A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis
- Author
- Nataliia Konstantinova (UGent) , Eliana Mor, Eline Verhelst (UGent) , Jonah Nolf (UGent) , Kenzo Vereecken (UGent) , Feng Wang (UGent) , Daniël Van Damme (UGent) , Bert De Rybel (UGent) and Matous Glanc (UGent)
- Organization
- Project
-
- BOF-ZAP-ambt in ontwikkelingsbiologie van planten
- Unraveling the molecular and cellular basis of vascular tissue formation
- Identification and characterization molecular targets of novel small molecules involved in controlling plant cell division orientation.
- ZAP-ambt in het kader van ERC-project T-REX
- Abstract
- Transcriptional networks are crucial to integrate various internal and external signals into optimal responses during plant growth and development. Primary root vasculature patterning and proliferation are controlled by a network centred around the basic Helix-Loop-Helix transcription factor complex formed by TARGET OF MONOPTEROS 5 (TMO5) and LONESOME HIGHWAY (LHW), which control cell proliferation and orientation by modulating cytokinin response and other downstream factors. Despite recent progress, many aspects of the TMO5/LHW pathway are not fully understood. In particular, the upstream regulators of TMO5/LHW activity remain unknown. Here, using a forward genetic approach to identify new factors of the TMO5/LHW pathway, we discovered a novel function of the MYB-type transcription factor MYB12. MYB12 physically interacts with TMO5 and dampens the TMO5/LHW-mediated induction of direct target gene expression as well as the periclinal/radial cell divisions. The expression of MYB12 is activated by the cytokinin response, downstream of TMO5/LHW, resulting in a novel MYB12-mediated negative feedback loop that restricts TMO5/LHW activity to ensure optimal cell proliferation rates during root vascular development.
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HN05CQFRRERCD4CY38WY74F3
- MLA
- Konstantinova, Nataliia, et al. A Precise Balance of TETRASPANIN1/TORNADO2 Activity Is Required for Vascular Proliferation and Ground Tissue Patterning in Arabidopsis. Cold Spring Harbor Laboratory, 2023, doi:10.1101/2023.10.18.562921.
- APA
- Konstantinova, N., Mor, E., Verhelst, E., Nolf, J., Vereecken, K., Wang, F., … Glanc, M. (2023). A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis. https://doi.org/10.1101/2023.10.18.562921
- Chicago author-date
- Konstantinova, Nataliia, Eliana Mor, Eline Verhelst, Jonah Nolf, Kenzo Vereecken, Feng Wang, Daniël Van Damme, Bert De Rybel, and Matous Glanc. 2023. “A Precise Balance of TETRASPANIN1/TORNADO2 Activity Is Required for Vascular Proliferation and Ground Tissue Patterning in Arabidopsis.” Cold Spring Harbor Laboratory. https://doi.org/10.1101/2023.10.18.562921.
- Chicago author-date (all authors)
- Konstantinova, Nataliia, Eliana Mor, Eline Verhelst, Jonah Nolf, Kenzo Vereecken, Feng Wang, Daniël Van Damme, Bert De Rybel, and Matous Glanc. 2023. “A Precise Balance of TETRASPANIN1/TORNADO2 Activity Is Required for Vascular Proliferation and Ground Tissue Patterning in Arabidopsis.” Cold Spring Harbor Laboratory. doi:10.1101/2023.10.18.562921.
- Vancouver
- 1.Konstantinova N, Mor E, Verhelst E, Nolf J, Vereecken K, Wang F, et al. A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis. Cold Spring Harbor Laboratory; 2023.
- IEEE
- [1]N. Konstantinova et al., “A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis.” Cold Spring Harbor Laboratory, 2023.
@misc{01HN05CQFRRERCD4CY38WY74F3,
abstract = {{Transcriptional networks are crucial to integrate various internal and external signals into optimal responses during plant growth and development. Primary root vasculature patterning and proliferation are controlled by a network centred around the basic Helix-Loop-Helix transcription factor complex formed by TARGET OF MONOPTEROS 5 (TMO5) and LONESOME HIGHWAY (LHW), which control cell proliferation and orientation by modulating cytokinin response and other downstream factors. Despite recent progress, many aspects of the TMO5/LHW pathway are not fully understood. In particular, the upstream regulators of TMO5/LHW activity remain unknown. Here, using a forward genetic approach to identify new factors of the TMO5/LHW pathway, we discovered a novel function of the MYB-type transcription factor MYB12. MYB12 physically interacts with TMO5 and dampens the TMO5/LHW-mediated induction of direct target gene expression as well as the periclinal/radial cell divisions. The expression of MYB12 is activated by the cytokinin response, downstream of TMO5/LHW, resulting in a novel MYB12-mediated negative feedback loop that restricts TMO5/LHW activity to ensure optimal cell proliferation rates during root vascular development.}},
articleno = {{2023.10.18.562921}},
author = {{Konstantinova, Nataliia and Mor, Eliana and Verhelst, Eline and Nolf, Jonah and Vereecken, Kenzo and Wang, Feng and Van Damme, Daniël and De Rybel, Bert and Glanc, Matous}},
language = {{und}},
publisher = {{Cold Spring Harbor Laboratory}},
title = {{A precise balance of TETRASPANIN1/TORNADO2 activity is required for vascular proliferation and ground tissue patterning in Arabidopsis}},
url = {{http://doi.org/10.1101/2023.10.18.562921}},
year = {{2023}},
}
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