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Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana

Linhao Xu, Shiwei Zheng, Katja Witzel, Eveline Van De Slijke (UGent) , Alexandra Baekelandt (UGent) , Evelien Mylle (UGent) , Daniël Van Damme (UGent) , Jinping Cheng, Geert De Jaeger (UGent) , Dirk Inzé (UGent) , et al.
(2024) NATURE COMMUNICATIONS. 15(1).
Author
Organization
Abstract
The nuclear matrix is a nuclear compartment that has diverse functions in chromatin regulation and transcription. However, how this structure influences epigenetic modifications and gene expression in plants is largely unknown. In this study, we show that a nuclear matrix binding protein, AHL22, together with the two transcriptional repressors FRS7 and FRS12, regulates hypocotyl elongation by suppressing the expression of a group of genes known as SMALL AUXIN UP RNAs (SAURs) in Arabidopsis thaliana. The transcriptional repression of SAURs depends on their attachment to the nuclear matrix. The AHL22 complex not only brings these SAURs, which contain matrix attachment regions (MARs), to the nuclear matrix, but it also recruits the histone deacetylase HDA15 to the SAUR loci. This leads to the removal of H3 acetylation at the SAUR loci and the suppression of hypocotyl elongation. Taken together, our results indicate that MAR-binding proteins act as a hub for chromatin and epigenetic regulators. Moreover, we present a mechanism by which nuclear matrix attachment to chromatin regulates histone modifications, transcription, and hypocotyl elongation.
Keywords
General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary, DNA-BINDING PROTEIN, AT-HOOK, PHYTOCHROME B4-NUMBER-3, GENE-EXPRESSION, REGIONS, GROWTH, IDENTIFICATION, TRANSCRIPTION, ARCHITECTURE, COMPLEX

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MLA
Xu, Linhao, et al. “Chromatin Attachment to the Nuclear Matrix Represses Hypocotyl Elongation in Arabidopsis Thaliana.” NATURE COMMUNICATIONS, vol. 15, no. 1, Springer Science and Business Media LLC, 2024, doi:10.1038/s41467-024-45577-5.
APA
Xu, L., Zheng, S., Witzel, K., Van De Slijke, E., Baekelandt, A., Mylle, E., … Jiang, H. (2024). Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana. NATURE COMMUNICATIONS, 15(1). https://doi.org/10.1038/s41467-024-45577-5
Chicago author-date
Xu, Linhao, Shiwei Zheng, Katja Witzel, Eveline Van De Slijke, Alexandra Baekelandt, Evelien Mylle, Daniël Van Damme, et al. 2024. “Chromatin Attachment to the Nuclear Matrix Represses Hypocotyl Elongation in Arabidopsis Thaliana.” NATURE COMMUNICATIONS 15 (1). https://doi.org/10.1038/s41467-024-45577-5.
Chicago author-date (all authors)
Xu, Linhao, Shiwei Zheng, Katja Witzel, Eveline Van De Slijke, Alexandra Baekelandt, Evelien Mylle, Daniël Van Damme, Jinping Cheng, Geert De Jaeger, Dirk Inzé, and Hua Jiang. 2024. “Chromatin Attachment to the Nuclear Matrix Represses Hypocotyl Elongation in Arabidopsis Thaliana.” NATURE COMMUNICATIONS 15 (1). doi:10.1038/s41467-024-45577-5.
Vancouver
1.
Xu L, Zheng S, Witzel K, Van De Slijke E, Baekelandt A, Mylle E, et al. Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana. NATURE COMMUNICATIONS. 2024;15(1).
IEEE
[1]
L. Xu et al., “Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana,” NATURE COMMUNICATIONS, vol. 15, no. 1, 2024.
@article{01HQMQXQQAJHDBSA0W79Y5MBG3,
  abstract     = {{The nuclear matrix is a nuclear compartment that has diverse functions in chromatin regulation and transcription. However, how this structure influences epigenetic modifications and gene expression in plants is largely unknown. In this study, we show that a nuclear matrix binding protein, AHL22, together with the two transcriptional repressors FRS7 and FRS12, regulates hypocotyl elongation by suppressing the expression of a group of genes known as SMALL AUXIN UP RNAs (SAURs) in Arabidopsis thaliana. The transcriptional repression of SAURs depends on their attachment to the nuclear matrix. The AHL22 complex not only brings these SAURs, which contain matrix attachment regions (MARs), to the nuclear matrix, but it also recruits the histone deacetylase HDA15 to the SAUR loci. This leads to the removal of H3 acetylation at the SAUR loci and the suppression of hypocotyl elongation. Taken together, our results indicate that MAR-binding proteins act as a hub for chromatin and epigenetic regulators. Moreover, we present a mechanism by which nuclear matrix attachment to chromatin regulates histone modifications, transcription, and hypocotyl elongation.}},
  articleno    = {{1286}},
  author       = {{Xu, Linhao and Zheng, Shiwei and Witzel, Katja and Van De Slijke, Eveline and Baekelandt, Alexandra and Mylle, Evelien and Van Damme, Daniël and Cheng, Jinping and De Jaeger, Geert and Inzé, Dirk and Jiang, Hua}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary,DNA-BINDING PROTEIN,AT-HOOK,PHYTOCHROME B4-NUMBER-3,GENE-EXPRESSION,REGIONS,GROWTH,IDENTIFICATION,TRANSCRIPTION,ARCHITECTURE,COMPLEX}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{16}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{Chromatin attachment to the nuclear matrix represses hypocotyl elongation in Arabidopsis thaliana}},
  url          = {{http://doi.org/10.1038/s41467-024-45577-5}},
  volume       = {{15}},
  year         = {{2024}},
}
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