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Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity

Bram Van Den Eeckhout (UGent) , Marlies Ballegeer (UGent) , Jozefien De Clercq (UGent) , Elianne Burg (UGent) , Xavier Saelens (UGent) , Linos Vandekerckhove (UGent) and Sarah Gerlo (UGent)
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Abstract
IL-1R integrates signals from IL-1 alpha and IL-1 beta, and it is widely expressed across tissues and immune cell types. While the expression pattern and function of IL-1R within the innate immune system is well studied, its role in adaptive immunity, particularly within the CD8 T cell compartment, remains underexplored. Here, we show that CD8 T cells dynamically upregulate IL-1R1 levels during priming by APCs, which correlates with their proliferation status and the acquisition of an effector phenotype. Notably, this IL-1 sensitivity persists in memory CD8 T cells of both mice and humans, influencing effector cytokine production upon TCR reactivation. Furthermore, our study highlights that antiviral effector and tissue-resident CD8 T cell responses against influenza A virus infection become impaired in the absence of IL-1 signaling. Altogether, these data support the exploitation of IL-1 activity in the context of T cell vaccination strategies and warrant consideration of the impact of clinical IL-1 inhibition on the rollout of T cell immunity.
Keywords
Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis, infection, influenza A virus, CD8 T cells, interleukin-1

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MLA
Van Den Eeckhout, Bram, et al. “Rethinking IL-1 Antagonism in Respiratory Viral Infections : A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, no. 21, MDPI AG, 2023, doi:10.3390/ijms242115770.
APA
Van Den Eeckhout, B., Ballegeer, M., De Clercq, J., Burg, E., Saelens, X., Vandekerckhove, L., & Gerlo, S. (2023). Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(21). https://doi.org/10.3390/ijms242115770
Chicago author-date
Van Den Eeckhout, Bram, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, and Sarah Gerlo. 2023. “Rethinking IL-1 Antagonism in Respiratory Viral Infections : A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 (21). https://doi.org/10.3390/ijms242115770.
Chicago author-date (all authors)
Van Den Eeckhout, Bram, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, and Sarah Gerlo. 2023. “Rethinking IL-1 Antagonism in Respiratory Viral Infections : A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 (21). doi:10.3390/ijms242115770.
Vancouver
1.
Van Den Eeckhout B, Ballegeer M, De Clercq J, Burg E, Saelens X, Vandekerckhove L, et al. Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(21).
IEEE
[1]
B. Van Den Eeckhout et al., “Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity,” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, no. 21, 2023.
@article{01HQJY4QDFYE834TBE00XVMSG6,
  abstract     = {{IL-1R integrates signals from IL-1 alpha and IL-1 beta, and it is widely expressed across tissues and immune cell types. While the expression pattern and function of IL-1R within the innate immune system is well studied, its role in adaptive immunity, particularly within the CD8 T cell compartment, remains underexplored. Here, we show that CD8 T cells dynamically upregulate IL-1R1 levels during priming by APCs, which correlates with their proliferation status and the acquisition of an effector phenotype. Notably, this IL-1 sensitivity persists in memory CD8 T cells of both mice and humans, influencing effector cytokine production upon TCR reactivation. Furthermore, our study highlights that antiviral effector and tissue-resident CD8 T cell responses against influenza A virus infection become impaired in the absence of IL-1 signaling. Altogether, these data support the exploitation of IL-1 activity in the context of T cell vaccination strategies and warrant consideration of the impact of clinical IL-1 inhibition on the rollout of T cell immunity.}},
  articleno    = {{15770}},
  author       = {{Van Den Eeckhout, Bram and Ballegeer, Marlies and De Clercq, Jozefien and Burg, Elianne and Saelens, Xavier and Vandekerckhove, Linos and Gerlo, Sarah}},
  issn         = {{1661-6596}},
  journal      = {{INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}},
  keywords     = {{Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis,infection,influenza A virus,CD8 T cells,interleukin-1}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{14}},
  publisher    = {{MDPI AG}},
  title        = {{Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity}},
  url          = {{http://doi.org/10.3390/ijms242115770}},
  volume       = {{24}},
  year         = {{2023}},
}

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