@phdthesis{01HMBT1GVZAH1BY2DS3WA2V2MZ,
  abstract     = {{This PhD primarily focused on determining an optimized dose of ML endectocides (via PK/PD studies) for indigenous Ethiopian zebu cattle for its use as new complementary malaria vector control tool. In sub-Saharan Africa (SSA), malaria elimination with current vector-control strategies is hindered by residual transmission. The residual transmission is mainly linked with the vector’s behavioral adaptation (outdoor biting and/or resting behavior) and insecticide resistance along with the abundance of zoophagic and anthropophagic vectors. Outdoor biting Anopheles mosquitoes tend to seek blood meals more from livestock mainly cattle as alternative blood meals source when humans are not accessible. Consequently, livestock blood meals contribute largely to vectors abundance and increased densities, even though animals are not a parasite reservoir for malaria disease. Hence, a complementary tool targeted to livestock, mainly cattle, is essential for the control of outdoor feeding zoophagic vectors to divert their blood meal source from toxic blood from animals. With this regard, mass treatment of cattle with an endectocide is a new approach. Animal species and breed difference have an impact on the pharmacokinetics(PK) of endectocides, thereby affecting or altering their optimal effects. In indigenous zebu cattle, PK data is scarce for macrocyclic lactone endectocides (ivermectin, doramectin and moxidectin). Therefore, For malaria vector control, an optimized ML endectocide dose was determined after the bioanalysis, PK-PD assessment of the ML endectocides in indigenous Ethiopian zebu cattle as described in this thesis. The effects of the sub-lethal concentrations on P. vivax parasite were also assessed.}},
  author       = {{Iticha, Gemechu Zeleke}},
  language     = {{eng}},
  pages        = {{VIII, 158}},
  publisher    = {{Ghent University. Faculty of Veterinary Medicine}},
  school       = {{Ghent University}},
  title        = {{Endectocide treatment of cattle as complementary tool for malaria control in Sub-Saharan Africa}},
  year         = {{2024}},
}