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Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model

T. Odenthal, B. Smeets, Paul Van Liedekerke (UGent) , E. Tijskens, H. Van Oosterwyck and H. Ramon
(2013) PLOS COMPUTATIONAL BIOLOGY. 9(10).
Author
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Abstract
Adhesion governs to a large extent the mechanical interaction between a cell and its microenvironment. As initial cell spreading is purely adhesion driven, understanding this phenomenon leads to profound insight in both cell adhesion and cell-substrate interaction. It has been found that across a wide variety of cell types, initial spreading behavior universally follows the same power laws. The simplest cell type providing this scaling of the radius of the spreading area with time are modified red blood cells (RBCs), whose elastic responses are well characterized. Using a mechanistic description of the contact interaction between a cell and its substrate in combination with a deformable RBC model, we are now able to investigate in detail the mechanisms behind this universal power law. The presented model suggests that the initial slope of the spreading curve with time results from a purely geometrical effect facilitated mainly by dissipation upon contact. Later on, the spreading rate decreases due to increasing tension and dissipation in the cell's cortex as the cell spreads more and more. To reproduce this observed initial spreading, no irreversible deformations are required. Since the model created in this effort is extensible to more complex cell types and can cope with arbitrarily shaped, smooth mechanical microenvironments of the cells, it can be useful for a wide range of investigations where forces at the cell boundary play a decisive role.

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MLA
Odenthal, T., et al. “Analysis of Initial Cell Spreading Using Mechanistic Contact Formulations for a Deformable Cell Model.” PLOS COMPUTATIONAL BIOLOGY, vol. 9, no. 10, 2013, doi:10.1371/journal.pcbi.1003267.
APA
Odenthal, T., Smeets, B., Van Liedekerke, P., Tijskens, E., Van Oosterwyck, H., & Ramon, H. (2013). Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model. PLOS COMPUTATIONAL BIOLOGY, 9(10). https://doi.org/10.1371/journal.pcbi.1003267
Chicago author-date
Odenthal, T., B. Smeets, Paul Van Liedekerke, E. Tijskens, H. Van Oosterwyck, and H. Ramon. 2013. “Analysis of Initial Cell Spreading Using Mechanistic Contact Formulations for a Deformable Cell Model.” PLOS COMPUTATIONAL BIOLOGY 9 (10). https://doi.org/10.1371/journal.pcbi.1003267.
Chicago author-date (all authors)
Odenthal, T., B. Smeets, Paul Van Liedekerke, E. Tijskens, H. Van Oosterwyck, and H. Ramon. 2013. “Analysis of Initial Cell Spreading Using Mechanistic Contact Formulations for a Deformable Cell Model.” PLOS COMPUTATIONAL BIOLOGY 9 (10). doi:10.1371/journal.pcbi.1003267.
Vancouver
1.
Odenthal T, Smeets B, Van Liedekerke P, Tijskens E, Van Oosterwyck H, Ramon H. Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model. PLOS COMPUTATIONAL BIOLOGY. 2013;9(10).
IEEE
[1]
T. Odenthal, B. Smeets, P. Van Liedekerke, E. Tijskens, H. Van Oosterwyck, and H. Ramon, “Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model,” PLOS COMPUTATIONAL BIOLOGY, vol. 9, no. 10, 2013.
@article{01HPPXSXTY63A542FGT113E0Z1,
  abstract     = {{Adhesion governs to a large extent the mechanical interaction between a cell and its microenvironment. As initial cell spreading is purely adhesion driven, understanding this phenomenon leads to profound insight in both cell adhesion and cell-substrate interaction. It has been found that across a wide variety of cell types, initial spreading behavior universally follows the same power laws. The simplest cell type providing this scaling of the radius of the spreading area with time are modified red blood cells (RBCs), whose elastic responses are well characterized. Using a mechanistic description of the contact interaction between a cell and its substrate in combination with a deformable RBC model, we are now able to investigate in detail the mechanisms behind this universal power law. The presented model suggests that the initial slope of the spreading curve with time results from a purely geometrical effect facilitated mainly by dissipation upon contact. Later on, the spreading rate decreases due to increasing tension and dissipation in the cell's cortex as the cell spreads more and more. To reproduce this observed initial spreading, no irreversible deformations are required. Since the model created in this effort is extensible to more complex cell types and can cope with arbitrarily shaped, smooth mechanical microenvironments of the cells, it can be useful for a wide range of investigations where forces at the cell boundary play a decisive role.}},
  articleno    = {{e1003267}},
  author       = {{Odenthal, T. and Smeets, B. and Van Liedekerke, Paul and Tijskens, E. and Van Oosterwyck, H. and Ramon, H.}},
  issn         = {{1553-7358}},
  journal      = {{PLOS COMPUTATIONAL BIOLOGY}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{14}},
  title        = {{Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model}},
  url          = {{http://doi.org/10.1371/journal.pcbi.1003267}},
  volume       = {{9}},
  year         = {{2013}},
}
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