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Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair : a prospective, multicenter, single-arm study

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Abstract
Background Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the n-hexyl cyanoacrylate glue Ifabond (TM) for mesh fixation in laparoscopic inguinal hernia repair.Methods This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond (TM) (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh (R) SURG ST (Peters Surgical)/Biomesh (R) P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh (R) SURG LI (Peters Surgical)/Premium (R) Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.Results Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 +/- 10.04; p < 0.0001) and 12-month (3.83 +/- 11.26; p < 0.0001) follow-up compared with before surgery (26.96 +/- 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients' QoL increased from an EQ-5D-3L index score of 0.82 +/- 0.19 preoperatively to 0.90 +/- 0.15 at 5 weeks (p < 0.0001) and 0.92 +/- 0.15 at 12 months after surgery (p < 0.0001). The EQ-VAS general health scoring increased from 79.03 +/- 12.69 preoperatively to 84.31 +/- 9.97 at 5-week (p < 0.0001) and 84.16 +/- 14.48 at 12-month follow-up (p < 0.0001).Conclusions Ifabond (TM) (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients' QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.
Keywords
Surgery, Pain, Laparoscopy, Polypropylene mesh, n-hexyl cyanoacrylate glue fixation, Inguinal hernia repair

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MLA
Dams, Anne, et al. “Cyanoacrylate Mesh Fixation for Laparoscopic Inguinal Hernia Repair : A Prospective, Multicenter, Single-Arm Study.” SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, vol. 37, no. 12, Springer Science and Business Media LLC, 2023, pp. 9105–15, doi:10.1007/s00464-023-10439-6.
APA
Dams, A., Vankeirsbilck, J., Poelmans, S., Kerschaever, I., Borreman, P., Berwouts, L., … Van der Speeten, K. (2023). Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair : a prospective, multicenter, single-arm study. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 37(12), 9105–9115. https://doi.org/10.1007/s00464-023-10439-6
Chicago author-date
Dams, Anne, Joost Vankeirsbilck, Stephan Poelmans, Ivan Kerschaever, Philippe Borreman, Luc Berwouts, Wim De Mulder, et al. 2023. “Cyanoacrylate Mesh Fixation for Laparoscopic Inguinal Hernia Repair : A Prospective, Multicenter, Single-Arm Study.” SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 37 (12): 9105–15. https://doi.org/10.1007/s00464-023-10439-6.
Chicago author-date (all authors)
Dams, Anne, Joost Vankeirsbilck, Stephan Poelmans, Ivan Kerschaever, Philippe Borreman, Luc Berwouts, Wim De Mulder, Julien Colle, Anthony Beunis, Vicky Dhooghe, Nele Van De Winkel, Mathias Allaeys, Michael Ruyssers, Dorien Haesen, and Kurt Van der Speeten. 2023. “Cyanoacrylate Mesh Fixation for Laparoscopic Inguinal Hernia Repair : A Prospective, Multicenter, Single-Arm Study.” SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 37 (12): 9105–9115. doi:10.1007/s00464-023-10439-6.
Vancouver
1.
Dams A, Vankeirsbilck J, Poelmans S, Kerschaever I, Borreman P, Berwouts L, et al. Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair : a prospective, multicenter, single-arm study. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES. 2023;37(12):9105–15.
IEEE
[1]
A. Dams et al., “Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair : a prospective, multicenter, single-arm study,” SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, vol. 37, no. 12, pp. 9105–9115, 2023.
@article{01HQBBC55H5MQJMRY9QK8658CT,
  abstract     = {{Background Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the n-hexyl cyanoacrylate glue Ifabond (TM) for mesh fixation in laparoscopic inguinal hernia repair.Methods This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond (TM) (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh (R) SURG ST (Peters Surgical)/Biomesh (R) P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh (R) SURG LI (Peters Surgical)/Premium (R) Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.Results Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 +/- 10.04; p < 0.0001) and 12-month (3.83 +/- 11.26; p < 0.0001) follow-up compared with before surgery (26.96 +/- 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients' QoL increased from an EQ-5D-3L index score of 0.82 +/- 0.19 preoperatively to 0.90 +/- 0.15 at 5 weeks (p < 0.0001) and 0.92 +/- 0.15 at 12 months after surgery (p < 0.0001). The EQ-VAS general health scoring increased from 79.03 +/- 12.69 preoperatively to 84.31 +/- 9.97 at 5-week (p < 0.0001) and 84.16 +/- 14.48 at 12-month follow-up (p < 0.0001).Conclusions Ifabond (TM) (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients' QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.}},
  author       = {{Dams, Anne and Vankeirsbilck, Joost and Poelmans, Stephan and Kerschaever, Ivan and Borreman, Philippe and Berwouts, Luc and De Mulder, Wim and Colle, Julien and Beunis, Anthony and Dhooghe, Vicky and Van De Winkel, Nele and Allaeys, Mathias and Ruyssers, Michael and Haesen, Dorien and Van der Speeten, Kurt}},
  issn         = {{0930-2794}},
  journal      = {{SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES}},
  keywords     = {{Surgery,Pain,Laparoscopy,Polypropylene mesh,n-hexyl cyanoacrylate glue fixation,Inguinal hernia repair}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{9105--9115}},
  publisher    = {{Springer Science and Business Media LLC}},
  title        = {{Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair : a prospective, multicenter, single-arm study}},
  url          = {{http://doi.org/10.1007/s00464-023-10439-6}},
  volume       = {{37}},
  year         = {{2023}},
}

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