. coli strains, both in vitro and in vivo. Results We investigated the influence of bovine lactoferrin (bLF) on the microbiome of healthy and infected weaned piglets. Additionally, we assessed whether bLF influenced the immune responses upon Shiga toxin-producing E. coli (STEC) infection. Therefore, 2 in vivo trials were conducted: a microbiome trial and a challenge infection trial, using an F18+ STEC strain. BLF did not affect the alpha- and beta-diversity. However, bLF groups showed a higher relative abundance (RA) for the Actinobacteria phylum and the Bifidobacterium genus in the ileal mucosa. When analysing the immune response upon infection, the STEC group exhibited a significant increase in F18-specific IgG serum levels, whereas this response was absent in the bLF group. Conclusion Taken together, the oral administration of bLF did not have a notable impact on the alpha- and beta-diversity of the gut microbiome in weaned piglets. Nevertheless, it did increase the RA of the Actinobacteria phylum and Bifidobacterium genus, which have previously been shown to play an important role in maintaining gut homeostasis. Furthermore, bLF administration during STEC infection resulted in the absence of F18-specific serum IgG responses.}},
  articleno    = {{39}},
  author       = {{Dierick, Matthias and Ongena, Ruben and Vanrompay, Daisy and Devriendt, Bert and Cox, Eric}},
  issn         = {{1674-9782}},
  journal      = {{JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY}},
  keywords     = {{E. coli,Immune modulation,Lactoferrin,Microbiome,ESCHERICHIA-COLI,RESISTANCE GENE,GROWTH-PERFORMANCE,TRANSGENIC MILK,EDEMA DISEASE,PURIFIED F4,PIGS,MUCOSAL,HOMEOSTASIS,CONSUMPTION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{14}},
  publisher    = {{BMC}},
  title        = {{Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin-producing E. coli challenged weaned piglets}},
  url          = {{http://doi.org/10.1186/s40104-023-00985-3}},
  volume       = {{15}},
  year         = {{2024}},
}

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