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History of exposure to copper influences transgenerational gene expression responses in Daphnia magna

Guilherme Jeremias, Ana-Belén Muñiz-González, Fernando José Mendes Gonçalves, José-Luis Martínez-Guitarte, Jana Asselman (UGent) and Joana Luísa Pereira
(2024) EPIGENETICS. 19(1).
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Abstract
The establishment of transgenerational effects following chemical exposure is a powerful phenomenon, capable of modulating ecosystem health beyond exposure periods. This study assessed the transgenerational effects occurring due to copper exposure in the invertebrate D. magna at the transcriptional level, while evaluating the role of exposure history on such responses. Thus, daphnids acclimated for several generations in a copper vs. clean medium were then exposed for one generation (F0) to this metal, and monitored for the following non-exposed generations (F1, F2 and F3). Organisms differing in exposure histories showed remarkably different transcriptional profiles at the F0, with na & iuml;ve organisms being more profoundly affected. These trends were confirmed for F3 treatments, which presented different transcriptional patterns for genes involved in detoxification, oxidative stress, DNA damage repair, circadian clock functioning and epigenetic regulation. Furthermore, regardless of exposure history, a great number of histone modifier genes were always found transcriptionally altered, thus suggesting the involvement of histone modifications in the response of Daphnia to metal exposure. Lastly, remarkably distinct transgenerational transcriptional responses were found between na & iuml;ve and non-na & iuml;ve organisms, thereby highlighting the influence of exposure history on gene expression and confirming the capacity of metals to determine transgenerational transcriptional effects across non-exposed generations.
Keywords
Metals, invertebrates, molecular responses, RT-PCR, transgenerational effects, epigenetics, EPIGENETIC INHERITANCE, CIRCADIAN CLOCK, DNA-REPAIR, STRESS, PROFILES, TOXICITY, ACCLIMATION, VALIDATION, MICRORNAS, CADMIUM

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Citation

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MLA
Jeremias, Guilherme, et al. “History of Exposure to Copper Influences Transgenerational Gene Expression Responses in Daphnia Magna.” EPIGENETICS, vol. 19, no. 1, 2024, doi:10.1080/15592294.2023.2296275.
APA
Jeremias, G., Muñiz-González, A.-B., Mendes Gonçalves, F. J., Martínez-Guitarte, J.-L., Asselman, J., & Luísa Pereira, J. (2024). History of exposure to copper influences transgenerational gene expression responses in Daphnia magna. EPIGENETICS, 19(1). https://doi.org/10.1080/15592294.2023.2296275
Chicago author-date
Jeremias, Guilherme, Ana-Belén Muñiz-González, Fernando José Mendes Gonçalves, José-Luis Martínez-Guitarte, Jana Asselman, and Joana Luísa Pereira. 2024. “History of Exposure to Copper Influences Transgenerational Gene Expression Responses in Daphnia Magna.” EPIGENETICS 19 (1). https://doi.org/10.1080/15592294.2023.2296275.
Chicago author-date (all authors)
Jeremias, Guilherme, Ana-Belén Muñiz-González, Fernando José Mendes Gonçalves, José-Luis Martínez-Guitarte, Jana Asselman, and Joana Luísa Pereira. 2024. “History of Exposure to Copper Influences Transgenerational Gene Expression Responses in Daphnia Magna.” EPIGENETICS 19 (1). doi:10.1080/15592294.2023.2296275.
Vancouver
1.
Jeremias G, Muñiz-González A-B, Mendes Gonçalves FJ, Martínez-Guitarte J-L, Asselman J, Luísa Pereira J. History of exposure to copper influences transgenerational gene expression responses in Daphnia magna. EPIGENETICS. 2024;19(1).
IEEE
[1]
G. Jeremias, A.-B. Muñiz-González, F. J. Mendes Gonçalves, J.-L. Martínez-Guitarte, J. Asselman, and J. Luísa Pereira, “History of exposure to copper influences transgenerational gene expression responses in Daphnia magna,” EPIGENETICS, vol. 19, no. 1, 2024.
@article{01HP6PYVEQ12PM2302G96V6C0S,
  abstract     = {{The establishment of transgenerational effects following chemical exposure is a powerful phenomenon, capable of modulating ecosystem health beyond exposure periods. This study assessed the transgenerational effects occurring due to copper exposure in the invertebrate D. magna at the transcriptional level, while evaluating the role of exposure history on such responses. Thus, daphnids acclimated for several generations in a copper vs. clean medium were then exposed for one generation (F0) to this metal, and monitored for the following non-exposed generations (F1, F2 and F3). Organisms differing in exposure histories showed remarkably different transcriptional profiles at the F0, with na & iuml;ve organisms being more profoundly affected. These trends were confirmed for F3 treatments, which presented different transcriptional patterns for genes involved in detoxification, oxidative stress, DNA damage repair, circadian clock functioning and epigenetic regulation. Furthermore, regardless of exposure history, a great number of histone modifier genes were always found transcriptionally altered, thus suggesting the involvement of histone modifications in the response of Daphnia to metal exposure. Lastly, remarkably distinct transgenerational transcriptional responses were found between na & iuml;ve and non-na & iuml;ve organisms, thereby highlighting the influence of exposure history on gene expression and confirming the capacity of metals to determine transgenerational transcriptional effects across non-exposed generations.}},
  articleno    = {{2296275}},
  author       = {{Jeremias, Guilherme and Muñiz-González, Ana-Belén and Mendes Gonçalves, Fernando José and Martínez-Guitarte, José-Luis and Asselman, Jana and Luísa Pereira, Joana}},
  issn         = {{1559-2294}},
  journal      = {{EPIGENETICS}},
  keywords     = {{Metals,invertebrates,molecular responses,RT-PCR,transgenerational effects,epigenetics,EPIGENETIC INHERITANCE,CIRCADIAN CLOCK,DNA-REPAIR,STRESS,PROFILES,TOXICITY,ACCLIMATION,VALIDATION,MICRORNAS,CADMIUM}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15}},
  title        = {{History of exposure to copper influences transgenerational gene expression responses in Daphnia magna}},
  url          = {{http://doi.org/10.1080/15592294.2023.2296275}},
  volume       = {{19}},
  year         = {{2024}},
}
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