Untangling the gordian knot : the intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects
- Author
- Bart Geens, Stijn Goossens, Jia Li (UGent) , Yves Van de Peer (UGent) and Jozef Vanden Broeck
- Organization
- Project
- Abstract
- Hormones control developmental and physiological processes, often by regulating the expression of multiple genes simultaneously or sequentially. Crosstalk between hormones and epigenetics is pivotal to dynamically coordinate this process. Hormonal signals can guide the addition and removal of epigenetic marks, steering gene expression. Conversely, DNA methylation, histone modifications and non-coding RNAs can modulate regional chromatin structure and accessibility and regulate the expression of numerous (hormone-related) genes. Here, we provide a review of the interplay between the classical insect hormones, ecdysteroids and juvenile hormones, and epigenetics. We summarize the mode-of-action and roles of these hormones in post-embryonic development, and provide a general overview of epigenetic mechanisms. We then highlight recent advances on the interactions between these hormonal pathways and epigenetics, and their involvement in development. Furthermore, we give an overview of several 'omics techniques employed in the field. Finally, we discuss which questions remain unanswered and possible avenues for future research.
- Keywords
- Endocrinology, Molecular Biology, Biochemistry, DNA methylation, Ecdysteroids, Histone modification, Insect development, Juvenile Hormone, Non -coding RNA, DNA METHYLTRANSFERASE FAMILY, RED FLOUR BEETLE, EXTRA-SEX-COMBS, DROSOPHILA-MELANOGASTER, ECDYSONE RECEPTOR, MESSENGER-RNA, GENE-EXPRESSION, TRANSPOSABLE ELEMENTS, EVOLUTIONARY INSIGHTS, DEPENDENT DEVELOPMENT
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HPYXCG2CPC5PAV3773YF1VYF
- MLA
- Geens, Bart, et al. “Untangling the Gordian Knot : The Intertwining Interactions between Developmental Hormone Signaling and Epigenetic Mechanisms in Insects.” MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 585, 2024, doi:10.1016/j.mce.2024.112178.
- APA
- Geens, B., Goossens, S., Li, J., Van de Peer, Y., & Vanden Broeck, J. (2024). Untangling the gordian knot : the intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 585. https://doi.org/10.1016/j.mce.2024.112178
- Chicago author-date
- Geens, Bart, Stijn Goossens, Jia Li, Yves Van de Peer, and Jozef Vanden Broeck. 2024. “Untangling the Gordian Knot : The Intertwining Interactions between Developmental Hormone Signaling and Epigenetic Mechanisms in Insects.” MOLECULAR AND CELLULAR ENDOCRINOLOGY 585. https://doi.org/10.1016/j.mce.2024.112178.
- Chicago author-date (all authors)
- Geens, Bart, Stijn Goossens, Jia Li, Yves Van de Peer, and Jozef Vanden Broeck. 2024. “Untangling the Gordian Knot : The Intertwining Interactions between Developmental Hormone Signaling and Epigenetic Mechanisms in Insects.” MOLECULAR AND CELLULAR ENDOCRINOLOGY 585. doi:10.1016/j.mce.2024.112178.
- Vancouver
- 1.Geens B, Goossens S, Li J, Van de Peer Y, Vanden Broeck J. Untangling the gordian knot : the intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2024;585.
- IEEE
- [1]B. Geens, S. Goossens, J. Li, Y. Van de Peer, and J. Vanden Broeck, “Untangling the gordian knot : the intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects,” MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 585, 2024.
@article{01HPYXCG2CPC5PAV3773YF1VYF,
abstract = {{Hormones control developmental and physiological processes, often by regulating the expression of multiple genes simultaneously or sequentially. Crosstalk between hormones and epigenetics is pivotal to dynamically coordinate this process. Hormonal signals can guide the addition and removal of epigenetic marks, steering gene expression. Conversely, DNA methylation, histone modifications and non-coding RNAs can modulate regional chromatin structure and accessibility and regulate the expression of numerous (hormone-related) genes. Here, we provide a review of the interplay between the classical insect hormones, ecdysteroids and juvenile hormones, and epigenetics. We summarize the mode-of-action and roles of these hormones in post-embryonic development, and provide a general overview of epigenetic mechanisms. We then highlight recent advances on the interactions between these hormonal pathways and epigenetics, and their involvement in development. Furthermore, we give an overview of several 'omics techniques employed in the field. Finally, we discuss which questions remain unanswered and possible avenues for future research.}},
articleno = {{112178}},
author = {{Geens, Bart and Goossens, Stijn and Li, Jia and Van de Peer, Yves and Vanden Broeck, Jozef}},
issn = {{0303-7207}},
journal = {{MOLECULAR AND CELLULAR ENDOCRINOLOGY}},
keywords = {{Endocrinology,Molecular Biology,Biochemistry,DNA methylation,Ecdysteroids,Histone modification,Insect development,Juvenile Hormone,Non -coding RNA,DNA METHYLTRANSFERASE FAMILY,RED FLOUR BEETLE,EXTRA-SEX-COMBS,DROSOPHILA-MELANOGASTER,ECDYSONE RECEPTOR,MESSENGER-RNA,GENE-EXPRESSION,TRANSPOSABLE ELEMENTS,EVOLUTIONARY INSIGHTS,DEPENDENT DEVELOPMENT}},
language = {{eng}},
pages = {{18}},
title = {{Untangling the gordian knot : the intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects}},
url = {{http://doi.org/10.1016/j.mce.2024.112178}},
volume = {{585}},
year = {{2024}},
}
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