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Chestnut wood tannins in broiler diets : pharmacokinetics, serum levels during rearing, and intestinal absorption pattern of gallic acid

Kobe Buyse (UGent) , Evelyne Delezie, Luc Goethals, Noémie Van Noten, Christof Van Poucke, Mathias Devreese (UGent) , Gunther Antonissen (UGent) , Geert Janssens (UGent) and Marta Ribeiro Alves Lourenço (UGent)
(2024) JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 72(5). p.2648-2656
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Abstract
Studies on the bioavailability, serum levels, and absorption of hydrolyzable tannin compounds are lacking. In this study, we performed a pharmacokinetic trial, measured the serum levels of compounds in broilers that were reared with different feed added or not with tannins, and tested the digestibility of tannins throughout the intestinal tract. Only gallic acid and 4-O-methyl gallic acid were found in the serum. Moreover, gallic acid showed a 41.8% absolute oral bioavailability and a 72.3% relative bioavailability of gallic acid from chestnut extract compared to the standard. The rapid metabolization caused alternating serum levels during the day and night. These patterns were not affected by the feed type or the previous addition of tannins in the feed. The absorption and metabolization in the intestines occurred gradually throughout the intestinal tract. The latter was true for gallic acid as well as ellagic acid, which was not found in the serum. We can conclude that components from chestnut tannins are absorbed throughout all components of the intestinal tract and are eliminated quickly with little interaction from the feed and previous addition of tannins. Moreover, ellagic acid seems to be absorbed but would remain accumulated in the intestinal tissue or be metabolized by the microbiome.
Keywords
General Agricultural and Biological Sciences, General Chemistry, broiler chicken, chestnut tannins, gallic acid, pharmacokinetics, absorption, ELLAGIC ACID, METABOLIC-FATE, HUMAN PLASMA, BIOAVAILABILITY, PERFORMANCE, ELLAGITANNINS, POLYPHENOLS, EXTRACT, BINDING, PROTEIN

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MLA
Buyse, Kobe, et al. “Chestnut Wood Tannins in Broiler Diets : Pharmacokinetics, Serum Levels during Rearing, and Intestinal Absorption Pattern of Gallic Acid.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 72, no. 5, American Chemical Society (ACS), 2024, pp. 2648–56, doi:10.1021/acs.jafc.3c09881.
APA
Buyse, K., Delezie, E., Goethals, L., Van Noten, N., Van Poucke, C., Devreese, M., … Ribeiro Alves Lourenço, M. (2024). Chestnut wood tannins in broiler diets : pharmacokinetics, serum levels during rearing, and intestinal absorption pattern of gallic acid. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72(5), 2648–2656. https://doi.org/10.1021/acs.jafc.3c09881
Chicago author-date
Buyse, Kobe, Evelyne Delezie, Luc Goethals, Noémie Van Noten, Christof Van Poucke, Mathias Devreese, Gunther Antonissen, Geert Janssens, and Marta Ribeiro Alves Lourenço. 2024. “Chestnut Wood Tannins in Broiler Diets : Pharmacokinetics, Serum Levels during Rearing, and Intestinal Absorption Pattern of Gallic Acid.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72 (5): 2648–56. https://doi.org/10.1021/acs.jafc.3c09881.
Chicago author-date (all authors)
Buyse, Kobe, Evelyne Delezie, Luc Goethals, Noémie Van Noten, Christof Van Poucke, Mathias Devreese, Gunther Antonissen, Geert Janssens, and Marta Ribeiro Alves Lourenço. 2024. “Chestnut Wood Tannins in Broiler Diets : Pharmacokinetics, Serum Levels during Rearing, and Intestinal Absorption Pattern of Gallic Acid.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72 (5): 2648–2656. doi:10.1021/acs.jafc.3c09881.
Vancouver
1.
Buyse K, Delezie E, Goethals L, Van Noten N, Van Poucke C, Devreese M, et al. Chestnut wood tannins in broiler diets : pharmacokinetics, serum levels during rearing, and intestinal absorption pattern of gallic acid. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2024;72(5):2648–56.
IEEE
[1]
K. Buyse et al., “Chestnut wood tannins in broiler diets : pharmacokinetics, serum levels during rearing, and intestinal absorption pattern of gallic acid,” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 72, no. 5, pp. 2648–2656, 2024.
@article{01HP6MBZKMHECWY5PCW34F2RS0,
  abstract     = {{Studies on the bioavailability, serum levels, and absorption of hydrolyzable tannin compounds are lacking. In this study, we performed a pharmacokinetic trial, measured the serum levels of compounds in broilers that were reared with different feed added or not with tannins, and tested the digestibility of tannins throughout the intestinal tract. Only gallic acid and 4-O-methyl gallic acid were found in the serum. Moreover, gallic acid showed a 41.8% absolute oral bioavailability and a 72.3% relative bioavailability of gallic acid from chestnut extract compared to the standard. The rapid metabolization caused alternating serum levels during the day and night. These patterns were not affected by the feed type or the previous addition of tannins in the feed. The absorption and metabolization in the intestines occurred gradually throughout the intestinal tract. The latter was true for gallic acid as well as ellagic acid, which was not found in the serum. We can conclude that components from chestnut tannins are absorbed throughout all components of the intestinal tract and are eliminated quickly with little interaction from the feed and previous addition of tannins. Moreover, ellagic acid seems to be absorbed but would remain accumulated in the intestinal tissue or be metabolized by the microbiome.}},
  author       = {{Buyse, Kobe and Delezie, Evelyne and Goethals, Luc and Van Noten, Noémie and Van Poucke, Christof and Devreese, Mathias and Antonissen, Gunther and Janssens, Geert and Ribeiro Alves Lourenço, Marta}},
  issn         = {{0021-8561}},
  journal      = {{JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY}},
  keywords     = {{General Agricultural and Biological Sciences,General Chemistry,broiler chicken,chestnut tannins,gallic acid,pharmacokinetics,absorption,ELLAGIC ACID,METABOLIC-FATE,HUMAN PLASMA,BIOAVAILABILITY,PERFORMANCE,ELLAGITANNINS,POLYPHENOLS,EXTRACT,BINDING,PROTEIN}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{2648--2656}},
  publisher    = {{American Chemical Society (ACS)}},
  title        = {{Chestnut wood tannins in broiler diets : pharmacokinetics, serum levels during rearing, and intestinal absorption pattern of gallic acid}},
  url          = {{http://doi.org/10.1021/acs.jafc.3c09881}},
  volume       = {{72}},
  year         = {{2024}},
}
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