Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
2 files | 22.10 MB
Add to list
  1. Search results
  2. Supra-threshold envelope-following re...

Supra-threshold envelope-following responses in the ageing population : an early marker of sensorineural hearing damage

Sarah Verhulst (UGent) , Heleen Van Der Biest (UGent) , Sarineh Keshishzadeh, Hannah Keppler (UGent) and Ingeborg Dhooge (UGent)
(2023) JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA. In Journal of the Acoustical Society of America 153(3, Supplement). p.A50-A50
Author
Organization
Project
Abstract
Envelope-following-responses (EFRs) evoked by supra-threshold amplitude-modulated sounds are promising markers of age-related or ototoxic-induced cochlear synaptopathy (CS) in research animals. A direct translation of these findings to EFR-based CS-quantification in humans is complicated by possible combinations of CS, inner-, outer-hair-cell damage or central deficits that can also affect EFR markers. To work towards a sensitive CS-marker for use in humans, we focus on an EFR stimulus that—in computational model simulations—is maximally sensitive to CS and investigate how this marker declines in an ageing population with or without OHC damage. 108 subjects participated in this study and were divided into two groups: (i) an ageing group with normal audiograms (i.e., 4-kHz-thresholds <20 dB HL, n = 89, 18–65 years) and (ii) older adults with impaired audiograms (n = 19, 45–75 years). We collected 120-Hz modulated EFRs, along with extended high-frequency audiograms, distortion-product otoacoustic emissions, and speech-reception thresholds (Flemish Matrix test). We calculated the rate of decline of each metric with age and conclude that the EFR marker predicts sensorineural hearing damage approximately 10 years earlier than the standard clinical audiogram. Additional relationships between audiometric, speech-intelligibility, and EFR markers are discussed. [Work supported by ERC 678120 RobSpear and 899858 CochSyn.]
Keywords
Acoustics and Ultrasonics, Arts and Humanities (miscellaneous)

Downloads

  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 22.00 MB
  • Download
    ACUS 682a.pdf
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • PDF
    • |
    • 102.31 KB

Citation

Please use this url to cite or link to this publication:

MLA
Verhulst, Sarah, et al. “Supra-Threshold Envelope-Following Responses in the Ageing Population : An Early Marker of Sensorineural Hearing Damage.” JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, vol. 153, no. 3, Supplement, 2023, pp. A50–A50, doi:10.1121/10.0018124.
APA
Verhulst, S., Van Der Biest, H., Keshishzadeh, S., Keppler, H., & Dhooge, I. (2023). Supra-threshold envelope-following responses in the ageing population : an early marker of sensorineural hearing damage. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 153(3, Supplement), A50–A50. https://doi.org/10.1121/10.0018124
Chicago author-date
Verhulst, Sarah, Heleen Van Der Biest, Sarineh Keshishzadeh, Hannah Keppler, and Ingeborg Dhooge. 2023. “Supra-Threshold Envelope-Following Responses in the Ageing Population : An Early Marker of Sensorineural Hearing Damage.” In JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 153:A50–A50. https://doi.org/10.1121/10.0018124.
Chicago author-date (all authors)
Verhulst, Sarah, Heleen Van Der Biest, Sarineh Keshishzadeh, Hannah Keppler, and Ingeborg Dhooge. 2023. “Supra-Threshold Envelope-Following Responses in the Ageing Population : An Early Marker of Sensorineural Hearing Damage.” In JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 153:A50–A50. doi:10.1121/10.0018124.
Vancouver
1.
Verhulst S, Van Der Biest H, Keshishzadeh S, Keppler H, Dhooge I. Supra-threshold envelope-following responses in the ageing population : an early marker of sensorineural hearing damage. In: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA. 2023. p. A50–A50.
IEEE
[1]
S. Verhulst, H. Van Der Biest, S. Keshishzadeh, H. Keppler, and I. Dhooge, “Supra-threshold envelope-following responses in the ageing population : an early marker of sensorineural hearing damage,” in JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, Chicago, IL, USA, 2023, vol. 153, no. 3, Supplement, pp. A50–A50.
@inproceedings{01HQNEBKSGRPKX79C2NQJ0DWXP,
  abstract     = {{Envelope-following-responses (EFRs) evoked by supra-threshold amplitude-modulated sounds are promising markers of age-related or ototoxic-induced cochlear synaptopathy (CS) in research animals. A direct translation of these findings to EFR-based CS-quantification in humans is complicated by possible combinations of CS, inner-, outer-hair-cell damage or central deficits that can also affect EFR markers. To work towards a sensitive CS-marker for use in humans, we focus on an EFR stimulus that—in computational model simulations—is maximally sensitive to CS and investigate how this marker declines in an ageing population with or without OHC damage. 108 subjects participated in this study and were divided into two groups: (i) an ageing group with normal audiograms (i.e., 4-kHz-thresholds <20 dB HL, n = 89, 18–65 years) and (ii) older adults with impaired audiograms (n = 19, 45–75 years). We collected 120-Hz modulated EFRs, along with extended high-frequency audiograms, distortion-product otoacoustic emissions, and speech-reception thresholds (Flemish Matrix test). We calculated the rate of decline of each metric with age and conclude that the EFR marker predicts sensorineural hearing damage approximately 10 years earlier than the standard clinical audiogram. Additional relationships between audiometric, speech-intelligibility, and EFR markers are discussed. [Work supported by ERC 678120 RobSpear and 899858 CochSyn.]}},
  articleno    = {{1aPP20}},
  author       = {{Verhulst, Sarah and Van Der Biest, Heleen and Keshishzadeh, Sarineh and Keppler, Hannah and Dhooge, Ingeborg}},
  booktitle    = {{JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA}},
  issn         = {{0001-4966}},
  keywords     = {{Acoustics and Ultrasonics,Arts and Humanities (miscellaneous)}},
  language     = {{eng}},
  location     = {{Chicago, IL, USA}},
  number       = {{3, Supplement}},
  pages        = {{1aPP20:A50--1aPP20:A50}},
  title        = {{Supra-threshold envelope-following responses in the ageing population : an early marker of sensorineural hearing damage}},
  url          = {{http://doi.org/10.1121/10.0018124}},
  volume       = {{153}},
  year         = {{2023}},
}
Altmetric
View in Altmetric