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Small intestine vs. colon ecology and physiology : why it matters in probiotic administration

Benjamin Anderschou Holbech Jensen, Marc Heyndrickx (UGent) , Daisy Jonkers, Alan Mackie, Sam Millet, Malwina Naghibi, Simone Isling Paerregaard, Bruno Pot, Delphine Saulnier, Christian Sina, et al.
(2023) CELL REPORTS MEDICINE. 4(9).
Author
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Abstract
Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.
Keywords
INFLAMMATORY-BOWEL-DISEASE, GUT MICROBIOME, DEFENSIN DEFICIENCY, BARRIER DYSFUNCTION, CROHNS-DISEASE, CELLS, SUSCEPTIBILITY, COLITIS, DRIVEN, MODEL

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MLA
Jensen, Benjamin Anderschou Holbech, et al. “Small Intestine vs. Colon Ecology and Physiology : Why It Matters in Probiotic Administration.” CELL REPORTS MEDICINE, vol. 4, no. 9, Elsevier, 2023, doi:10.1016/j.xcrm.2023.101190.
APA
Jensen, B. A. H., Heyndrickx, M., Jonkers, D., Mackie, A., Millet, S., Naghibi, M., … Ouwehand, A. C. (2023). Small intestine vs. colon ecology and physiology : why it matters in probiotic administration. CELL REPORTS MEDICINE, 4(9). https://doi.org/10.1016/j.xcrm.2023.101190
Chicago author-date
Jensen, Benjamin Anderschou Holbech, Marc Heyndrickx, Daisy Jonkers, Alan Mackie, Sam Millet, Malwina Naghibi, Simone Isling Paerregaard, et al. 2023. “Small Intestine vs. Colon Ecology and Physiology : Why It Matters in Probiotic Administration.” CELL REPORTS MEDICINE 4 (9). https://doi.org/10.1016/j.xcrm.2023.101190.
Chicago author-date (all authors)
Jensen, Benjamin Anderschou Holbech, Marc Heyndrickx, Daisy Jonkers, Alan Mackie, Sam Millet, Malwina Naghibi, Simone Isling Paerregaard, Bruno Pot, Delphine Saulnier, Christian Sina, Luc Gerardus Willibrordus Sterkman, Pieter Van den Abbeele, Naomi Vita Venlet, Erwin G. Zoetendal, and Arthur Constantijn Ouwehand. 2023. “Small Intestine vs. Colon Ecology and Physiology : Why It Matters in Probiotic Administration.” CELL REPORTS MEDICINE 4 (9). doi:10.1016/j.xcrm.2023.101190.
Vancouver
1.
Jensen BAH, Heyndrickx M, Jonkers D, Mackie A, Millet S, Naghibi M, et al. Small intestine vs. colon ecology and physiology : why it matters in probiotic administration. CELL REPORTS MEDICINE. 2023;4(9).
IEEE
[1]
B. A. H. Jensen et al., “Small intestine vs. colon ecology and physiology : why it matters in probiotic administration,” CELL REPORTS MEDICINE, vol. 4, no. 9, 2023.
@article{01HNWDP5VCTD8REPR1CJ656X66,
  abstract     = {{Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.}},
  articleno    = {{101190}},
  author       = {{Jensen, Benjamin Anderschou Holbech and Heyndrickx, Marc and Jonkers, Daisy and  Mackie, Alan and  Millet, Sam and  Naghibi, Malwina and  Paerregaard, Simone Isling and  Pot, Bruno and  Saulnier, Delphine and  Sina, Christian and  Sterkman, Luc Gerardus Willibrordus and  Van den Abbeele, Pieter and  Venlet, Naomi Vita and  Zoetendal, Erwin G. and  Ouwehand, Arthur Constantijn}},
  issn         = {{2666-3791}},
  journal      = {{CELL REPORTS MEDICINE}},
  keywords     = {{INFLAMMATORY-BOWEL-DISEASE,GUT MICROBIOME,DEFENSIN DEFICIENCY,BARRIER DYSFUNCTION,CROHNS-DISEASE,CELLS,SUSCEPTIBILITY,COLITIS,DRIVEN,MODEL}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{16}},
  publisher    = {{Elsevier}},
  title        = {{Small intestine vs. colon ecology and physiology : why it matters in probiotic administration}},
  url          = {{http://doi.org/10.1016/j.xcrm.2023.101190}},
  volume       = {{4}},
  year         = {{2023}},
}
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