From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals
- Author
- Eline Goossens (UGent) , Loren Deblock (UGent) , Lisa Caboor (UGent) , Dietger Van den Eynden, Iván Josipovic (UGent) , Pablo Reyes Isaacura (UGent) , Elizaveta Maksimova, Matthias Van Impe (UGent) , Anne Bonnin, Patrick Segers (UGent) , Pieter Cornillie (UGent) , Matthieu Boone (UGent) , Isabel Van Driessche (UGent) , Ward De Spiegelaere (UGent) , Jonathan De Roo (UGent) , Patrick Sips (UGent) and Klaartje De Buysser (UGent)
- Organization
- Project
-
- Design of hafnium oxide nanocrystals as computed tomography contrast agent for damage detection in high-end composites.
- Synthesis and surface chemistry of doped hafnium oxide nanocrystals for dual-modality bio-imaging
- Fluid-structure-growth modeling of the ageing aorta in humans: biomechanical and hemodynamic consequences of elastin degradation
- Using advanced fluid dynamics modelling for cardiovascular phenotyping of zebrafish models
- An integrated translational platform to improve the management and outcome of rare heritable connective tissue disease
- Generic materials study towards high quality advanced medical, food and engineering 3D structures
- UGCT – Ghent University Centre for X-ray Tomography
- Cofinancing core facility - Centre for X-ray Tomography – UGCT
- Abstract
- Vascular corrosion casting is a method used to visualize the three dimensional (3D) anatomy and branching pattern of blood vessels. A polymer resin is injected in the vascular system and, after curing, the surrounding tissue is removed. The latter often deforms or even fractures the fragile cast. Here, a method is proposed that does not require corrosion, and is based on in situ micro computed tomography (micro-CT) scans. To overcome the lack of CT contrast between the polymer cast and the animals' surrounding soft tissue, hafnium oxide nanocrystals (HfO2 NCs) are introduced as CT contrast agents into the resin. The NCs dramatically improve the overall CT contrast of the cast and allow for straightforward segmentation in the CT scans. Careful design of the NC surface chemistry ensures the colloidal stability of the NCs in the casting resin. Using only 5 m% of HfO2 NCs, high-quality cardiovascular casts of both zebrafish and mice can be automatically segmented using CT imaging software. This allows to differentiate even mu$\umu$m-scale details without having to alter the current resin injection methods. This new method of virtual dissection by visualizing casts in situ using contrast-enhanced CT imaging greatly expands the application potential of the technique. Vascular corrosion casting suffers from deformations and fractures during corrosion. A method based on in situ micro-computed tomography (micro-CT) scans is introduced, using hafnium oxide nanocrystals as CT contrast agents to overcome the lack of contrast between the polymer cast and the surrounding soft tissue. The drastic contrast enhancement enables automatic segmentation, effectively removing the corrosion from corrosion casting.image
- Keywords
- General Materials Science, General Chemistry, nanocrystals, hafnium oxide, corrosion casting, contrast, computed tomography
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01HMVC16J410QDGP9FZ8FFHXF7
- MLA
- Goossens, Eline, et al. “From Corrosion Casting to Virtual Dissection : Contrast‐enhanced Vascular Imaging Using Hafnium Oxide Nanocrystals.” SMALL METHODS, vol. 8, no. 10, 2024, doi:10.1002/smtd.202301499.
- APA
- Goossens, E., Deblock, L., Caboor, L., Van den Eynden, D., Josipovic, I., Reyes Isaacura, P., … De Buysser, K. (2024). From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals. SMALL METHODS, 8(10). https://doi.org/10.1002/smtd.202301499
- Chicago author-date
- Goossens, Eline, Loren Deblock, Lisa Caboor, Dietger Van den Eynden, Iván Josipovic, Pablo Reyes Isaacura, Elizaveta Maksimova, et al. 2024. “From Corrosion Casting to Virtual Dissection : Contrast‐enhanced Vascular Imaging Using Hafnium Oxide Nanocrystals.” SMALL METHODS 8 (10). https://doi.org/10.1002/smtd.202301499.
- Chicago author-date (all authors)
- Goossens, Eline, Loren Deblock, Lisa Caboor, Dietger Van den Eynden, Iván Josipovic, Pablo Reyes Isaacura, Elizaveta Maksimova, Matthias Van Impe, Anne Bonnin, Patrick Segers, Pieter Cornillie, Matthieu Boone, Isabel Van Driessche, Ward De Spiegelaere, Jonathan De Roo, Patrick Sips, and Klaartje De Buysser. 2024. “From Corrosion Casting to Virtual Dissection : Contrast‐enhanced Vascular Imaging Using Hafnium Oxide Nanocrystals.” SMALL METHODS 8 (10). doi:10.1002/smtd.202301499.
- Vancouver
- 1.Goossens E, Deblock L, Caboor L, Van den Eynden D, Josipovic I, Reyes Isaacura P, et al. From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals. SMALL METHODS. 2024;8(10).
- IEEE
- [1]E. Goossens et al., “From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals,” SMALL METHODS, vol. 8, no. 10, 2024.
@article{01HMVC16J410QDGP9FZ8FFHXF7,
abstract = {{Vascular corrosion casting is a method used to visualize the three dimensional (3D) anatomy and branching pattern of blood vessels. A polymer resin is injected in the vascular system and, after curing, the surrounding tissue is removed. The latter often deforms or even fractures the fragile cast. Here, a method is proposed that does not require corrosion, and is based on in situ micro computed tomography (micro-CT) scans. To overcome the lack of CT contrast between the polymer cast and the animals' surrounding soft tissue, hafnium oxide nanocrystals (HfO2 NCs) are introduced as CT contrast agents into the resin. The NCs dramatically improve the overall CT contrast of the cast and allow for straightforward segmentation in the CT scans. Careful design of the NC surface chemistry ensures the colloidal stability of the NCs in the casting resin. Using only 5 m% of HfO2 NCs, high-quality cardiovascular casts of both zebrafish and mice can be automatically segmented using CT imaging software. This allows to differentiate even mu$\umu$m-scale details without having to alter the current resin injection methods. This new method of virtual dissection by visualizing casts in situ using contrast-enhanced CT imaging greatly expands the application potential of the technique.
Vascular corrosion casting suffers from deformations and fractures during corrosion. A method based on in situ micro-computed tomography (micro-CT) scans is introduced, using hafnium oxide nanocrystals as CT contrast agents to overcome the lack of contrast between the polymer cast and the surrounding soft tissue. The drastic contrast enhancement enables automatic segmentation, effectively removing the corrosion from corrosion casting.image}},
articleno = {{2301499}},
author = {{Goossens, Eline and Deblock, Loren and Caboor, Lisa and Van den Eynden, Dietger and Josipovic, Iván and Reyes Isaacura, Pablo and Maksimova, Elizaveta and Van Impe, Matthias and Bonnin, Anne and Segers, Patrick and Cornillie, Pieter and Boone, Matthieu and Van Driessche, Isabel and De Spiegelaere, Ward and De Roo, Jonathan and Sips, Patrick and De Buysser, Klaartje}},
issn = {{2366-9608}},
journal = {{SMALL METHODS}},
keywords = {{General Materials Science,General Chemistry,nanocrystals,hafnium oxide,corrosion casting,contrast,computed tomography}},
language = {{eng}},
number = {{10}},
pages = {{15}},
title = {{From corrosion casting to virtual dissection : contrast‐enhanced vascular imaging using hafnium oxide nanocrystals}},
url = {{http://doi.org/10.1002/smtd.202301499}},
volume = {{8}},
year = {{2024}},
}
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