@article{01HNFG70S7T9S4TDXQJD6MZ9PB,
  abstract     = {{Objectives: To compare clinical characteristics, including the frequency of cutaneous, extramuscular manifestations and malignancy, between adults with anti-synthetase syndrome (ASyS) and DM. Methods: Using data regarding adults from the MYONET registry, a cohort of DM patients with anti-Mi2/-TIF1 gamma/-NXP2/-SAE/-MDA5 autoantibodies, and a cohort of ASyS patients with anti-tRNA synthetase autoantibodies (anti-Jo1/-PL7/-PL12/-OJ/-EJ/-Zo/-KS) were identified. Patients with DM sine dermatitis or with discordant dual autoantibody specificities were excluded. Sub-cohorts of patients with ASyS with or without skin involvement were defined based on presence of DM-type rashes (heliotrope rash, Gottron's papules/sign, violaceous rash, shawl sign, V-sign, erythroderma, and/or periorbital rash). Results: In total 1054 patients were included (DM, n = 405; ASyS, n = 649). In the ASyS cohort, 31% (n = 203) had DM-type skin involvement (ASyS-DMskin). A higher frequency of extramuscular manifestations, including Mechanic's hands, Raynaud's phenomenon, arthritis, interstitial lung disease and cardiac involvement differentiated ASyS-DMskin from DM (all P < 0.001), whereas higher frequency of any of four DM-type rashes-heliotrope rash (n = 248, 61% vs n = 90, 44%), violaceous rash (n = 166, 41% vs n = 57, 9%), V-sign (n = 124, 31% vs n = 28, 4%), and shawl sign (n = 133, 33% vs n = 18, 3%)-differentiated DM from ASyS-DMskin (all P < 0.005). Cancer-associated myositis (CAM) was more frequent in DM (n = 67, 17%) compared with ASyS (n = 21, 3%) and ASyS-DMskin (n = 7, 3%) cohorts (both P < 0.001). Conclusion: DM-type rashes are frequent in patients with ASyS; however, distinct clinical manifestations differentiate these patients from classical DM. Skin involvement in ASyS does not necessitate increased malignancy surveillance. These findings will inform future ASyS classification criteria and patient management.}},
  author       = {{Hum, Ryan Malcolm and Lilleker, James B and Lamb, Janine A and Oldroyd, Alexander G S and Wang, Guochun and Wedderburn, Lucy R and Diederichsen, Louise P and Schmidt, Jens and Danieli, Maria Giovanna and Oakley, Paula and Griger, Zoltan and Nguyen Thi Phuong, Thuy and Kodishala, Chanakya and Vazquez-Del Mercado, Monica and Andersson, Helena and De Paepe, Boel and De Bleecker, Jan and Maurer, Britta and McCann, Liza and Pipitone, Nicolo and McHugh, Neil and New, Robert Paul and Ollier, William E and Krogh, Niels Steen and Vencovsky, Jiri and Lundberg, Ingrid E and Chinoy, Hector and D’Hose, Sophie and Lu, Xin and Tian, Xiaolan and Mann, Heřman and Kryštůfková, Olga and Pleštilová, Lenka and Klein, Martin and Barochová, Tereza and Kubínová, Kateřina and Gelardi, Chiara and Paladini, Alberto and Piga, Mario Andrea and Jara, Luis J and Saavedra, Miguel A and Cruz-Reyes, Claudia V and Vera-Lastra, Olga and Andrade-Ortega, Lilia and Medrano-Ramírez, Gabriel and Satoh, Minoru and Salazar-Páramo, Mario and Chavarría-Ávila, Efrain and Aguilar-Vazquez, Andrea and Anda, Jesus-Aureliano Robles-de and Petri, Marcelo H and Molberg, Øyvind and Dastmalchi, Maryam and Notarnicola, Antonella and Gheorghe, Karina and Rönnelid, Johan and Liden, Maria and Hanna, Balsam and Jalal, Awat and Hellström, Helena and Martineus, Jehns Christian and Lan, Nguyen Thi Ngoc and Padyukov, Leonid and New, Paul and Platt, Hazel and Rothwell, Simon and Ahmed, Yasmeen and Armstrong, Raymond and Bernstein, Robert and Black, Carol and Bowman, Simon and Bruce, Ian and Butler, Robin and Carty, John and Chattopadhyay, Chandra and Chelliah, Easwaradhas and Clarke, Fiona and Dawes, Peter and Denton, Christopher and Devlin, Joseph and Edwards, Christopher and Emery, Paul and Fordham, John and Fraser, Alexander and Gaston, Hill and Gordon, Patrick and Griffiths, Bridget and Gunawardena, Harsha and Hall, Frances and Hanna, Michael and Harrison, Beverley and Hay, Elaine and Hilton-Jones, David and Horden, Lesley and Isaacs, John and Isenberg, David and Jones, Adrian and Kamath, Sanjeet and Kennedy, Thomas and Kitas, George and Klimiuk, Peter and Knights, Sally and Lambert, John and Lanyon, Peter and Laxminarayan, Ramasharan and Lecky, Bryan and Luqmani, Raashid and Machado, Pedro and Marks, Jeffrey and Martin, Michael and McGonagle, Dennis and McKenna, Francis and McLaren, John and McMahon, Michael and McRorie, Euan and Merry, Peter and Miles, Sarah and Miller, James and Nicholls, Anne and Nixon, Jennifer and Ong, Voon and Over, Katherine and Packham, John and Plant, Michael and Pountain, Gillian and Pullar, Thomas and Roberts, Mark and Sanders, Paul and Scott, David and Scott, David and Shadforth, Michael and Sheeran, Thomas and Srinivasan, Arul and Swinson, David and Teh, Lee-Suan and Webley, Michael and Williams, Brian and Winer, Jonathan and MYONET Registry, [missing]}},
  issn         = {{1462-0324}},
  journal      = {{RHEUMATOLOGY}},
  keywords     = {{Pharmacology (medical),Rheumatology,Extramuscular,MYONET,Epidemiology,Malignancy,Skin,Rashes,Cutaneous,Dermatomyositis,Anti-synthetase syndrome}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{2093--2100}},
  title        = {{Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry}},
  url          = {{http://doi.org/10.1093/rheumatology/kead481}},
  volume       = {{63}},
  year         = {{2024}},
}

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