@article{01HR7G2FNBT9J1TSCB85NXFXJ5,
  abstract     = {{PurposeIntestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy. Curative treatment requires multidisciplinary approach, with surgical options consist of the endonasal endoscopic approach (EEA) and external surgery (EXTS). Here, we provide the post-operative and survival results from a single-center long-term follow-up.MethodsWe report long-term follow-up of 92 ITAC cases treated between 1998 and 2018, treated with EEA (n = 40) or EXTS (n = 52). Survival estimates, post-operative complications and duration of hospitalization were compared between surgical modalities.ResultsBaseline characteristics were similar. A higher number of T4b tumors (16%), and subsequently more tumoral invasion (39%), was present in patients undergoing EXTS compared to EEA (3% and 18%, respectively). No difference in Barnes histology subtypes was noticed. Patients undergoing EEA had a shorter post-operative hospitalization stay versus EXTS (4 versus 7 days). Use of EEA was associated to improved disease-specific survival (DSS; 11.4 versus 4.4 years; HREEA = 0.53), especially for patients with T3-4a tumors (11.4 versus 3.0 years; HREEA = 0.41). Patients with T3-4 stage, tumoral invasion, positive surgical margins, mucinous or mixed histology, and prolonged post-operative hospital stay showed poor local relapse-free, disease-free, overall, and DSS.ConclusionsLong-term follow-up in locally advanced ITAC demonstrates that resection by EEA is correlated with improved DSS compared to EXTS, especially for T3-4 tumors. No significant differences between both treatment modalities was observed regarding per- and post-operative complications, although hospitalization in patients undergoing EEA was shorter than for patients treated with EXTS. These results confirm that EEA should remain the preferred surgical procedure in operable cases of sinonasal ITAC.}},
  author       = {{Vermassen, Tijl and De Keukeleire, Stijn and Saerens, Michael and Heerwegh, Sylvester and Debacker, Jens and Huvenne, Wouter and Deron, Philippe and Creytens, David and Ferdinande, Liesbeth and Rottey, Sylvie and Bachert, Claus and Duprez, Fréderic and Van Zele, Thibaut}},
  issn         = {{0937-4477}},
  journal      = {{EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY}},
  keywords     = {{Surgery,Prognosis,Sinus carcinoma,Intestinal-type adenocarcinoma,PARANASAL SINUS TUMORS,SKULL BASE,CRANIOFACIAL RESECTION,ENDOSCOPIC SURGERY,MALIGNANT-TUMORS,NASAL,COMPLICATIONS,RADIOTHERAPY}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2993--3004}},
  title        = {{Choice of surgery in intestinal-type adenocarcinoma of the sinonasal tract : a long-term comparative study}},
  url          = {{http://doi.org/10.1007/s00405-024-08447-w}},
  volume       = {{281}},
  year         = {{2024}},
}

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