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Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre

Reile Janssen, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck, Sunita Janssenswillen, Bram Slechten, Jannes Bode, Elke Wollants, Kristel Van Laethem, et al.
(2024) VIROLOGY JOURNAL. 21(1).
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Abstract
Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre (NRC) for respiratory pathogens, to be the first Belgian laboratory to develop and implement laboratory developed diagnostic assays for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and later to assess the quality of commercial kits. To meet the growing demand for decentralised testing, both clinical laboratories and government-supported high-throughput platforms were gradually deployed across Belgium. Consequently, the role of the NRC transitioned from a specialised testing laboratory to strengthening capacity and coordinating quality assurance. Here, we outline the measures taken by the NRC, the national public health institute Sciensano and the executing clinical laboratories to ensure effective quality management of molecular testing throughout the initial two years of the pandemic (March 2020 to March 2022).
Keywords
National reference centre, High-throughput testing, Quality assurance, elgium, COVID-19, SARS-CoV-2

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MLA
Janssen, Reile, et al. “Nationwide Quality Assurance of High-Throughput Diagnostic Molecular Testing during the SARS-CoV-2 Pandemic : Role of the Belgian National Reference Centre.” VIROLOGY JOURNAL, vol. 21, no. 1, 2024, doi:10.1186/s12985-024-02308-y.
APA
Janssen, R., Cuypers, L., Laenen, L., Keyaerts, E., Beuselinck, K., Janssenswillen, S., … Genomics Belgium Consortium, C.-19. (2024). Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre. VIROLOGY JOURNAL, 21(1). https://doi.org/10.1186/s12985-024-02308-y
Chicago author-date
Janssen, Reile, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck, Sunita Janssenswillen, Bram Slechten, et al. 2024. “Nationwide Quality Assurance of High-Throughput Diagnostic Molecular Testing during the SARS-CoV-2 Pandemic : Role of the Belgian National Reference Centre.” VIROLOGY JOURNAL 21 (1). https://doi.org/10.1186/s12985-024-02308-y.
Chicago author-date (all authors)
Janssen, Reile, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck, Sunita Janssenswillen, Bram Slechten, Jannes Bode, Elke Wollants, Kristel Van Laethem, Annabel Rector, Mandy Bloemen, Anke Sijmons, Nathalie de Schaetzen, Arnaud Capron, Kurt Van Baelen, Thierry Pascal, Celine Vermeiren, Fabrice Bureau, Jo Vandesompele, Pieter De Smet, Wouter Uten, Hugues Malonne, Pierre Kerkhofs, Jo De Cock, Veerle Matheeussen, Bruno Verhasselt, Laurent Gillet, Gautier Detry, Bertrand Bearzatto, Jonathan Degosserie, Coralie Henin, Gregor Pairoux, Piet Maes, Marc Van Ranst, Katrien Lagrou, Elisabeth Dequeker, Emmanuel Andre, and COVID-19 Genomics Belgium Consortium. 2024. “Nationwide Quality Assurance of High-Throughput Diagnostic Molecular Testing during the SARS-CoV-2 Pandemic : Role of the Belgian National Reference Centre.” VIROLOGY JOURNAL 21 (1). doi:10.1186/s12985-024-02308-y.
Vancouver
1.
Janssen R, Cuypers L, Laenen L, Keyaerts E, Beuselinck K, Janssenswillen S, et al. Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre. VIROLOGY JOURNAL. 2024;21(1).
IEEE
[1]
R. Janssen et al., “Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre,” VIROLOGY JOURNAL, vol. 21, no. 1, 2024.
@article{01HQ8GB8V5GJGY18P6EM4G7EC7,
  abstract     = {{Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre (NRC) for respiratory pathogens, to be the first Belgian laboratory to develop and implement laboratory developed diagnostic assays for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and later to assess the quality of commercial kits. To meet the growing demand for decentralised testing, both clinical laboratories and government-supported high-throughput platforms were gradually deployed across Belgium. Consequently, the role of the NRC transitioned from a specialised testing laboratory to strengthening capacity and coordinating quality assurance. Here, we outline the measures taken by the NRC, the national public health institute Sciensano and the executing clinical laboratories to ensure effective quality management of molecular testing throughout the initial two years of the pandemic (March 2020 to March 2022).}},
  articleno    = {{40}},
  author       = {{Janssen, Reile and Cuypers, Lize and Laenen, Lies and  Keyaerts, Els and  Beuselinck, Kurt and  Janssenswillen, Sunita and  Slechten, Bram and  Bode, Jannes and  Wollants, Elke and  Van Laethem, Kristel and  Rector, Annabel and  Bloemen, Mandy and  Sijmons, Anke and  de Schaetzen, Nathalie and  Capron, Arnaud and  Van Baelen, Kurt and  Pascal, Thierry and  Vermeiren, Celine and  Bureau, Fabrice and Vandesompele, Jo and De Smet, Pieter and  Uten, Wouter and  Malonne, Hugues and  Kerkhofs, Pierre and  De Cock, Jo and  Matheeussen, Veerle and Verhasselt, Bruno and  Gillet, Laurent and  Detry, Gautier and  Bearzatto, Bertrand and  Degosserie, Jonathan and  Henin, Coralie and  Pairoux, Gregor and  Maes, Piet and  Van Ranst, Marc and  Lagrou, Katrien and  Dequeker, Elisabeth and  Andre, Emmanuel and Genomics Belgium Consortium, COVID-19}},
  issn         = {{1743-422X}},
  journal      = {{VIROLOGY JOURNAL}},
  keywords     = {{National reference centre,High-throughput testing,Quality assurance,elgium,COVID-19,SARS-CoV-2}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{17}},
  title        = {{Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic : role of the Belgian National Reference Centre}},
  url          = {{http://doi.org/10.1186/s12985-024-02308-y}},
  volume       = {{21}},
  year         = {{2024}},
}
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